The present invention relates to implants comprising a deformable body formed of a polymer comprising functional groups capable of cross-linking to form a cross-link; said body provided in a first configuration which is cross-linked to a second configuration upon application of a selected stimuli; wherein said selected stimuli causes said cross-linking of said functional groups.

An implantable device includes a portion that is constructed such that at least a majority of the portion, as measured by volume, comprises Ti64 (Ti-6Al-4V) alloy. Additionally, the portion is bendable to a bend angle of at least about 50-degrees about a bend axis while maintaining structural integrity.

The invention relates to a kit of parts, consisting of compositions (C1) and (C2) in separate containers, for use in the treatment or prevention of osteoarthritis in a vertebrate, wherein: (a) composition (C1) is a liquid hydrogel formulation comprising a polymer gellant with chemically cross-linkable groups; (b) composition (C2) is an aqueous auxiliary formulation comprising either one or more dissolved cross-linkers Z having two or more reactive groups that can chemically cross-link the polymer gellant by forming covalent bonds; or comprising one or more dissolved compounds Y, selected from the group consisting of oxidant, oxidase, peroxidase and combinations thereof, that initiate or mediate chemical cross-linking of the polymer gellant; wherein said treatment comprises combining compositions (C1) and (C2) to form a liquid hydrogel composition (C3) and administering said liquid hydrogel composition (C3) to the synovial fluid or to the cavity of a synovial joint of the vertebrate, to form a cross-linked hydrogel (C4) in the synovial joint of the vertebrate; or wherein said treatment comprises in a first step administering one of the compositions (C1) or (C2) to the synovial fluid or to the cavity of a synovial joint of the vertebrate and in a second step administering the other of the compositions (C1) or (C2), to form a liquid hydrogel composition (C3) in the synovial joint of the vertebrate that reacts to a cross-linked hydrogel (C4).

A method for producing a sliding surface element on the basis of UHMWPE for a joint endoprosthesis includes mixing UHMWPE in powder form with 0.09 to 0.11% by weight of an antioxidant, compacting the UHMWPE mixed with the antioxidant into a molded body, manufacturing one or more sliding surface elements from the molded body by material-removing machining, and irradiating the sliding surface element by gamma radiation or X-ray radiation with a radiation dose of 25 to 45 kGy in order to crosslink the UHMWPE. The method can be practiced without thermal post-treatment of the irradiated sliding surface element.

Provided herein are compositions comprising collagen, dialdehyde starch, and at least one population of cells. Also, provided herein are methods of bioprinting and methods of producing cell-laden, three-dimensional scaffolds, comprising the compositions described herein.

An implantable medical device, for implantation in a mammal knee joint, comprising an artificial contacting surface adapted to replace at least one contacting surface of the knee joint and to be lubricated when implanted in said joint. The medical device further comprises a reservoir comprising a movable wall portion defining the volume of the reservoir, at least one inlet adapted to receive a lubricating fluid from the reservoir, at least one channel at least partly integrated in said artificial contacting surface, wherein the channel is fluidly connected with said at least one inlet for distributing said lubricating fluid to the surface of said artificial contacting surface. The medical device further comprises an operation device adapted to non-invasively transport said lubricating fluid from said reservoir to said artificial contacting surface, and an implantable injection port for refilling said reservoir, wherein the movable wall portion is moved when the reservoir is refilled, such that the volume of the reservoir is increased.

The present disclosure pertains to ionic polymer compositions, including semi.- and fully interpenetrating polymer networks, methods of making, such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging, for such articles.

Various embodiments disclosed relate to an implant including a crosslinked iodine-infused polyethylene. In various embodiments, the implant can be made by exposing the polyethylene to a source of iodine such that the polyethylene is infused with iodine. In various embodiments, a method of preventing microbe formation on or around an implant includes implanting a crosslinked iodine-infused implant comprising polyethylene, wherein iodine is released gradually from the implant after the implantation.

The invention relates to a method and a device for producing an implant, wherein a natural bone microstructure of a natural bone region is detected (S1), an implant region in the natural bone region is marked (S2), the detected bone microstructure in the marked implant region is analysed to determine reproduction parameters (S3), and on the basis of the determined reproduction parameters, an artificial microstructure for producing the implant is created (S4).

The present invention relates to a hydrogel composition prepared without using a binder. The composition is easy to inject into the human body and has a therapeutic effect on intraarticular lesions and inflammation. The hydrogel of the present invention, which is prepared without a binder, is degraded in an articulation for a long time due to the increased viscoelasticity thereof, thereby enjoying the advantage that the absorption time is prolonged. Therefore, when the hydrogel is used as an injection, its efficacy may be maintained for a long time. Furthermore, the hydrogel has no cytotoxicity, thus showing very high biocompatibility. Particularly when directly injected to an injured site in an articulation, the hydrogel has a therapeutic effect on the intraarticular lesion and inflammation in the corresponding site and thus may be advantageously utilized as a composition for prevention or treatment of an intraarticular lesion and as a viscosity supplement.