A cable includes a sheath, and a coating film covering a circumference of the sheath. The coating film adheres to the sheath. The static friction coefficient of a surface of the coating film is smaller than the static friction coefficient of a surface of the sheath. The adhesion strength between the sheath and the coating film is 0.30 MPa or more.

A parent artery occlusion (PAO) device which provides for immediate occlusion of a cerebral artery to isolate a defect. The PAO device includes a self-expanding wire-frame prolate structure which is partially covered with an ePTFE membrane.

Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability and are readily applied in coating processes a low temperatures that do not deform the device. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.

A proto-device for implantation into soft tissue comprises an oblong device body, biodegradable microfibres adhesively attached to the body, a rigid matrix of biocompatible material enclosing the body and the microfibres. The biocompatible material is dissolvable and/or degradable in aqueous body fluid at a rate substantially superior to the rate of microfibre degradation. The proto-device is one of proto-microelectrode, proto-optical fibre, proto-polymer tube for drug delivery, proto-electrical lead, proto-encapsulated electronics. Also disclosed are uses of the proto-device and methods for its implantation and manufacture.

Medical articles formed from ionically bonding an ionic compound and an active agent provide enhanced properties. The ionic compound comprises an ionic additive incorporated into a base polymer. The ionic additive may be one or more of an anionic additive, a cationic additive, and a zwitterionic additive. Medical articles herein have antimicrobial, anti-fouling, and/or antithrombotic characteristics.

A titanium superhydrophobic surface comprising a coating of a perfluorosilane on contiguous titania micrograins surrounded by crevices, the micrograins comprising a topography of nanopits shaped by contiguous peaks and valleys. The superhydrophobic surface has significantly increased hemocompatibility and enhanced antibacterial properties compared to an unmodified titanium surface. The increased hemocompatibility was confirmed by reduced platelet adhesion, reduced leukocyte adhesion, and reduced thrombus formation. The surface is prepared by a facile hydrothermal treatment of a titanium surface with sulfuric acid, leading to the formation of a unique micro-nano surface topography. The superhydrophobic surface was then achieved by coating the micro-nano titanium surface with a low energy silane using physical vapor deposition.

A surgical implant with anti-adhesive, antibacterial and hemostatic properties to use in hernia repair. The implant includes: a) Bilayer intraperitoneal mesh, having biocompatible, antibacterial, hemostatic and anti-adhesive properties including combination of biocompatible non-degradable or semi-degradable mesh. The mesh is prepared with blend system of biodegradable polyester-based polymers/chitosan mixture in hexafluoro isopropanol (HFIP) solvent and coated on polypropylene (PP) layer as nanofibers via electrospun technique; and, b) Double and/or triple-layer extraperitonal composite mesh, was prepared with blend systems of biodegradable polyester-based polymers and/or polysaccharides formed on PP/polyester woven material via different coating methods.

Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability, and are readily applied in coating processes. The present invention is also directed to a novel platinum catalyst for use in such coatings. The catalyst provides for rapid curing, while inhibiting cross-linking at ambient temperatures, thereby improving the production pot life of the coatings.

Anti-biofilm osseointegrating implantable devices that can elute therapeutic ions such as silver are provided by powder coating implantable substrates such as metal substrates. The polymer includes a polyarylether ketone such as PEEK, and zeolite, and the zeolite may be loaded with one or more therapeutic metal ions, such as silver, copper and/or zinc that exhibit antimicrobial properties. The devices, when implanted into a body and exposed to bodily fluid, may elute antimicrobial metal ions in a therapeutically effective amount.

Coatings, materials, and devices with biohealing properties are described. A biohealing coating may include a base material and biohealing particles. The base material may include a polymer. The biohealing particles may include one or more of metal particles, alloy particles, metal oxide particles, carbon particles, carbide particles, and nitride particles. The biohealing coating may be applied to an implantable device. A biohealing material may include a base material in bulk form and biohealing particles. The biohealing material may be used to manufacture an implantable device. An implantable device may include one or both of a biohealing coating and a biohealing material.