The present disclosure provides for a photoredox-responsive material, processes of making the photoredox-responsive material, and methods of use thereof.

Biodegradable implants including an ECM material and methods for treating a pelvic floor condition are described. ECM particles can be present within or on the surface of a pelvic implant, such as a biodegradable mesh, a pouch, or a urethral stent. After implantation the implant can provide tissue support, degrade over a period of time, and deposit the ECM material in the implantation area for regeneration of tissue and long term benefit.

The present invention relates to a fibrous 3-dimensional porous scaffold obtained by electro-spinning for tissue regeneration and a method for preparing the same.

Provided herein are inks including decellularized extracellular matrix (dECM) particles and scaffolds made from the inks. Also provided are methods of making the scaffolds and applications for the scaffolds. In an embodiment, a porous scaffold comprises dECM particles and an elastomer, wherein the scaffold is planar having a thickness of about 100 μm or greater, the scaffold comprises irregularly shaped pores having a random orientation and distribution throughout the scaffold, and the scaffold is free of crosslinking between the molecular components of the scaffold.

Tissue compositions and methods of preparation thereof are provided. The tissue compositions can be used to treat or regenerate muscle tissue. The compositions can be configured to provide increased strength compared to other muscle matrices.

A fiber assembly includes multiple fibers and nucleic acid fragments that crosslink the multiple fibers, and the fibers are microtubules or actin fibers.

Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.

Provided herein are scaffolds and methods useful to promote the formation of functional clusters on a tissue, for example, motor endplates (MEPs) or a component thereof on skeletal muscle cells or tissue, as well as the use of scaffolds so produced for repairing a tissue injury or defect.

The present invention provides a series of injectable bionanocomposites that may be delivered via injection to various tissue repair sites including myocardial infarction, intervertebral disc reconstruction, reconstruction of skeletal muscle, and musculoskeletal applications, urinary incontinence, adipose tissue engineering, and orthopedic applications such as osteoporosis, and meniscus and articular cartilage repair.

A method of treating volumetric muscle loss (VML) injury involving the administration of a hydrogel that is free of biological cells and growth factors is described. The hydrogel can comprise a crosslinked hydrogel matrix further comprising heparin wherein the hydrogel can be administered to a subject in precursor form and allowed to crosslink in situ in a muscle injury site or administered in a lyophilized powder, sheet or disc form. The presently disclosed subject matter further describes lyophilized hydrogel matrix materials, such as sheets, wafers and powders, that can be used to treat VML injury.