A dressing for wound healing is provided, wherein the dressing includes a hydrogen sulfide (H.sub.2S) donor compound. The dressing facilitates the delivery of H.sub.2S to a wound site in a controlled manner, which results in an improved wound healing process by stimulating angiogenesis and anti-inflammatory action. In some embodiments, the wound dressing can include an electrospun nanofiber dressing, a sponge dressing, or a hydrogel dressing.

Systems, devices, methods, and compositions are described for providing an actively controllable implant configured to, for example, monitor, treat, or prevent microbial growth or adherence to the implant.

A hemostatic textile comprising glass fibers circular knit with bamboo-sourced rayon fibers in a tubular fashion. The knitted textile is scoured and dried to shrink the bamboo-sourced rayon relative to the glass fibers and to orient the glass fibers exteriorly of the bamboo-sourced rayon fibers such that when the hemostatic textile is administered to a wound, the glass fibers are the first to come in contact with any wound fluid, for example blood. This orientation aids in the activation of the hemostatic response which leads to faster clot times and improved overall wound-healing. A method of manufacturing and utilizing the hemostatic textile is also provided.

Disclosed are compositions that comprise an organic electrochemical mediator and a gasotransmitter salt which converts into a gasotransmitter via electron transfer. Also disclosed are bandages and wound dressings comprising the subject gasotransmitters, and methods of making a gasotransmitters, comprising exposing the compositions to a voltage sufficient to reduce the water soluble organic mediator. Further disclosed are methods of treating a variety of trauma and disease states by applying a therapeutically effective amount of at least one gasotransmitter thereto, and methods of generating an effective dose of the gasotransmitter generated from electrolytic reaction involving the gasotransmitter-generating compositions.

An absorbent article selected from a sanitary napkin, an incontinence pad and a pantyliner, comprising a topsheet layer, a backsheet layer, a fastening adhesive applied on the backsheet garment facing surface. The adhesive comprises one or more thermoplastic elastomers. The article comprises a fragrance or odor control composition comprising one more esters, having a log P value of 2.9 or higher and a Kovats Retention Index of 1450 or higher, at least 90% of which are in encapsulated or complexed form.

A composition and method for chlorine dioxide production through reaction-diffusion chemistry that facilitates the in situ generation of chlorine dioxide, wherein a dry solid composition of hydroxymethanesulfinic acid monosodium salt dihydrate (abbreviated HMS) and a chlorine dioxide precursor are activated via the addition or absorption of water to produce chlorine dioxide. The dry solid chemical composition comprises dry, safe, transportable reagents that integrate with polymeric materials such as packaging and superabsorbent and stimuli-responsive hydrogel polymers to combine with water to produce chlorine dioxide.

An implantable device for providing a therapeutic agent includes a container configured to contain multiple cells capable of producing the therapeutic agent within an interior region of the container and a substance capable of reacting to generate oxygen for the multiple cells within the interior region of the container. The container defines first pores defined by an interior wall portion of the container and second pores defined by an exterior wall portion of the container. The first pores have a first average size that (i) allows passage of the therapeutic agent through the first pores and (ii) prevents passage of immune cells through the first pores. The second pores have a second average size that is larger than the first average size, and the second pores are sized to promote vascularization along the exterior wall portion.

Post-operative infection in joint prostheses is a problem due to adverse consequences such as surgical debridement or implant removal. Embodiments create a coating that can be powered to release microbicidal agents to both ensure the prevention of infections, and avoid the development of antibiotic resistance. Silver ions have been well established for antimicrobial characteristics, and thus make an advantageous implant coating. Reverse electrolysis allows the ions to be released for a sustained period of time, and then collected back onto to the implant to avoid silver poisoning. A wireless reverse electrolysis system releases a sufficient amount of silver ions to break down biofilm surrounding a joint implant. By applying a modulated current waveform that has a net negative value to a conducting copper strip, the mirror current induced on the silver coating surface has a net positive flow, allowing ions to be released into surrounding tissue. Using this method, an average silver concentration of 32 ppb is created in surrounding medium after 12 hours, sufficient to eradicate bacteria directly around the silver. The ability to wirelessly induce electrolysis of silver ions to kill a significant quantity of bacteria can be used in surgical procedures to avoid post-operative infection in joint prostheses.

Oxygen-charged (or oxygen-rich) implantable medical devices for and methods of local delivery of oxygen via outgassing is disclosed. The presently disclosed oxygen-charged implantable medical devices are, for example, polymeric implants that are functionalized to locally deliver oxygen from the implant surface for prolonged periods of time, thus increasing rates of healing and reducing rates of infection as compared with conventional medical implant devices.

A system that includes a biocompatible polymeric matrix and a separately-stored fluid for improving delivery of a therapeutic gas to an area beneath a surface of intact skin or a wound site is provided. The system can preserve the therapeutic gas in the matrix such that its concentration remains generally constant until the system is ready for use, at which time the separately-stored fluid can be added or exposed to the matrix to activate the matrix and thus increase the permeability of the biocompatible polymeric matrix to the therapeutic gas, thus facilitating delivery of the therapeutic gas for the purpose of the treatment of wounds and intact skin is provided. A method of using the, as well as a deactivated matrix and its method of use for delivery of a therapeutic gas, are also provided.