Disclosed herein are manufacturing/casting processes for the preparation of a foam.

The present disclosure relates to a process for the processing of perfluoropolymer materials, and to the use of the resultant products in different potential applications, such as in the medical device field. The process can include, for example, the steps of: (i) dissolving one or more uncured perfluoropolymer materials in a solvent containing one or more liquid perfluorinated solvent(s) to form a solution; (ii) optionally adding one or more porogens and/or one or more functional additives to the solution formed in (i) to form a mixture; (iii) applying the resultant solution or mixture formed in steps (i) and (ii) to a substrate to form one or more partial or continuous deposited layers on the substrate; (iv) curing the perfluoropolymer within the deposited layer to form a perfluoroelastomeric product; and (v) optionally removing the porogen from the perfluoroelastomeric product.

In some embodiments, the present invention provides methods for making resorbable ear tubes including the steps of providing a silk fibroin solution, and forming a silk ear tube from the silk fibroin solution, wherein the silk ear tube is less than 2 mm in length and has an outer diameter of less than 1.5 mm, and wherein the silk ear tube is resorbable. In some embodiments, the present invention also provides methods for treating otitis media including the step of introducing a silk ear tube into the ear canal of a subject, wherein the silk ear tube is less than 2 mm in length and has an outer diameter of less than 1.5 mm, and wherein the silk ear tube is resorbed by the subject.

This invention relates to production method comprising processes of slip casting and freeze drying, which is a hybrid system, for developing hydroxyapatite-containing bio-ceramic developed by combined utilization of medical and engineering sciences in order to use on bone diseases, wherein it discloses a new hybrid system comprising process steps of preparing a first suspension containing powder ceramic, solvent and dispersant mixture by slip casting method, molding the first suspension mixture and allowing it to dry from outside to inside, pouring excessive (residual) slip (first suspension) out of the mold when it reaches to desired thickness, removing the material shaped to form compact part (6) of the bone cortical layer from the mold, preparation of the second suspension mixture comprising powder ceramic, solvent, dispersant and binder for the formation of the trabecular part (5) by freeze drying, cooling the second suspension until the liquid (1) is frozen so as to form trabecular part (5), obtaining the solid (2) by removing the free water in the substance to be dried in the first drying phase, removing the relative water to obtain vapor (3) in the second drying phase.

The present disclosure provides magnetically templated tissue scaffolds, methods of making the magnetically templated tissue scaffolds, and various methods of employing the scaffolds for tissue growth and repair in vitro and in vivo, including peripheral nerve repair.

The present application relates to a method and device for processing tissue. The method and device allow for machining of soft tissue samples to produce uniform shapes (e.g., uniform thicknesses) or reliably produce alterations such as openings or holes in soft tissue products. The method and device can alternatively or additionally be used to process tissue to produce particulates with desired properties.

The present disclosure relates to injectable and expandable compositions, devices, kits and methods for use in an approach for the in-situ foaming of polymers for bone or tissue defects, namely to fill and/or fuse a tissue defect. The present disclosure relates to compositions, devices, kits and methods for use in an approach for the in-situ foaming of polymers for bone or tissue defects, namely for bone tissue defect filling/fusion. The design of extendable and expandable compositions for bone fusion is one of the most challenging fields in the intersection of polymer and biomedical engineering. An aspect of the present disclosure relates to an injectable expandable composition for use in medicine, veterinary or cosmetic, comprising a polycaprolactone particle filler; a polydopamine adhesive bound to said filler; a polymethacrylic acid plasticizer bound to said polydopamine adhesive.

An improved new method of making a multi-component implant comprising a solid hydrogel, a porous hydrogel, and a porous rigid base suitable for implantation into a mammal, to treat, repair or replace defects and/or injury biological tissue as well as the implant made from the improved method. The invention also includes an improved method for making devices, constructs, and materials comprising a hydrogel and a porous rigid material. The invention also includes a mold and kits for performing the methods.

The present disclosure provides information on the methodology used in the fabrication of three-dimensional cellularized tissue constructs from free-standing evacuable 3D printed composites and/or scaffolds embedded in an extracellular matrix mimic generated from biocompatible materials. The purposes of using these composite and/or scaffold materials is to generate complex embedded lumens that allow for complete perfusion of the matrix construct by standard cell culture media, thereby allowing for maintenance of large-scale 3D cell cultures in specific geometric forms. The use of biological extracellular matrix materials is to provide essential biological and mechanical signals needed to regulate the behavior of encapsulated cells. Furthermore, the methodology can be adapted such that the lumens generated are capable of being seeded with various endothelial and epithelial cell types as desired, thereby allowing for mimicry of in vivo vasculature, intestinal tracts, and other lumen-containing constructs. This disclosure provides the methodology for generating the tissue constructs.

Disclosed is a method for making a composite material, which is of particular use in wound treatment. The composite material has a hydrophilic polyurethane foam material with a first polyurethane polymer; a hydrophilic fiber material having a second polymer, wherein said second polymer is not a polyurethane polymer and wherein said fiber material is capable of absorbing and retaining a fluid. The first polymer is covalently bonded to the second polymer.