Described herein are regenerative approaches with tunable cell-cell and cell-matrix interactions to enhance the ability to regenerate multiple zones within a construct with each zone possessing a unique, optimum, level of cell-cell and cell-matrix interaction.

Provided herein is technology relating to lipid compositions containing bioactive fatty acids and particularly, but not exclusively, to compositions and methods related to the production and use of structured lipid compositions containing sciadonic and/or pinoleic acid alone or in combination with other bioactive fatty acids including, but not limited to, eicosapentaenoic acid, docosahexaenoic acid, conjugated linoleic acid, and non-β-oxidizable fatty acid analogues such as tetradecylthioacetic acid.

A hydrogel comprising a colloidal suspension of M.sup.I.sub.XM.sup.II.sub.YP.sub.Z two-dimensional nanocrystals in water, wherein M.sup.I is Na.sup.+ and/or Li.sup.+, M.sup.II is Mg.sup.2+ or a mixture of Mg.sup.2+ with one or more Ni.sup.2+, Zn.sup.2+, Cu.sup.2+, Fe.sup.2+ and/or Mn.sup.2+, P is a mixture of dibasic phosphate ions (HPO.sub.4.sup.2−) and tribasic phosphate ions (PO.sub.4.sup.3−). X ranges from about 0.43 to about 0.63, Y ranges from about 0.10 to about 0.18, Z ranges from about 0.29 to about 0.48, X, Y, Z being mole fractions, is provided.

The present invention relates to the field of biomedical technology, and relates to a composite membrane comprising a decellularized amniotic membrane, a use of the composite membrane, and a method for preparing the composite membrane.

A filament or printing material placed in a syringe for 3D printing comprising polymers, proteins, and/or functional particles and materials is provided. Methods of treating a bone defect in a subject in need thereof comprising using a handheld 3D printer to apply a filament or the printing material placed in a syringe to the bone defect of the subject are also provided. Methods of fixing or gluing natural or synthetic bone grafts using a handheld 3D printer to apply a filament or the printing material placed in a syringe over and around the defect or at the interface of a flap and the bone. Methods of printing a graft cage for retaining bone grafts and/or bone graft substitute in its desired location during healing for treatment of critical-sized segmental defects in long bones are provided.

An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.

The present invention is generally directed to cannabinoid medical carriers that are effective in the treatment of internal wounds, such as brain or spinal cord injury. One embodiment comprises a application device consisting of a dissolvable biological carrier that contains a cannabinoid, which is readily adsorbed in vivo and is capable of conforming to the size and shape of the surface of the contusion site of a neurological trauma. The various elements of the medical carrier can be saturated with cannabidiol or other phytocannabinoids by diffusion under sterile conditions to achieve medicinal concentrations. The carrier can be applied through open or semi-open surgical procedures, or epidural or by subarachnoid/intrathecal delivery.

The present disclosure provides an adhesive composition including a silicone-based adhesive and cellulose nanocrystals dispersed in the silicone-based adhesive. The present disclosure also provides an article including a substrate and a layer of the adhesive composition adhered to the substrate. Further, the present disclosure provides a method of making an adhesive composition. The method comprises mixing cellulose nanocrystals in a silicone-based adhesive to disperse the cellulose nanocrystals. The present disclosure additionally provides a method of making an article including disposing a layer of the adhesive composition on a substrate. The presence of the cellulose nanocrystals advantageously increases the water uptake capacity of the silicone-based adhesive while maintaining acceptable adhesive performance.

Cellulose-reinforced hydrogels may include a cellulose nanofiber network and an interstitial hydrogel portion within interstitial regions of the cellulose nanofiber network, the interstitial hydrogel portion comprising polyvinyl alcohol (PVA), wherein the hydrogel component has a crystallinity of 20% or greater.

A medical device includes a substrate structure with a surface. The surface is laser treated to define at least one protrusion and/or at least one void extending relative to the surface. A coating having antibacterial, antimicrobial and/or drug eluding properties is applied to the substrate structure such that the coating engages within or along a surface portion of one or more of the protrusions and/or voids.