Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.

The present invention relates to a patient-specific breast implant. More particularly, the present invention relates to a patient-specific breast implant which, when a breast-conserving surgery (BCS, also called lumpectomy or partial mastectomy) is performed to remove breast cancer while leaving as much normal breast tissue as possible, prevents deformation of breast that may occur due to the depression of breast skin or adhesions of remaining breast tissues after the BCS, shortens surgery time, and facilitates securing breast symmetry, thereby ultimately dramatically increasing the success rate of surgery and maximizing patient satisfaction.

The apparatuses and methods described herein relates generally to the field of active agent (drug) release from surgical grafts useful for soft tissue reconstruction, regeneration, or repair. More particularly, described herein are surgical grafts for soft tissue repair that include active agent that is released over time while advantageously matching the biomechanical properties of tissue during healing and recovery.

The present invention relates to a kit for preparing a customizable flesh simulating silicone gel or a flesh simulating silicone foam in particular for use in medical devices and a process for preparing said customizable flesh simulating silicone gel or silicone foam, in particular by using a 3D-printer.

A medical support device (1), for use in a woman's breast as an implant without incapsulated material, wherein the medical support device (1) comprises at least a wall shaped portion (2) having a first side (3), which shows a bulge out of a plane (4), and a second side (5) of the wall shaped portion (2) has a corresponding cavity, for example a dome shape, wherein the medical support device (1) comprises an elastomer. The device will keep endogenous tissue and/or fat and/or added material, such as hyaluronic acid, in place inside of deep gland tissue of a woman's breast by means of being attached to tissue, such as muscle. A method of producing and to use such a medical support device (1).

The present disclosure relates to a three-dimensional, degradable medical implant for regeneration of soft tissue comprising a plurality of volume-building components and a mesh component which is substantially made of monofilament or multifilament fibers, wherein each volume-building component is attached to at least one point on a surface of the mesh component, and wherein the projected surface area of each volume-building component, when projected on the surface of the mesh component, corresponds to a maximum of one tenth of the surface area of the mesh component.

The present disclosure provides tissue products produced from adipose tissues, as well as methods for producing such tissue products. The tissue products can include acellular tissue matrices for treatment of a breast.

The present disclosure relates to tissue matrix products. The products can includes tissue matrices that have holes or perforations located at certain positions to improve certain in vivo functions without substantial loss of strength or other important properties.

Disclosed are an artificial prosthesis and a method for manufacturing same. The artificial prosthesis includes a surface having a pattern formed thereon, the pattern comprising straight line shapes aligned in parallel with each other, and has the effect of reducing inflammation in a region implanted with the prosthesis, and effectively reducing capsular contracture side effects.

Disclosed herein are hydrogel devices and methods of making an use thereof. The devices can comprise: a continuous hydrogel matrix; a first chamber in the hydrogel matrix; and a second chamber in the hydrogel matrix; wherein the first chamber and the second chamber are each independently perfusable; wherein the first chamber is fluidly independent from the second chamber; wherein the first chamber is configured to be at least partially filled with adipose tissue; wherein the second chamber is configured to be at least partially filled with an oxygenated fluid; wherein the first chamber is defined by a first border; wherein the second chamber is defined by a second border; and wherein the first chamber and the second chamber are spaced apart from each other by an average distance of from 50 micrometers (microns, μm) to 800 μm as measured from the first border to the second border.