An autologous bone graft substitute composition for inducing new bone formation, promoting bone growth and treating bone defects. The composition includes autologous blood; one or more analogs of an osteogenic bone morphogenetic protein selected from BMP-6, BMP-2, BMP-7, BMP-4, BMP-5, BMP-8, BMP-9, BMP-12, and BMP-13, and combinations thereof in a range of from 2 to 1000 μg per ml of autologous blood; and hydroxyapatite, tri-calcium phosphate, or a mixture thereof as a compression resistant matrix, the compression resistant matrix being provided in the form of particles having a particle size in a range of from above 74 to 8000 μm. Preferably, a ratio between the compression resistant matrix and the autologous blood coagulum is from 50 to 500 mg of the compression resistant matrix per mL of the autologous blood coagulum.

Provided herein is a composite material for use in orthopaedic applications, and an orthopaedic implant made from such material, the composite material comprising a polymeric matrix material and further comprising a filler material comprising TiO.sub.2 and reduced graphene oxide. Also provided herein is a cranial prosthesis comprising a peripheral frame portion defining an aperture, and a removable insert portion for closing the aperture. Further provided is a cranial prosthesis comprising a core layer and a first skin layer, the first skin layer having a lower porosity than the core layer. The medical materials and devices disclosed herein may provide improved materials for use in orthopaedic applications, prostheses which offer improved access for revision surgery, and prostheses which offer improved bone integration and mechanical properties.

Hard-tissue implants are provided that include a bulk implant, a face, pillars, slots, and at least one support member. The pillars are for contacting a hard tissue. The slots are to be occupied by the hard tissue. The at least one support member is for contacting the hard tissue. The hard-tissue implant has a Young's modulus of elasticity of at least 3 GPa, and has a ratio of the sum of (i) the volumes of the slots to (ii) the sum of the volumes of the pillars and the volumes of the slots of 0.40:1 to 0.90:1. Methods of making and using hard-tissue implants are also provided.

According to one example, a valve for an apparatus configured to mix bone cement is disclosed. The valve can include a base defining a first portion of a passage. The passage can be configured to allow a component of the bone cement through the valve. The valve can include a projection extending from the base to a base opposing end and forming a second portion of the passage that communicates with the first portion. The projection can have a frustoconically shaped surface that comprises one of an outer surface or an inner surface that forms a part of the second portion of the passage.

The present disclosure relates to injectable compositions capable of forming a scaffold in situ at an intervertebral disc site, the composition comprising: (a) a biocompatible polymer; and (b) a biocompatible solvent system in sufficient amount to solubilize the biocompatible polymer in sufficient degree to allow injectable delivery to a disc site.

Implantable devices for orthopedic, including spine and other uses are formed of porous reinforced polymer scaffolds. Scaffolds include a thermoplastic polymer forming a porous matrix that has continuously interconnected pores. The porosity and the size of the pores within the scaffold are selectively formed during synthesis of the composite material, and the composite material includes a plurality of reinforcement particles integrally formed within and embedded in the matrix and exposed on the pore surfaces. The reinforcement particles provide one or more of reinforcement, bioactivity, or bioresorption.

A bone graft composition comprising a calcium phosphate putty is provided. A method of repairing a bone defect in a patient by applying the bone graft composition is also provided.

An implant that can hold bone graft material, and receive support from adjacent tissues and structures. In one aspect, the implant has an attachment region to directly engage with adjacent tissues and structures. In another aspect, the implant is malleable and can be manipulated to conform to the adjacent tissues and structures.

A dynamic disc assembly has a superior end plate, an inferior end plate, and a core. The core has surfaces of an annular Fresnel shape and a linear Fresnel-like shape combined to control the dynamic range of motion (ROM) movement arranged to match anatomical ROM. The core is interposed between and held against interior surfaces of the superior end plate and the inferior end plate. The assembly further has a pair of coupling cords, one coupling cord at each lateral end of the superior and inferior end plates wherein each lateral end of each end plate has one or more cord connections attached and affixed to the coupling cord to form and retain the dynamic disc assembly.

A method for damaged viable disc regeneration has the steps of identifying the damaged viable disc and inserting a cannula via Kambin's Triangle to an edge of an outer annulus of the disc; introducing a trocar into the cannula and penetrating the trocar into a central region of nucleus pulposus; removing a tissue biopsy sample from the nucleus pulposus for pathology and removing additional degenerative tissue from the central region to create a void or space; withdrawing the trocar from the cannula and inserting a needle into the cannula to the void or space; and injecting a regenerative disc material through the needle into the void or space to repair the damaged disc.