The present invention relates to a coating composition for an in-vivo implantable prosthesis including a photoinitiator, a crosslinking agent, and a phosphorylcholine (PC) monomer having an acrylate group, a method of coating an in-vivo implantable prosthesis using the coating composition, and a cosmetic prosthesis coated with the crosslinked polyphosphorylcholine. An in-vivo implantable prosthesis coated with crosslinked polyphosphoryicholine may be manufactured by a simple method of applying a coating composition including a photoinitiator, a crosslinking agent, and a phosphorylcholine (PC) monomer having an acrylate group according to the present invention, and then irradiating UV rays. The crosslinked polyphosphorylcholine coating may provide hydrophilicity for the surface and may also remarkably reduce adsorption of proteins and fibroblasts, which may cause side effects such as capsular contracture. Further, the coating has strong enough not to peel off even under stimulation, and therefore, it is maintained under vigorous activity after implantation, thereby being usefully applied to the manufacture of an in-vivo implantable prosthesis with reduced side effects, such as breast prosthesis for cosmetic surgery.

The object of the invention is an acellular dermal matrix (1) comprising a solid and flexible sheet (10) which is provided with a plurality of through-openings (4) and is characterized in that the openings (4) have an elongated shape and, in particular, are forming slits (40). The openings are particularly suitable for opening in the form of a diamond.

A prosthetic implant with improved properties, suitable for implantation to the human body, comprising a composite comprising a base material and a plurality of additives, wherein the additives are selected from radiolucent additives and/or hyperechoic additives; or wherein the additives are selected to reduce the solvent concentration by between 5%-95%; or wherein the additives are selected to increase the elastic modulus by more than 20%; or wherein the additives are selected for combining these effects.

An apparatus for plasma treatment of an implant prior to installing the implant in a live subject is provided. The apparatus comprises an activation device and a portable container detachable from the activation device. The portable container comprises a closed compartment containing the implant immersed in a fluid, and the activation device comprises a slot configured to receive the portable container. The activation device further comprises an electrical circuit configured to be electrically associated with at least one electrode and configured to provide to the at least one electrode electric power suitable for applying a plasma generating electric field in the closed compartment, when the portable container is disposed in the slot. A container suitable for providing plasma treatment to a silicone implant and a method for preparing an implant for implantation surgery are also provided.

The embodiments disclosed herein relate to acellular matrix bioscaffold compositions comprising 1) a natural or synthetic polymer or blend of polymers; 2) collagen I (Col-1); and 3) collagen III (Col-3), wherein the ratio of Col-1 to Col-3 is between 0.5 and 3.5, wherein said bioscaffold is synthetic.

A method for producing an implant, the method includes providing a hollow biocompatible shell to be implanted in an organ of a patient. At least two filling materials are injected at one or more locations in the shell, such that a mixture of at least two of the filling materials is configured to produce gas bubbles within a bulk of the mixture. The gas bubbles are formed in the injected filling materials by heating the shell containing the mixture of the injected filling materials.

Resorbable implants, coverings and receptacles comprising poly(butylene succinate) and copolymers thereof have been developed. The implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing molding, pultrusion or other melt or solvent processing method. The implants, or the fibers preset therein, may be oriented. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings, receptacles and implants described herein, may be made from meshes, webs, lattices, non-wovens, films, fibers, foams, molded, pultruded, machined and 3D printed forms.

Tissue engineering devices and methods employing scaffolds made of absorbable material for use in the human body for tissue genesis and regenerative and cellular medicine including breast reconstruction and cosmetic and aesthetic procedures and supplementing organ function in vivo.

A breast shaping method using a barbed suture and a suture handling device. The breast shaping method includes inserting a tensioning barbed suture in medialmost and lateralmost portion of the inframammary fold from deep soft tissues (muscle/pericondrium-periostium to and along the subdermal layer of the inframammary fold, with an end portion of the barbed suture being left outside of the skin, thereby allowing the barbed suture to be tensioned, tensioning the end portion of the barbed suture arranged by the insertion of the barbed suture, so that the barbed suture pulls tissues of the subdermal layer, thereby lifting the inframammary fold and defining a nice indentation of the inframammary fold, and cutting the end portion of the barbed suture outside of the skin after the tensioning of the barbed suture.

Tissue engineering devices and methods employing scaffolds made of absorbable material for use in the human body for tissue genesis and regenerative and cellular medicine including breast reconstruction and cosmetic and aesthetic procedures and supplementing organ function in vivo.