A method of forming an implant for the repair of defects in bone. the method comprises the steps of: electrospinning bioactive glass fibres: compressing the electrospun bioactive glass fibres to form a compressed body: heating the compressed body to bond the fibres to form a shaped body: heat treating the shaped body to form a heat-treated shaped body. There is also disclosed an implant for use in repairing critical or sub critical bone defects.

A medical tube including a copper-based compound, which is relatively inexpensive, is easy to process, is not toxic, and has excellent antibacterial activity, comprises: a tube comprising a polymer resin and having a predetermined shape and diameter; and a copper-based compound coated on the surface of the tube or dispersed in the polymer resin of the tube, wherein the compound has a chemical structure of Cu.sub.xM.sub.y, wherein M is any one selected from groups 15 to 17 of the periodic table, and x/y is 0.5-1.5.

A dental implant and a method for manufacturing same which assure early stability and fixation power of an implant by suppressing early osteolysis after an implant procedure, and allowing better bone coherence of the implant surface during an osteogenic period by controlling the speed of bone remodeling.

The invention is to articles of extracellular matrix. The articles comprise one or more sheets of mammalian extracellular matrix laminated together. A single sheet can be folded over and laminated on 3 sides. Two or more sheets can be laminated to each other at their edges. The sheets can further encase a composition comprising a cell or cells, such as for example, a stem cell. A single sheet can be folded over to encase a composition, or rolled to encase a composition with lamination at either end of the roll, for example. The invention also includes methods of using these articles to regenerate tissue at tissue defects, or heal wounds in damaged tissue.

A tissue prosthesis comprising an extracellular matrix (ECM) composition, the ECM composition comprising decellularized ECM derived from mesothelial tissue and an exogenously added basic fibroblast growth factor (bFGF).

Implantable matrices and methods are provided. The matrices are configured to fit at or near a target tissue site, the matrices comprise biodegradable materials and ligands bound to the matrices and are configured to bind receptors and allow influx of cells into the implantable matrices, wherein the ratio of ligands to receptors is from about 1.5 to about 0.5.

A sheet structure formed from an extracellular matrix (ECM) composition that includes acellular ECM derived from small intestine submucosa (SIS) tissue, gentamicin and vancomycin. The sheet structure is configured to modulate inflammation of damaged biological tissue and induce cell and tissue proliferation, bioremodeling of the damaged biological tissue, and regeneration of new tissue and tissue structures with site-specific structural and functional properties, when the tissue structure is delivered to the damaged biological tissue.

A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.

Dermal filler hydrogel compositions, methods of making them, and methods of using them to treat soft tissue conditions, such as wrinkles, are provided. The compositions contain a crosslinked hyaluronic acid-based polymer and one or more additional ingredients, and are stable to sterilization by heat and/or pressure treatment. The additional ingredients include vasoconstrictive agents, antioxidant agents, such as a ascorbic acid agents, and/or anesthetic agents.

This invention relates to reducing the risk of arrhythmias as a result of an acute cardiovascular disorder or injury such as a myocardial infarction by using mitochondrial-targeted antioxidants to improve cardiac function.