Plasma-enriched hydroxyapatite-based fillers and methods of filling bone gaps in oral surgery, orthopedic procedures, and cosmetic surgery are disclosed. The fillers contain a substance comprising an anticoagulant antidote, a substance comprising hydroxyapatite, and blood or plasma. The blood may be either autologous or allogeneic. The fillers have a dough-like consistency and can be manipulated easily by a surgeon.

The invention provides a constituent that is used with a novel method for preventing and/or treating skin wounds and ensures stable delivery of low-concentration hydrogen sulfide to a wound site. The skin wound-preventing and/or treating constituent includes a sustained hydrogen sulfide releasing agent that is preferably a layered double hydroxide having HS and/or Sk2- between layers where k is a positive integer.

Provided herein is a tag comprising an imaging sphere suspended within a matrix. In some embodiments, the matrix comprises a polymer. In some embodiments, the matrix comprises an adhesive polymer. In some embodiments, the matrix comprises a shelf-stable polymer. In some embodiments, the matrix comprises an epoxy. In some embodiments, the adhesive polymer comprises cyanoacrylate. In some embodiments, the imaging sphere comprises a cavity loaded with an imaging agent surrounded by a shell. In some embodiments, the imaging agent exhibits echogenic properties. Further provided is a method for preparing an imaging sphere comprising: depositing organic or inorganic material onto a bead surface to form a sphere with a solid core; removing the solid core by solvent extraction or calcination to form a hollow sphere; and loading the hollow sphere with an imaging agent.

Disclosed are anticoagulant and decoagulant methods, compositions and devices comprising calcium carbonate, particularly, comprising aragonite.

In an example, nitrogen is implanted into a bone and heated so as to be incorporated into the bone.

Glass-based particles of a biocompatible material which comprises 40 to about 80 wt % borate (B.sub.2O.sub.3) intermixed into a carrier which is an ointment, cream, or surgical glue.

Systems, devices, methods, and compositions are described for providing an actively controllable implant configured to, for example, monitor, treat, or prevent microbial growth or adherence to the implant.

The present disclosure specifically relates to a liquid dressing for promoting wound healing. The liquid dressing comprises components of, in percentage by weight: 1% to 2% of monomeric silicic acid and 98% to 99% of distilled water. The liquid dressing also comprises aloe, vitamin C, fish oil, and curcumin. The components comprise, in percentage by weight: 1% to 2% of monomeric silicic acid, 3% to 5% of aloe, 5% to 7% of vitamin C, 1% to 3% of fish oil, 1% to 2% of curcumin, and the balance being the distilled water. The liquid dressing for promoting wound healing in the present disclosure has a great promotion effect on wound healing, particularly in accelerating healing of refractory wounds caused by hyperglycemia. Moreover, the liquid dressing for promoting wound healing in the present disclosure has a certain auxiliary effect on other refractory wounds that do not heal for a long time.

Methods for improving the antibacterial and/or bone-forming characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant may comprise a composite of a silicon nitride ceramic powder dispersed within a poly-ether-ether-ketone (PEEK) or a poly-ether-ketone-ketone (PEKK) substrate material. In some implementations, the biomedical implant may be 3D printed.

The present disclosure is related to inorganic, biocompatible material compositions for bioactivatable devices, devices, and products comprising transition metal chalcogenides, such as molybdenum sulfides, that can be converted in vivo from a non-bioactive state to a bioactive state upon exposure to physiological conditions, wherein the bioactivated transition metal chalcogenide derivatives, such as molybdenum sulfide derivatives, exhibit copper-chelating activities. Various methods for the application of these compositions for enhancing biocompatibility and reducing or modulating copper-dependent biological reactions are provided.