The invention provides a method for lubricating one or more surfaces, comprising applying gel-phase liposomes onto said one or more surfaces, wherein the temperature of said surface(s) at the time of lubrication is below the phase transition temperature T.sub.m of said liposomes. The method can be used for lubricating non-biological surfaces, and also for lubricating the surfaces of a biological tissue in a mammalian subject, e.g., for treating joint dysfunction.

The present disclosure provides biomaterials and methods for preventing and minimizing progression of cartilage and/or connective tissue damage. Also provided herein are biomaterials and methods for alleviating and/or reducing the risk for developing arthritis (e.g., osteoarthritis) associated with joint injury and/or joint surgery.

A biological implant is implantable in a base being a part of a living organism. The implant includes an implant body including at least an outer circumferential surface containing a titanium alloy. The implant body is implantable in the base. Based on a first curve indicating a profile of the surface of the implant body obtained with a measurement length of 25.4 .Math.m and a second curve obtained by removing a long-wavelength component from the first curve at a cutoff value of 5 .Math.m in image processing performed on an image of a cut surface of the implant body perpendicular to the outer circumferential surface of the implant body, an arithmetic mean roughness value as a surface roughness value Ra of the outer circumferential surface calculated using the second curve is greater than or equal to 0.2 .Math.M.

Compositions and methods for the prevention and/or treatment of conditions involving disease or damage in mammalian cartilage and bone, using mesenchymal stem cells isolated with anti-integrin α10 antibodies are disclosed.

Pharmaceutical compositions comprising amphiphilic peptides are provided. The pharmaceutical compositions are useful in treating or preventing various orthopedic and dental-related infectious and/or inflammatory conditions.

The present disclosure relates to a three-dimensional, degradable medical implant for regeneration of soft tissue comprising a plurality of volume-building components and a mesh component which is substantially made of monofilament or multifilament fibers, wherein each volume-building component is attached to at least one point on a surface of the mesh component, and wherein the projected surface area of each volume-building component, when projected on the surface of the mesh component, corresponds to a maximum of one tenth of the surface area of the mesh component.

High density polyethylene polymers, including high molecular weight and ultrahigh molecular weight polyethylene polymers, are disclosed that are at least partially made from bio-based feedstocks. The bio-based feedstocks are selected so as to produce high purity monomers capable of producing high density polymers for use in high purity applications, such as in producing implants and porous membranes for lithium-ion batteries.

Provided is a glenoid implant system that includes a tray component that includes a bone-facing surface and a bearing-facing surface on opposite side of the bone-facing surface; and a bearing component that includes an articulating surface that is generally concave and a back side on opposite side of the articulating surface that is generally convex, wherein the articulating surface is configured for engaging a convex humeral head and the back side is configured for engaging the bearing-facing surface of the tray component thus enabling the bearing component to slide about on the tray component while the convex humeral head articulates against the articulating surface.

In one aspect, the disclosure relates to protective, anti-bacterial coatings for medical implants and methods of making the same. Also disclosed herein are methods for improving the anti-bacterial properties of a medical device coated with silicon carbide (SiC) or titanium nitride (TiN). Further disclosed herein are medical devices including an anti-microbial layer prepared by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Provided are thiol-ene polymer networks which can reduce the ROS species that contribute to delayed bone healing and fusion. Furthermore, patients that suffer from neuropathic comorbidities such as diabetes suffer from a diminished healing capacity. An increase in proinflammatory factors and the high presence of reactive oxygen species (ROS) present in diabetics are linked to lower fusion rates. To this end, there is a need for a clinically relevant bone graft to promote bone fusions in patients with neuropathic comorbidities. Incorporating thiol-ene networks for bone scaffolds has demonstrated increased osteogenic biomarkers over traditional polymeric materials and act as antioxidants. Thiol-ene networks offer improved bone grafts for diabetic patients by reducing the number of hydroxyl radicals associated with neuropathic comorbidities. These networks are particularly well suited in promoting healing in patients with Type II Diabetes or other conditions exacerbated by ROS-mediated damage.