A biomaterial including a resorbable porous matrix formed from a material including collagen, and exhibiting an inner volume and an outer surface. Advantageously, the biomaterial includes at least one type of living biological cells of a tissue, disposed in the inner volume and alternatively or complementarily on the surface of the porous matrix. The biomaterial forms a tissue substitute being close to a native tissue, in particular in terms of biological structure present in the tissue, and physiological functions.

Compositions and methods related to powdered hemostats that crosslink during and/or after application to a bleeding site are described. The compositions may comprise a first component comprising a polyalkylene oxide-based polymer functionalized with electrophilic reactive groups, and a second component that comprises a protein such as albumin and an optional crosslinking initiator—which may be a base or basic salt such as sodium bicarbonate. The compositions may in certain applications act as hemostats when applied in dry powder form to a bleeding wound, whereupon the first component and the second component of the composition crosslink to form a hydrogel.

A method of production of a tissue sealing patch is disclosed. The method comprises applying a vacuum to a heated work surface; applying a solution of a biocompatible polyurethane polymer to the work surface and spreading it over the work surface with a polymer blade; evaporating the solvent; heating the work surface above the softening temperature of the polymer; spreading powdered tissue sealant material over the polymer film; incorporating the tissue sealant material to a depth of 20-60 μm in the film by pressing on a release sheet placed over the powder and polymer film; removing the release sheet from the adhesive patch material; releasing the vacuum; cooling said work surface; and removing the adhesive patch material from said work surface. The biocompatible polymer preferably comprises PEG-caprolactone-lactic acid units connected by urethane linkages, the PEG having a molecular weight of 3000-3500 amu, and a CL:LA:PEG ratio of 34:2:1.

The present invention relates to a composition for hemostasis which contains collagen, stabilizer, and thrombin, and a container including the same. The present invention is applicable to a bleeding patient requiring emergency treatment with a simple method of use. There is no toxicity and no problem of blood infection. A biodegradation rate is fast. In this regard, the present invention achieves an excellent hemostatic effect. Therefore, the composition for hemostasis is useful as a hemostat.

The present disclosure relates to a gastrointestinal delivery device of a chitosan dressing, where the delivery device is capable of stop bleeding, in particular in connection with TURP procedures. The delivery device may be used in all gastrointestinal bleeding applications and can be used with a biocompatible, foldable, thin profile, chitosan dressing. Various aspects of the device and its uses are provided herein.

Provided is a local hemostasis material, which exerts little influence on the human body, is inexpensive, and exerts a good hemostatic. The local hemostasis material comprises a base material having a first major surface and a layer including cationized cellulose on the first major surface, wherein the layer including cationized cellulose has a thickness of no less than 6.7 .Math.m.

The invention relates to antimicrobial and/or antiviral fabric compositions comprising ascorbic acid, citric acid, sodium hypophosphite, or a mixture thereof. The ascorbic acid may be covalently attached to at least one cellulosic portion of the fabric composition. The invention also relates to methods for preparing such fabric compositions.

The present invention is directed to a hemostatic patch comprising a porous substrate and at least a pair of co-reactive polymer reagents comprising at least one nucleophilic polyalkylene oxide based component and at least one electrophilic polyalkylene oxide-based on the porous substrate in a molar ratio of about 0.2 to about 0.9:1 of primary nucleophilic groups in excess to available electrophilic groups. The present invention is also directed to processes for the manufacture and use of such hemostatic patches.

The present technology provides a composition comprising a mixture of a source of calcium ions, alginate conjugated to an acrylate monomer (ALG-A), carboxymethylcellulose conjugated to an acrylate monomer (CMC-A) and water, wherein the mixture is a shear-thinning gel. The compositions may further include a polythiol agent. Such compositions are injectable due to their shear-thinning properties, yet stay in place, undergo in situ crosslinking, and provide safe, simple and efficacious endovascular embolization. Methods of making and using such compositions are also provided.

A dispensing system includes a hollow tube having an outer wall with an air vent formed in the outer wall. A valve including a flexible flap is disposed inside the tube. The flexible flap, normally biased into a retracted position, is moveable between an extended position for sealing the air vent and the retracted position for unsealing the air vent. A syringe connector interconnects a syringe with the proximal end of the hollow tube and defines a fluid flow path. A flowable viscous fluid is disposed within the syringe. When a syringe plunger is depressed, the flowable viscous fluid is expelled from the syringe and forced through the fluid flow path and into the proximal end of the hollow tube. When the flowable viscous fluid engages the flexible flap, the flexible flap is forced to move into a position that seals the air vent.