The present invention relates to a primer composition that may be applied to tissue in order to increase bond strength between the tissue and a patch, filler or a supporting material. The primer comprises a dithiol component and an allyl containing component together with a photo initiator.

Methods of manufacturing dental prosthesis/implants each to replace a non-functional natural tooth positioned in a jawbone of a specific pre-identified patient are provided. An example method includes the steps of receiving imaging data such as x-ray image data and surface scan data of a dental anatomy and/or a physical impression of the dental anatomy of a specific preidentified patient. The steps can also include forming a three-dimensional virtual model of at least portions of a non-functional natural tooth positioned in the jawbone of the specific pre-identified patient based on the imaging and surface scan data, virtually designing a dental implant based upon the virtual model, exporting the data describing the designed dental implant to a manufacturing machine, and custom manufacturing the dental implant for the specific patient.

The invention relates to a white, bacteria-resistant, biocompatible, adherent coating for an element which can be integrated in hard and soft tissue, in particular an implant, a screw or a plate, having a structure made from metalliferous gradient layers having varying oxygen content, wherein the band gap of the outer-most gradient layer is greater than 3.1 eV, wherein the outer-most gradient layer is crystalline and wherein the gradient layers comprise tantalum and/or niobium and/or zirconium and/or titanium.

An implant abutment according to the present invention is a dental implant abutment with an enhanced shock distribution function, the dental implant abutment comprising: an upper coupling portion that is an upper portion coupled to an artificial tooth; a lower coupling portion that is a lower portion coupled to a fixture, and an exposed portion that is exposed to the outside between the upper coupling portion and the lower coupling portion and has a plurality of flow grooves. By forming a plurality of grooves in the exposed portion of the implant abutment, the exposed portion of the implant abutment performs a shock distribution function as if it shakes elastically and distributes an occlusal force of teeth exerted to the implant, thereby providing a buffering function of relieving an impact on an area where the implant is inserted.

A bone cement includes a liquid component including a monomer configured to polymerize upon curing of the bone cement; and a solid component dispersed in the liquid component, the solid component including a powder of a polymer; an initiator; and a powder of a piezoelectric ceramic. A cell culture dish includes a base; and walls connected to the base to define an interior of the cell culture dish, wherein at least a portion of an interior surface of the base includes a piezoelectric material.

A biocompatible implant according to one aspect of the present disclosure includes a base and a calcium phosphate coating film located on a surface of the base and including silver. The calcium phosphate coating film includes a plurality of calcium phosphate particles located on a surface thereof, and a plurality of needle-like crystals located on a surface of the plurality of calcium phosphate and the plurality of needle-like crystals are located in a gap at an interface between adjacent calcium phosphate particles among the plurality of calcium phosphate particles.

A biological implant is implantable in a base being a part of a living organism. The implant includes an implant body including at least an outer circumferential surface containing a titanium alloy. The implant body is implantable in the base. Based on a first curve indicating a profile of the surface of the implant body obtained with a measurement length of 25.4 .Math.m and a second curve obtained by removing a long-wavelength component from the first curve at a cutoff value of 5 .Math.m in image processing performed on an image of a cut surface of the implant body perpendicular to the outer circumferential surface of the implant body, an arithmetic mean roughness value as a surface roughness value Ra of the outer circumferential surface calculated using the second curve is greater than or equal to 0.2 .Math.M.

Pharmaceutical compositions, more specifically poloxamer copolymer-based compositions and hyaluronic acid-based compositions, containing amelogenin, are useful for promoting periodontal or orthopedic soft or hard tissue regeneration, wound closure, and skin regeneration and rejuvenation. The composition can contain a non-biodegradable thermosensitive pharmaceutically acceptable poloxamer copolymer in an amount of 18% to 30% by weight; amelogenin in an amount of 0.005% to 3% by weight; a disaccharide in an amount of 0.05% to 5% by weight; and an amino acid selected from alanine, glycine, isoleucine, leucine, proline, valine, and a mixture thereof in an amount of 0.05% to 5% by weight.

Pure compressed diamond (PCD), grown in a laboratory, is laser-shaped into dental implants with high tensile strength, high compressive strength, high thermal conductivity, and which are harder than any other substance on earth. PCD is harder than ceramic zirconia and harder than titanium. Because PCD is pure carbon, it is also 100% compatible with carbon-based living tissue. Unlike titanium, it does not provoke an immune response. PCD implants readily integrate into human jawbone. This drastically reduces post-surgery bone loss.

Described herein are tissue grafts derived from the placenta with improved physical and biological properties. In one aspect, the tissue graft includes a first membrane comprising Wharton's jelly laminated with amnion, chorion, or a combination thereof. The presence of Wharton's jelly in the grafts enhances the performance of allograft amniotic-derived, caderivic allograft, xenograft, or alloplast soft tissue substitutes.