The present invention provides an active substance application insert (10, 110) for an implant (30), in particular a joint implant. The active substance application insert has a main body (11), an active substance chamber (12) formed in the main body, an application side (13, 113) which forms a front face of the active substance chamber, wherein the application side has a plurality of application openings (14, 114), and a securing means (15) with which the main body can be detachably secured in the implant. In a state in which the main body is inserted into the implant, the application side faces outwards relative to the implant, such that the application openings connect the active substance chamber to the environment of the implant. Furthermore, within the scope of the present invention an implant (30) with a recess (31) for receiving an active substance application insert (10, 110) is provided.

An implant is provided comprising a substrate having one or more nanoceria coatings coated at least partially thereon, wherein the one or more nanoceria coatings comprise surface cerium having a 3+/4+ oxidation state ratio such that the one or more nanoceria coatings exhibit catalase mimetic activity, superoxide dismutase mimetic activity, or both. Methods are provided for forming a nanoceria coaling. The coating has nanoceria having a surface cerium 3+/4+ oxidation state ratio such that such that the coating exhibits catalase mimetic activity, superoxide dismutase mimetic activity, or both. Also disclosed is a method of reducing degradation of an implant by placing nanoceria in proximity to a bone-implant interface.

An implantable medical device for implantation in a mammal joint having at least two contacting surfaces is provided. The medical device comprises; an artificial contacting surface adapted to replace at least the surface of at least one of the mammal's joint contacting surfaces, wherein the artificial contacting surface is adapted to be lubricated, when implanted in said joint. Furthermore the medical device comprises at least one inlet adapted to receive a lubricating fluid from a reservoir, at least one channel at least partly integrated in the artificial contacting surface in connection with the at least one inlet for distributing the lubricating fluid to the surface of the artificial contacting surface. The medical device could be adapted to be operable by an operation device to receive the distributed lubricated fluid from a reservoir.

The present invention concerns layered foamed polymeric materials lacking discontinuities at the interface between the layers and a preparation process thereof comprising the following steps: —providing a foamable polymeric material; —solubilising said one or more foaming agents in the foamable polymeric material under pressure and at a temperature greater than 20° C.; and —releasing the pressure instantaneously; where the solubilisation step is carried out with a pressure profile of said one or more foaming agents that is variable over time.

A prosthesis or implant device for use in joint or bone repair, or restoration of function, with improved surface hardness and depth of hardness and a process comprising treating a biocompatible alloy such that hardness and depth of hardness is improved.

A method of providing an anti-microbial coating on an object, comprises the steps of pre-treating the object in a first oxygen plasma to graft oxygen-based functional groups on the surface of the object by plasma enhanced chemical vapour deposition, coating the pre-treated object with a suspension of particulate graphene oxide to provide a graphene oxide coating on the object, treating the object in a hydrocarbon plasma to deposit an amorphous hydrocarbon film on the graphene oxide coating by plasma enhanced chemical vapour deposition, and treating the object in a second oxygen plasma configured to etch and flatten the coatings on the surface of the object. A prosthetic implant having a metal or metal alloy surface and an anti-microbial coating on all or part of the surface is also described.

Compositions comprising a reverse-temperature sensitive hydrogel comprising a biopolymer such as a polysaccharide and a synthetic polymer, and a compound in an amount that reversibly inhibits respiratory enzyme complex I, and methods of using the composition, are provided.

A combined fully organic high molecular material artificial knee joint, comprising a femur condyle (2), a tibia holder (4) and a tibia liner (3), the femur condyle (2) and the tibia holder (4) being formed by polyether ether ketone (PEEK) or derivatives thereof, and the tibia liner (3) being formed by ultra-high molecular weight polyethylene (UHMWPE). The tibia holder (4) comprises a platform (6) and a stable wing positioning portion (5) vertical thereto; upper and lower ends of the tibia liner (3) are jointed with the femur condyle (2) and the platform (6) respectively; the femur condyle (2) buffers a slide surface of the tibia liner (3); and the tibia holder (4) can finely move relative to a fixed surface of the tibia liner (3), and buffering of the femur condyle (2) against the slide surface of the tibia liner (3) matches fine movement of the tibia holder (4) relative to the tibia liner (3). Main parts of all implant components of the artificial knee joint are formed by high molecular materials, thereby relieving allergy and toxicity problems probably caused by metal and metal corrosion; PEEK elastic modulus matches a natural bone, thereby relieving a stress shield problem; a wearing problem is greatly relieved by means of the combination of buffering of the PEEK femur condyle (2) against the slide surface of the UHMWPE tibia liner (3) and fine movement of the tibia holder (4) relative to the fixed surface of the UHMWPE tibia liner (3); and meanwhile, by adding enhancement and developing components, the practicality is further improved.

The present invention comprises a polymeric based femoral and/or tibial component implant to be used in total knee replacement/arthroplasty procedures serving to provide increased wear resistance, enhanced physiological response at the bone/implant interface, and decreased stress-shielding. The implant can be made via additive manufacturing. The articulating surface of the implant may be implemented in without any additive or in a form containing an additive for improved tribological response. Further, the device disclosed herein contains an interfacial surface which is in contact with the native bone (i.e., bone/implant interface) which may exist in its pure form, containing a bioactive additive. The implant has a porous morphology on the bone/implant interface for improved biological response and improved fixation. The depth of the additives and the topographical morphology therein are controlled via techniques disclosed herein.

The present disclosure provides compositions and methods for repairing cartilage defects.