A method of producing an osteoinductive bone graft formed of a plurality of electrospun biodegradable fibers is disclosed. The method includes preparing a fibrous scaffold material formed of the plurality of electrospun biodegradable fibers, wherein the plurality of electrospun biodegradable fibers are entangled with each other to form a cotton-wool like structure having inter-fiber spaces forming a microenvironment for cell growth therein, and immersing the fibrous scaffold in a solution containing BMP-2 so that the BMP-2 is bound to the calcium particles exposed on the surface of the fibers. Area of binding site for BMP-2 on calcium particles exposed on a surface of the electrospun biodegradable fibers is adjusted by an amount of the calcium particles contained in the electrospun biodegradable fibers.

A demineralized bone matrix (DBM) scaffold product comprising a plurality of elongate demineralised bone fibres mechanically interconnected with one another in a regular and repeating pattern.

To provide a sliding member having improved wear resistance, and a method of manufacturing the sliding member. A femoral head ball according to an aspect of the present disclosure includes a composite ceramic containing alumina and at least one oxide other than alumina. A surface roughness Ra of the sliding surface when the femoral head ball slides against a constituent member constituting an artificial joint is not more than 0.01 μm. The sliding surface includes a plurality of recessed portions each having an opening diameter of not more than 2 μm.

Provided are compositions that can be employed for generating microporous gel systems. In some embodiments, the compositions include at least one sub-population of soft hydrogel microparticles with a Youngs modulus of less than 50 kPa and at least one sub-population of stiff hydrogel microparticles with a Young's modulus of greater than 90 kPa. Also provided are methods for generating the compositions, methods for treating bone and/or cartilage defects in subject using the disclosed compositions, methods for treating osteoarthritis using the disclosed compositions, and methods for providing orthopedic implants to subjects.

The present invention relates to a biodegradable alloy of Formula (I): Mg—Zn—X, wherein X represents —Ca—Mn or —Dy—Sr, wherein Zn is about 0.1 wt % to about 3.0 wt %, Dy is about 0.1 wt % to about 0.7 wt %, Sr is about 0.1 wt % to about 0.9 wt %, Ca is about 0.1 wt % to about 1.5 wt %, Mn is about 0.1 wt % to about 0.9 wt % and Mg is balance with impurities. The present invention further relates to a method for producing alloys, wherein the method comprises: (a) placing alloy components in a crucible, wherein the alloy components are placed in the crucible in a multilayer arrangement; (b) melting the alloy components at about 700° C. to about 850° C.; (c) stirring the melt of step (b) at about 400 rpm to about 500 rpm; (d) atomizing the melt of step (c) into millimeter size droplets using jets of inert gas; and (e) cooling and depositing the atomized alloy melt to obtain an ingot.

Disclosed herein are synthetic hydrogels suitable for delivering antimicrobial proteins, optionally in combination with bone regenerating agents to injured tissues. The hydrogels can include lysostaphin and one or more bone morphogenic proteins. The hydrogels are composed of a network of crosslinked hydrophilic polymers and adhesion peptides.

Described herein are compositions comprising a BMP-2 derived peptide conjugated to albumin for use in bone grafts. The composition may further include bone matrix, such as demineralized bone matrix (DBM).

A porous implant for repairing lost bone stock such as around a prosthetic joint is provided. The porous implant has a composite structure with a solid structure and a porous structure which may be formed monolithically by direct metal laser sintering. The solid structure includes a support structure which extends into the porous structure.

Provided herein is a 3D printing system and related compositions, and method of using such, that can produce a polymeric microfiber having embedded microspheres encapsulating an active agent with micron precision and high spatial and temporal resolution.

Disclosed is a biomedical β titanium alloy and a preparation method thereof. Its composition includes: Mo: 9.20-13.50%; Fe: 1.00-3.20%; Zr: 3.50-8.20%; Ta: 0-1.00%; the balance is Ti. The β titanium alloy is suitable for the laser additive manufacturing technology, and the prepared parts have a dense equiaxed grain structure with ultra-low grain size and a small number of columnar grain structures, which produces a fine-grain strengthening effect, and greatly improve the hardness and tribocorrosion performance of the alloy material. Also provided is a method for preparing a non-toxic, low-elasticity, and tribocorrosion resistant biomedical β titanium alloy material. A powder prepared from the above alloy components is subjected to a laser additive manufacturing technology to prepare a corresponding β titanium alloy with high-hardness, good tribocorrosion resistance and extremely low cytotoxicity. Moreover, the prepared material has good weldability and is a special metal alloy powder suitable for laser additive manufacturing.