An implant can include a plurality of polymeric fibers associated together into a fibrous body. The fibrous body is capable of being shaped to fit a tracheal defect and capable of being secured in place by suture or by bioadhesive. The fibrous body can have aligned fibers (e.g., circumferentially aligned) or unaligned fibers. The fibrous body can be electrospun. The fibrous body can have a first characteristic in a first gradient distribution across at least a portion of the fibrous body. The fibrous body can include one or more structural reinforcing members, such as ribbon structural reinforcing members, which can be embedded in the plurality of fibers. The fibrous body can include one or more structural reinforcing members bonded to the fibers with liquid polymer as an adhesive, the liquid polymer having a substantially similar composition of the fibers.

The disclosed medical device has high visibility on non-woven fabric having a color such as green, blue, or the like, excellent identifiability from other medical devices having a color such as green, blue, or the like, and high surface smoothness. The medical device comprises an elongated body and a resin layer for covering at least a proximal portion of the elongated body, in which the resin layer has a first layer which includes a first fluororesin, titanium oxide, and a dispersant, and a second layer which is formed on the first layer and includes a second fluororesin. The content of the titanium oxide is 30% by weight or more relative to the solid content of the first layer, and an acid value of the dispersant is 20 to 90 mg/KOH.

A material for a bone implant includes a surface which contains a metal-based material, a metal alloy, an oxide ceramics material, a polymer material, a composite material or combinations thereof. An organic polymer matrix is covalently bonded to the surface. A substance is linked with the organic polymer matrix for binding embedded metal ions or nanoparticles. A calcium phosphate is embedded in the organic polymer matrix. As a result, the material for the bone implant is biocompatible and corrosion can be slowed down or even prevented.

A biocompatible polymer hybrid nanocomposite coating on a surface of a substrate, such as titanium and its alloys. The coating can be achieved by an electrostatic spray coating, preferably using ultra-high molecular weight polyethylene (UHMWPE) as a matrix for the coating. For example, up to 2.95 wt. % carbon nanotubes can be used as reinforcement, as can up to 4.95 wt. % hydroxyapatite. A dispersion of CNTs and HA in the coating is substantially uniform. The tribological performance of such coatings include high hardness, improved scratch resistance, excellent wear resistance, and corrosion resistance compared to pure UHMWPE coatings.

Described herein are co-doped magnesium oxide nanocomposites with antimicrobial properties for industrial and biomedical applications. Methods of inhibiting microbial and/or eliminating microbial growth with the disclosed compounds on biological and inanimate surfaces are also described.

An intracardiac echocardiography catheter includes a shaft and an ultrasound transducer at a distal end of the shaft. The ultrasound transducer includes an outer polymeric encapsulant layer and a nanocoating applied to the outer polymeric encapsulant layer. The nanocoating is configured to provide increased surface lubricity and self-cleaning properties to the ultrasound transducer.

An article having an antibacterial surface having an antibacterial surface having the nano scale flakes or platelets arranged essentially aligned to each other and extending out from said surface with a length in the range of 0.5-30 microns. The antibacterial surface is produced by processing a mixture of a polymer matrix material and a filler material comprising the nanoscale flakes or platelets by pressing the mixture through a die while heated to a temperature above a melting temperature of the polymer matrix material. Hereby, the nano scale flakes or platelets become aligned, with their longitudinal directions being oriented in substantially the same direction. A surface of the processed mixture which is oriented essentially perpendicularly to the longitudinal directions of the nano scale flakes or platelets is then etched or ablated to partly expose the nano scale flakes or platelets, thereby making the surface antibacterial.

The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 μm; providing a dispersion of bioactive ceramic particles of particle size at most 10 μm in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent. Further disclosed is an osteoconductive polymer article for use as an orthopedic implant, which article is made from a biocompatible, non-biodegradable polymer and comprises a non-flat surface with roughness Ra of at least 5 μm, wherein bioactive ceramic particles of particle size at most 10 μm are partly embedded in the polymer at the surface of the article. The methods exhibit benefits in ease of modifying a surface layer with bioactive particles, applying mild conditions and not requiring use of further additives or post-treatments, or without significantly affecting bulk polymer properties, and result in an orthopedic implant article having particles adhering to the surface while still being accessible for interaction with surrounding tissue or fluid.

A variety of nanoparticles or microparticles may be used to treat diseases such as restenosis or blood clots. For example, a nanoparticle or microparticle may include a core having a biodegradable polymer, an exterior having hydrophilic moieties. and a therapeutic agent. The nanoparticles may include targeting moieties that target the nanoparticle or microparticle to an arterial lesion. The nanoparticle or microparticle may include an exterior shell around the core to increase stability of the nanoparticle or microparticle. The nanoparticle or microparticle may include a magnetic particle to allow targeted delivery of the nanoparticle or microparticle via a magnetic field. The nanoparticles or microparticles may be coated on a medical device, such as a catheter balloon or a stent, or may be delivered systemically or locally to patients in need thereof.

A coating film is provided in a cable, a medical hollow tube, a molded article and a hollow tube. The coating film is formed from a rubber composition including a rubber component and fine particles. A static friction coefficient on a surface of the coating film is 0.5 or less. When the coating film is subjected to a testing such that a long fiber non-woven fabric including cotton linters including an alcohol for disinfection with a length of 50 mm along a wiping direction is brought contiguous to the surface of the coating film at a shearing stress of 2×10.sup.−3 MPa to 4×10.sup.−3 MPa, followed by wiping off the surface of the coating film at a speed of 80 times/min to 120 times/min and 20,000 repetitions thereof for a wiping direction length of 150 mm, a difference (an absolute value of a difference) between the static friction coefficients of the coating film before and after the testing is not greater than 0.1.