A wound dressing system comprising a wrap and a frangible ampoule is provided. The wrap is configured to contact/surround a wound site and includes an oxygen catalyst. The ampoule includes an oxygen precursor. The catalyst and precursor are configured to form oxygen when combined. A wound dressing system including a container is also provided that includes a powder, wrap, and frangible ampoule. The powder is disposed within the container, which is configured to allow the powder to be dispersed onto a wound site when activated. The wrap, which may include an oxygen catalyst, is also disposed in the container and is configured to contact/surround the wound site. The ampoule, also disposed in the container, includes a liquid containing an oxygen precursor. The liquid is configured to contact the wrap when the container is activated. Further, the catalyst and precursor are configured to form oxygen when combined.

Compositions, methods, and applications for ablative-chemical infused hydrogels are described. The hydrogels are biodegradable and can be formed in situ. The hydrogels are effective for delivering tissue ablative chemicals to target sites. The hydrogel delivered tissue ablative chemicals can be particularly effective for performing intrauterine ablation, even when fibroids are present, or for scarring fallopian tubes for birth control via minimally invasive procedures. The hydrogels can also be particularly effective at avoiding contact of tissue ablative chemicals with off-target tissues. The hydrogels can be installed using various delivery vehicles, including injections and catheters. The hydrogels can be designed to be retained in the target site for a period of hours to days, so that targeted tissue ablation can proceed in an ambulatory patient. Methods for transcervical installation of in situ formed hydrogels into the uterus or one or more fallopian tubes are described.

An odor control layer for personal care products has a composition that has a PEG or PEG copolymer composition applied thereto. The layer can be placed in a personal care product, such as a diaper, training pant, absorbent under pant, adult incontinence product, or feminine hygiene product. Additional odor control layers may include silver nanoparticles and activated carbon compositions. In an alternative form, a single odor control layer includes the PEG composition and the activated carbon and/or silver nanoparticle compositions. A cleansing composition with PEG and possibly active carbon and silver nanoparticles may be combined with the personal care product to form a kit.

An implantable medical product and method of use for substantially reducing or eliminating harsh biological responses associated with conventionally implanted medical devices, including inflammation, infection and thrombogenesis, when implanted in in a body of a warm blooded mammal. The bioremodelable pouch structure is configured and sized to receive, encase and retain an electrical medical device therein and to allow such device to be inserted into the internal region or cavity of the pouch structure; with the pouch structure formed from either: (a) first and second sheets, or (b) a single sheet having first and second sheet portions. After receiving the electrical device, the edges around the opening are closed by suturing or stapling. The medical device encased by the bioremodelable pouch structure effectively improves biological functions by promoting tissue regeneration, modulated healing of adjacent tissue or growth of new tissue when implanted in the body of the mammal.

A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.

Provided is a nanofiber composite membrane for guided bone regeneration, which includes: spinning a spinning solution by an electrospinning method to produce nanofibers; accumulating the nanofibers, to prepare a certain thickness of a nanofiber web; and drying and thermally calendering the nanofiber web to sterilize the nanofiber web, wherein the spinning solution contains a biocompatible plasticizer to maintain physical properties, flexibility and elasticity of the membrane, by suppressing an increase in brittleness in a sterilization treatment.

Various stent assemblies for placement in a body lumen that includes a support element comprising metal struts constructed to be positioned in a body lumen, and a knitted layer or cover disposed over an interior, an exterior, or both, of the support element and along an entire length thereof, wherein the knitted layer or cover comprises a single polymer fiber or metal wire having a diameter of at least 40 nanometers to 30 microns, wherein the support element and knitted cover together have apertures sized 100 microns to 300 microns in diameter, or alternatively from 200 microns to 1500 microns, to block larger debris when the stent assembly is properly placed in a body lumen. Methods of stenting a body lumen by applying the stent assembly to a patient in need of treatment and expanding the stent assembly in situ are disclosed.

The present invention relates to a process of treating an implant, comprising a step of treating the surface of the implant with at least one phosphonic acid compound or a pharmaceutically acceptable salt, ester or amide thereof under sonication at a temperature of about 50? C. to about 90? C. This process is highly advantageous in that it allows the formation of a monolayer of the phosphonic acid compound on the implant surface, having a particularly dense surface coverage which, in turn, results in an improved implant biocompatibility and improved osseointegration. The invention further relates to a surface-treated implant obtainable by this process and, in particular, it provides an implant having a surface made of a metal, a metal alloy or a ceramic, wherein a phosphonic acid compound or a pharmaceutically acceptable salt, ester or amide thereof is bound to the surface of the implant and forms a monolayer having an implant surface coverage, in terms of the ratio of the phosphorus content to the metal content as determined by X-ray photoelectron spectroscopy (XPS), of at least 70% of a reference maximum surface coverage.

A sheet structure formed from an extracellular matrix (ECM) composition that includes acellular ECM derived from small intestine submucosa (SIS) tissue, gentamicin and vancomycin. The sheet structure is configured to modulate inflammation of damaged biological tissue and induce cell and tissue proliferation, bioremodeling of the damaged biological tissue, and regeneration of new tissue and tissue structures with site-specific structural and functional properties, when the tissue structure is delivered to the damaged biological tissue.

A coating formed of a substituted polycaprolactone and method of making and using the same are disclosed.