The present disclosure provides a coating apparatus and method for applying a coating of a therapeutic agent, comprising an openable and sealable device compartment, a therapeutic agent positioned in communication with the device compartment, a thermal source for vaporizing the therapeutic agent, and a vacuum source in fluid communication with the device compartment.

The disclosure relates to a central venous catheter, preparation method thereof and a medical device having the same. The central venous catheter comprises a tube body and a coating formed on the surface of tube body, coating being formed of a coating composition comprising at least one photosensitive functional compound and at least one photocurable polymer. The central venous catheter of the disclosure can prevent thrombosis, dissolve primary thrombus, and possess super-lubricated surface and firm coating bonding.

A urinary catheter including a hydrophilic coatings on the outer surface of the catheter tube wherein the hydrophilic coatings comprises a hydrophilic polymer and a diacrylate compound have a number average molecular weight between about 200 and about 600.

The present invention relates to compounds for medical use in the treatment or in the prevention or in the diagnosis of arterial or venous thromboembolism.

Provided are a flexible tube for an endoscope, the flexible tube having good elasticity, being capable of sufficiently maintaining adhesiveness between a flexible-tube base and a polymer cover layer covering the flexible-tube base even when a bending operation is repeated, and being less likely to undergo a decrease in elasticity even when the flexible tube is repeatedly heated, an endoscopic medical device including the flexible tube for an endoscope, and methods for producing the flexible tube and the endoscopic medical device.

The flexible tube for an endoscope has a flexible-tube base containing metal as a constituent material, a porous layer on the flexible-tube base, a primer layer on the porous layer, and a polymer cover layer on the primer layer. The polymer cover layer includes at least one compound of a polyamide, a polyester, a polyurethane, or a polyolefin on a side in contact with the primer layer.

Embodiments of the present disclosure pertain to implantable medical devices that are operational for mitigating radiofrequency (RF)-induced heating. The implantable medical devices generally include a ferrite material that is associated with at least one component of the implantable medical device and operational to reduce the RF-induced heating of the implantable medical device. Additional embodiments of the present disclosure pertain to methods of mitigating radiofrequency (RF)-induced heating of an implantable medical device by applying a ferrite material to at least one component of the implantable medical device. Thereafter, the ferrite material reduces the RF-induced heating of the medical device. In some embodiments, the methods of the present disclosure also include a step of implanting the implantable medical device into a subject, such as a human being.

Polymeric materials that are blends of polymers having differing water solubility rates are disclosed. The blends may be incorporated into at least a portion of a medical devices such as the shafts of flushable urinary catheters to provide suitable catheter stiffness/flexibility and catheter disintegration in water receptacles such as toilets. The blended material may provide the substrate of the catheter shaft or may provide one or more layers of the catheter.

A biocompatible Mg—P coating on the surface of a zinc-based biomedical material, and a preparation method and use thereof are disclosed. In the method, zinc and a zinc alloy are first subjected to surface pretreatment and then soaked in a phosphate solution at a constant temperature to form the Mg—P coating through chemical liquid deposition (CLD). The control on the composition, thickness and surface morphology of the coating is realized by using the CLD method. The biocompatible Mg—P coating has a thickness of 0.5 μm to 50 μm, is dense and uniform, and comprises a main component of zinc-magnesium-phosphate and a small amount of zinc phosphate.

A hybrid scaffold is disclosed which is made of materials that define peripheral layers designed to interface with the tissues in the implant site and one or more intermediate layers. The materials are combined to give the scaffold mechanical properties suitable for withstanding the stresses of the implant site. The materials are fibroin for the peripheral layers and polyurethane combined with fibroin for each intermediate layer.

The present disclosure relates to drug eluting stents, methods of making, using, and verifying long-term stability of the drug eluting stents, and methods for predicting long term stent efficacy and patient safety after implantation of a drug eluting stent. In one embodiment, a drug eluting stent may include a stent framework; a drug-containing layer; a drug embedded in the drug-containing layer; and a biocompatible base layer disposed over the stent framework and supporting the drug-containing layer. The drug-containing layer may have an uneven coating thickness. In addition or in alternative, the drug-containing layer may be configured to significantly dissolve/dissipateldisappear between 45 days and 60 days after stent implantation. Stents of the present disclosure may reduce, minimize, or eliminate patient risks associated with the implantation of a stent, including, for example, restenosis, thrombosis, and/or MACE.