A dental device is improved in its ability to produce hydroxyl apatite by having a layer of mineral trioxide aggregate (MTA) deposited thereon. A tile of MTA is prepared, heat treated and sintered to produce a micronized tile of MTA that can then be deposited by physical vapor depositions, hot isostatic pressing, molding or other conventional technique.

A method for making a ceramic body comprised of a ceramic material having an inhibitory effect on bacterial growth is provided. A dental prosthesis may be made of a ceramic material that comprises a molybdenum-containing component on a portion of the prosthesis that contacts the gingival surface of a patient. In one method, a porous zirconia ceramic structure is shaped in the form of a dental prosthesis, and then infiltrated with a molybdenum-containing composition, before sintering to densify the ceramic structure.

The present invention relates in a first aspect to a method for coating a medical device suitable for implantation into an individual or for application on skin or mucosal tissue of an individual. Said method comprises the steps of applying to at least a portion of the surface of said device a coating layer whereby said coating layer comprises commensal microorganisms, like commensal bacteria, to form a biofilm on the at least portion of the surface of said medical device, further comprising the step of drying the biofilm coated on the surface of said medical device whereby the commensal microorganisms are eventually killed in case they were not applied as killed microorganisms in the step above, for obtaining a medical device having at least a portion of its surface coated with non-living commensal microorganisms In a further aspect, the coated medical devices obtainable by the method according to the present invention are provided. The coated medical devices according to the present invention are particularly useful in applications being mucosal tissue or a skin of an individual, like for use as an implant for dental use in the oral cavity. Finally, the present invention relates to the use of commensal bacteria like Streptococcus oralis for coating a medical device suitable for use as an implant into an individual or for application on skin or mucosal tissue of an individual.

Provided is a method of manufacturing a bone grafting substitute having a hole. The method of manufacturing a bone grafting substitute having a hole includes a biodegradable polymer preparation operation of preparing biodegradable polymer; a molding material preparation operation of preparing a molding material by mixing the biodegradable polymer with a bone material; a molding material injection operation of injecting the molding material into a hole forming mold for molding a bone grafting substitute having a hole; and a bone grafting substitute having a hole molding operation of drying the molding material injected into the hole forming mold at a predetermined temperature.

The invention is directed to an implantable structure comprising at least one biocompatible backbone scaffold and at least one biocompatible and biodegradable collagen membrane deposited thereon, including methods of its preparation and uses thereof in dental or orthopedic bone regeneration, dura repairs, hernia repairs and similar procedures requiring structural implants.

A biomimetic composite material includes a bioactive cement material, an autologous dentin matrix, and an inorganic nano-reinforcement material. A dental implant includes a body including a biomimetic composite material, wherein the biomimetic composite material includes a bioactive cement material, an autologous dentin matrix, and an inorganic nano-reinforcement material.

The present invention relates to a dental implant that contains a metal-organic framework (MOF) structure involving antibacterial metal ions, especially silver (Ag), thus can release long-term and controlled antibacterial metal ions and exhibits a long-term antibacterial/antimicrobial effect, has osseointegration capability and high biocompatibility and a method for preparing this dental implant.

The invention relates to the application of a composition containing recombinant amelogenin and propylene glycol alginate (“PGA”) on to cut dentin tubules followed by installation of a definitive restorative in a single visit.

The invention relates to the application of a composition containing recombinant amelogenin and propylene glycol alginate (“PGA”) on to cut dentin tubules followed by installation of a definitive restorative in a single visit.

A method for promoting growth of bone, periodontium, ligament, or cartilage in a mammal by applying to the bone, periodontium, ligament, or cartilage a composition comprising platelet-derived growth factor at a concentration in the range of about 0.1 mg/mL to about 1.0 mg/mL in a pharmaceutically acceptable liquid carrier and a pharmaceutically-acceptable solid carrier.