It has been discovered that iron-platinum ferromagnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to or embedded on to, medical devices and magnetized. The magnetized devices are used to attract, capture, and/or retain magnetically labeled cells on the surface of the device in vivo. The magnetic particles have an iron/platinum core. Annealing the Fe/Pt particle is very important for introducing a L10 interior crystalline phase. The Fe:Pt molar ratio for creation of the crystal phase is important and a molar range of 1.2-3.0 Fe to Pt (molar precursors, i.e. starting compounds) is desired for magnetization. The magnetic force as a whole can be measured with a “Super Conducting Quantum Interference Device”, which is a sensitive magnetometer. The overall magnetic force is in the range from 0.1 to 2.0 Tesla.

In some aspects, the disclosure pertains to injectable particles that contain at least one pH-altering agent that is configured to be released from the injectable particles in vivo, upon embolization of an intratumoral artery of a tumor with the injectable particles. In certain instances, the pH altering agent may be a basic agent having a pH value of 7.5, a buffering agent having a pKa value of 7.6 or more, or both. Other aspects of the disclosure pertain to preloaded containers containing such injectable particles and methods of using such injectable particles.

Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.

A simple, self-propelling particle system is disclosed that can deliver a cargo through flowing aqueous solutions. This disclosure provides a non-aqueous composition comprising: (i) particles formed of a carbonate salt and having an average diameter of about 100 μm or less; and (ii) an acid in solid form. The particles may be associated with a cargo molecule or particle. In mouse models of severe hemorrhage, the propelled particles are able to deliver a procoagulant enzyme and halt bleeding.

Aspects of the disclosure relate methods and synthetic scaffolds for regenerating hallow organs present in the respiratory system such as bronchus tissue.

The present disclosure relates to a ureteral stent and a preparation method thereof. The ureteral stent has at least one pre-coating formed on its surface and at least one hydrophilic lubricating coating formed on the pre-coating. Preferably, the pre-coating and the hydrophilic lubricating coating are formed by photocuring, thermal curing, chemical reaction, physical adsorption, crystallization or freezing. By means of the technical solutions of the present disclosure, a stable and firm coating is formed on the surface of the ureteral stent with a more complicated shape, the friction force (the friction force of the 30.sup.th cycle is small, and the friction force of the 30.sup.th cycle/initial friction force is kept within 2 times) of the ureteral stent is greatly reduced, and the lubricating performance is greatly improved.

The present disclosure provides folded, porous metal scaffolds that can be used as bone ingrowth features on medical implants.

There is disclosed a formulation suitable for the reduction or prevention of contamination of articles by microorganisms. The formulation includes at least one block copolymer of ethylene oxide and propylene oxide, at least one polyacrylic acid salt, and at least one propoxylated ethylenediamine compound.

In various embodiments, the present invention is directed to a drug-loaded amino acid based poly(ester urea) pouch or pocket sized to receive implanted devices that produces localized drug delivery. In some embodiments, the present invention is directed to an antibiotic-loaded L-Valine poly(ester urea) pouch or pocket that provides localized antibiotic delivery for CIEDs or other implanted devices. In one or more embodiments, the amount and rate of antibiotic release are dependent upon the thickness and loading concentration of the film. This dependence of release on thickness and loading concentration gives a handle to fabricate PEU-A pouches or pockets with any desired release profile that can locally deliver the therapeutically relevant amount of antibiotic.

In an embodiment, a method for loading a powder substance (10) into recesses (200) provided at a stent (S) surface, the method comprises: applying compression (100) to the powder substance (10) to thereby form tablets insertable into said recesses (200), inserting the tablets into the recesses (200) of the stent (S).