Hemostatic devices for promoting blood clotting can include a substrate (e.g., gauze, textile, sponge, sponge matrix, one or more fibers, etc.), a hemostatic material disposed thereon such as kaolin clay, and a binder material such as crosslinked calcium alginate with a high guluronate monomer molar percentage disposed on the substrate to substantially retain the hemostatic material material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood to accelerate clotting. Moreover, when exposed to blood, the binder has low solubility and retains a majority of the clay material on the gauze. A bandage that can be applied to a bleeding wound to promote blood clotting includes a flexible substrate and a gauze substrate mounted thereon.

The present invention addresses the problem of providing a plasma spraying material with which it is possible to form an HAp film that has high hardness and is not susceptible to abrasion, even under conditions involving plasma spraying with low flame energy. In the present invention, an HAp powder having an average particle diameter (D.sub.50) of 15-40 μm and a pore volume of 0.01-0.30 cc/g at a pore diameter of 2000 nm or less as measured through mercury intrusion makes it possible to form an HAp film that has high hardness, is not susceptible to abrasion, and can be subjected to plasma spraying, even under conditions involving plasma spraying with low flame energy.

This disclosure describes manufacturing of a device configured to guide bone and tissue regeneration for a bone defect. A method may include receiving a three-dimensional digital model or scan representing an anatomical feature to be repaired, generating a simulated membrane using the three-dimensional model, the simulated membrane being configured to cover the anatomical feature to be repaired, generating a digital two-dimensional flattened version of the simulated membrane, and generating code or instructions configured to cause a three-dimensional printer or milling device to produce a trimming guide that includes an opening corresponding to the flattened version of the simulated membrane and that further includes a cut-out configured to hold a premanufactured membrane. The trimming guide may be operative as a guide for marking or cutting the premanufactured membrane through the opening while the premanufactured membrane is held in the cut-out.

An intravascular stent and method of making an intervascular stent having a hybrid pattern a. The hybrid pattern comprises a plurality of circumferentially self-expansible members comprising a plurality of interconnected, geometrically deformable closed cells, adjacent self-expansible members interconnected by a plurality of bridge members linking a first interconnection between two closed cells in a first self-expansible member to a second interconnection between two closed cells in a second self-expansible member, wherein the second interconnection is circumferentially offset and non-adjacent to the first interconnection.

Provided is an artificial blood vessel in which flexibility and a hemostatic effect required for an implantation procedure are appropriately secured. An artificial blood vessel 1 includes a base material 11 made of a fiber having a porous structure, and a coating layer 12 formed on a surface of the base material. The coating layer contains a hydrophilic polymer and a humectant, and a weight ratio of the humectant to the hydrophilic polymer is 0.1 wt% to 40 wt%.

Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability and are readily applied in coating processes a low temperatures that do not deform the device. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.

Example compliant hydrophilic coatings including a base coat and a lubricious top coat for coating a medical device including a flexible substrate. The coatings exhibit reduced cracking and peeling in response to deformation or expansion of the flexible substrate. Example techniques for coating a medical device including a flexible substrate with compliant hydrophilic coatings.

A system for forming surface modified substrates includes a laser system, and a laser processing chamber. A laser scanner automatically controls a position of the laser beam or an x-y translating stage upon which the laser processing chamber is mounted thereon for scanning the laser beam relative to a substrate of material (M) having a bulk portion and an outer surface integrated with the bulk portion, and a coating including metal organic molecules including at least one metal X or particles of metal X on the outer surface. At laser-heated spots atoms of X from the metal coating diffuse into the outer surface to form a modified surface layer including both M and X. The modified surface layer has a thickness of 1 nm, and a 25° C. electrical conductivity ≥2.5% above or ≤2.5% below a 25° C. electrical conductivity in the bulk portion.

Methods for forming an implantable layer onto a staple cartridge are disclosed.

Provided are a drug layer applying device and a method for forming a drug layer which can quickly and easily apply or provide an appropriate amount of a drug on a surface of a medical instrument such as a balloon. A drug layer applying device that applies a drug layer on a surface of a balloon to be inserted into a living body, includes: a deformable porous body capable of holding a coating solution containing a drug and a solvent; a removal unit that is flexibly deformable and arranged alongside the porous body; and a holding base that holds the porous body and the removal unit.