This document provides methods and materials for performing retinal pigment epithelium transplantation. For example, methods and materials for using fibrin supports for retinal pigment epithelium transplantation are provided.

A lubricious coating for use on an implantable medical device includes a heterochelic component, a homotelechelic polymer and biocompatible initiator. Methods of forming such lubricious coatings are also provided.

Provided herein is a coated coronary stent, comprising: a. stent framework; b. a plurality of layers deposited on said stent framework to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

Disclosed are compositions, methods and processes for fabricating and using a device or other implement including a surface or surfaces having a nanoscale or microscale layer or coating of Si—O—N—P. These coatings and/or layers may be continuous, on the surface or discontinuous (e.g., patterned, grooved), and may be provided on silica surfaces, metal (e.g., titanium), ceramic, and combination/hybrid materials. Methods of producing an implantable device, such as a load-bearing or non-load-bearing device, such as a bone or other structural implant device (load-bearing), are also presented. Craniofacial, osteogenic and disordered bone regeneration (osteoporosis) uses and applications of devices that include at least one surface that is treated to include a nanoscale or microscale layer or coating of Si—O—N—P are also provided. Methods of using the treated and/or coated devices to enhance enhanced vascularization and healing at a treated surface of a device in vivo, is also presented.

A process for coating parylene onto a metal surface, such as a medical device, that has been textured by a series of laser pulses. The laser pulses can be overlapping or rastered. The textured portion of the metal surface and parylene coating can form a strong mechanical interlock. The bond created by using the laser texturing process can result in a cohesive failure of the parylene and not an adhesive failure of the bonding.

The disclosure relates to a coating composition comprising a polymerizable compound of formula [1], wherein G is a residue of a hydrophobic hydroxy-functional oligomer, n is 1-10, each R1 independently is a residue of a C.sub.6-C.sub.20 aliphatic, cycloaliphatic, or aromatic hydrocarbon compound, and Z is a moiety having a polymerizable group; Formula [1] a hydrophilic polymer; a photo-initiator; optionally one or more further components, and a solvent. The polymerizable compound of formula [1] is typically present in an amount of 2.0-30 mass % based on total dry mass of the composition. Such coating composition can be made into a well-adhering single-layer hydrophilic coating on a surface of polymer substrates without providing a primer layer or chemically modifying the surface of the substrate. Upon wetting, the coating shows excellent lubricity and durability. In further aspects, the disclosure provides a method of applying a hydrophilic and optionally lubricious coating to an article; and an article like a medical device having on at least part of its surface a single-layer, hydrophilic and optionally lubricious coating, like a catheter, guidewire, or a delivery device for an implant.

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The invention relates to a method for manufacturing a three-dimensional medical device from an acellular biological matrix characterized in that it comprises at least the following sequence of steps:

a/ wetting an acellular biological matrix with a liquid, and

b/ shaping the wet acellular biological matrix so that it takes on a three-dimensional shape.

The invention also relates to the obtained three-dimensional medical device and its use as an implant.

Methods of inactivating microbiological contamination described herein use a textile or membrane which can generate a contamination-inactivating amount of ozone or a reactive oxygen species. The textile or membrane includes first and second conductive layers and at least one ion conductive or porous intermediate layer positioned between the first and second conductive layers. The textile or membrane can form part of a protective face mask, for example a medical or surgical face mask. A voltage effective to generate a microbiological contamination-inactivating amount of the inactivating species is applied across the intermediate layer of the textile or membrane.

The invention relates to a drug-coated balloon catheter and to a method for producing the same. The balloon of the catheter includes (i) a main membrane, and (ii) an asymmetrical polymer membrane which is applied to an outside of the main membrane and into which at least one pharmaceutical active ingredient is introduced.

An implant comprises a substrate and a coating on a surface of the substrate, and the coating comprises silicon nitride and has a thickness of from about 1 to about 15 micrometer. A method of providing the implant comprises coating a surface of the implant substrate with the coating comprising silicon nitride and having a thickness of from about 1 to about 15 micrometer by physical vapour deposition.