Provided are compositions and devices containing microspheres encapsulating one or more drug(s). The compositions and devices may be used to treat or prevent infection associated or caused by oral mucosal diseases, oral infections, oral conditions, dental conditions, or surgical recovery. The devices include, but are not limited to, splints, mouth guards, full dentures, partial dentures, or fillings. The devices may be manufactured from filaments that have a composition of the present disclosure. Also provided are methods of making and using the devices and compositions.

The present invention provides novel multi-functional (e.g., repelling biofilms, promoting formation of minerals, and having anti-infection properties) biocomposites and methods of use thereof. In various embodiments, the present invention also provides method for simultaneously treating biofilms, promoting mineralization, treating infection, or any combination thereof.

A method for promoting spine fusion inside intersomatic cages, comprising placing a fusion cage between two vertebral bodies, and injecting a bone cement paste inside said fusion cage, said bone cement paste containing a powder component comprising α-tricalcium phosphate (α-TCP) particles having an average size greater than or equal to 9 μm, and a liquid component comprising blood.

Therapeutic hydrogels in nonsurgical techniques to promote healing and regeneration of tissues whose structure and functions have been diminished due to chronic inflammatory disorders. More particularly, providing therapeutic and regenerative hydrogel compositions and their nonsurgical delivery to periodontal treatment sites to treat periodontal and peri-implant diseases. One delivery technique involves the injection of a sterile therapeutic biomimetic hyaluronic acid hydrogel tethered to at least one host modulating agent, such as tetrahydrocurcuminoids, THC, and at least one additional tissue regenerative agent, into the gingival connective tissue proper. The host modulating agent potentiates the periodontal tissue regeneration at the periodontal treatment site, while the biomimetic hyaluronic acid hydrogel serves in a dual capacity as a drug, a tissue regenerative agent carrier and as a biodegradable matrix around which the new connective tissue regenerates. Oral care gel and paste compositions may be used in a synergistic home-based oral care regimen.

The present invention relates to a biomaterial comprising at least one elastomeric matrix and a polysaccharide, and to uses thereof in the reinforcement, reconstruction and/or filling in of tissue defects, preferably the reinforcement, reconstruction and/or filling in of soft tissue defects and/or epithelial tissues, preferably skin and/or mucosal repair.

Two part implant for attachment of artificial teeth comprising a base body having a bone contact surface and a soft tissue contact surface. The soft tissue contact surface is at least partially hydroxylated or silanated which results in an improved soft tissue integration.

The dental coating composition of the present invention is suitable to coat dental prosthetics. The composition is a mixture of a (meth)acrylate dimer, a (meth)acrylate crosslinker, a photoinitiator, and a silicone surfactant, and optionally, a (meth)acrylate monomer with a heteroalkyl group, a colorant, special effects pigment, particles, and other additives. Incorporating particles in the dental coating formulation provides a “character” to the surface of the dental prosthetic, increasing the esthetic appeal of the prosthetic. The dental coating thus may make the parts of the dental prosthetic appear to approximate gingivae, or gum. The dental coating composition may be applied to a surface of an unfinished dental prosthesis prior to curing, to a partially cured prosthesis, or fully cured prosthesis.

There is provided a method for decreasing leakage of matter from an object to a surrounding, said object being coated with a coating at least partially applied on the object, said coating comprising an at least partially covering layer comprising silver, said object optionally comprising area(s) without said layer, said coating comprising metal particles applied on the layer and optionally on areas without said layer, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, niobium, neodymium and platinum and wherein the amount of the metal particles is in the interval 0.01-8 μg/cm.sup.2. Advantages include that leakage of matter such as latex allergens of metal ions can be reduced while the coating is both biocompatible and antimicrobial. Further, the blood clotting can be reduced.

A bleeding control device is provided. The device includes an elongate member with a holding portion and an application portion. A known amount of hemostatic solute within a solution is administered to the application portion and allowed to dry. The elongate member is then sterilized. The resulting bleeding control device may be used during medical procedures such as root canal procedures and others.

The invention relates to the application of a composition containing recombinant amelogenin and propylene glycol alginate (“PGA”) on to cut dentin tubules followed by installation of a definitive restorative in a single visit.