Disclosed is an ostomy device with an adhesive wafer for attachment to a skin surface (S) of a user and a collecting bag (8) or collecting output from a stoma. The collecting bag is connected to the adhesive wafer, and the adhesive wafer has a through-going hole (6) for accommodating the stoma (7) of the user. The adhesive wafer includes a backing layer (3), a first switchable adhesive composition (2), a second absorbent adhesive composition (1), and a release liner, and the second adhesive layer has a central portion with a first thickness and an edge portion with a second thickness, the first thickness being larger than the second thickness.

Methods of preparing a functionalized nanofiber preparing a dispersion of a polymer and a water soluble synthetic construct of the structure F-S-L in admixture in a liquid medium; and then electrospinning the polymer from the liquid medium to provide the functionalized nanofiber. F is the functional moiety, L is a lipid and S is a spacer linking F to L via covalent bonds.

Disclosed is a base plate 1 for an ostomy collection device, comprising a cover layer 2 whereon an adhesive layer 3 is at least partly disposed. Immediately surrounding a through-going hole 6, the base plate has an inner area wherein the cover layer extends beyond the adhesive layer in a radial direction toward the through-going hole, thereby providing an overlap 7 protecting the adhesive material from contact with stomal output.

The invention provides an ostomy bag assembly comprising outer (2) and inner (4) bags secured to one side of an adhesive flange (6); the adhesive flange (6) having means defining an orifice to enable bodily waste from a stomal opening to be received by the inner bag; wherein the adhesive flange is of laminar construction and comprises, in sequence, from a body-contacting surface outwards: (a) a bioadhesive layer (10) for securing the flange to a body surface of a patient about the stomal opening; (b) a first polymeric support layer (8) attached to the bioadhesive layer (a); (c) a heat sealable layer (16) having a heat sealable adhesive surface which releasably bonds the heat sealable layer to the first polymeric support surface; (d) a second polymeric support layer (14) bonded to the heat sealable layer; (e) a weldable polymeric layer (18) to which the inner and outer bags are attached, the weldable polymeric layer being bonded to the second polymeric support layer;
the adhesive flange having an annular channel (20) which surrounds the means defining the orifice and extends through layers (c), (d) and (e) so as to form radially inner (22) and outer (24) attachment zones separated by the annular channel (20), the inner bag (4) being attached to the radially inner attachment zone (22) and outer bag (2) being attached to the radially outer attachment zone (24);
and wherein the inner and outer bags (4),(2), together with attached portions of layers (c), (d) and (e) can each be peeled away from the first polymeric support layer (b).

Also provided by the invention are adhesive flange blanks from which the ostomy bag assemblies can be manufactured, as well as methods for the manufacture of the ostomy bag assemblies and the adhesive flange blanks.

The present disclosure relates to the field of skin friendly silicone adhesive compositions and use of such compositions to secure medical appliances to mammalian body, and to protect and treat peri-skin surface.

Skin compatible curing adhesives for adhering devices or appliances to mammalian body are disclosed. Adhesive compositions to protect per-anal, peri-stomal, peri-wound, and peri-fistula skin are disclosed. The skin compatible curable adhesive includes at least one silylated polymer, silylated macromer, silylated monomer, or a combination thereof; at least one curing catalyst; and at least one crosslinking agent.

The present invention provides a sensitive, accurate, bioactive skin barrier/wafer usable in ostomy systems and wound drainage collectors for identification of pathogens at critical thresholds of presence on peristomal skin at stoma sites and exuding wounds before clinical signs and symptoms of infection present. A method of fabricating a bioactive skin barrier/wafer intended for identification of pathogen presence in ostomy systems is provided, that delivers a rapid response observable alert. The present invention utilizes biomarkers to detect pathogens in real time, where biomarkers are characteristics objectively measured as indicators of health, disease, or a response to an exposure or intervention, including therapeutic interventions.