A method of collecting mononuclear cells includes separating whole blood into plasma and cellular components, purifying the plasma through a plasma adsorption column to create purified plasma, combining the cellular components with the purified plasma to form a first mixture, and separating the first mixture into mononuclear cells and at least one component. Alternatively, whole blood may be flowed through an adsorption column to create purified whole blood, with the purified whole blood then being separated into mononuclear cells and at least one component.

Apparatuses and methods of using them to collect blood, are provided, by first ensuring that the patient's skin is properly cleaned, to prevent contamination of the collected blood. One feature is a blood collection device configured to collect blood from a patient. Another feature is a scrub timer integrated into the device and configured to indicate to a user a scrub time period prior to beginning a blood draw process. The scrub timer can be configured to audibly and/or visually indicate to a user the start and stop times of a scrub cleaning process. In one embodiment, the scrub timer can be restarted, either manually or automatically, if the scrub cleaning process is not followed properly.

The present invention relates to a blood bag system, a method for its manufacture, and a process for reducing pathogens and leucocytes in biological fluids in particular in therapeutic quantities of platelet concentrates (PC) contained in the blood bag system, using UV-light and agitation, wherein part of the plasma of the PC is optionally exchanged against a platelet additive solution.

A blood processing apparatus (1) comprises a measurement device (8) having a first chamber element (80) for measuring a haematocrit value of a blood fluid, the first chamber element (80) comprising a first inlet port (800) connectable to a first reservoir container (2) for allowing a flow from the first reservoir container (2) into the first chamber element (80) and a first outlet port (801) for allowing a flow out of the first chamber element (80), and the second chamber element (81) comprising a second inlet port (810) for allowing a flow into the second chamber element (81) and a second outlet port (811) connectable to a second reservoir container (3) for allowing a flow out of the second chamber element (81) towards the second reservoir container (3). The blood processing apparatus furthermore comprises a first pump mechanism (600) for pumping a blood fluid in a flow direction (F1) from the first reservoir container (2) towards the blood processing apparatus (1), and a second pump mechanism (610) for pumping a blood fluid in a flow direction (F2) from the blood processing apparatus (1) towards the second reservoir container (2). Herein, the first pump mechanism (600) is located upstream of the first inlet port (800) of the first chamber element (80) and the second pump mechanism (610) is located upstream of the second inlet port (810) of the second chamber element (81). In this way a blood processing apparatus comprising a measurement device is provided which in an easy and reliable manner allows for a measurement of in particular a haematocrit value in the incoming blood flow as well as the outgoing blood flow.

Provided are methods for preparing pathogen-inactivated whole blood and other pathogen-inactivated blood product compositions, as well as kits and compositions related thereto.

Filtration systems and methods using a pump and pressure sensor are provided for improved efficiency in fluid filtration systems. A filtration system includes a pre-filter container joined to a post-filter container by a filter line having a filter. To reduce the time required for filtration a pump and pressure sensor are included in a filter inlet flow path. The pump also is used to provide air management in the system via pre-filtration evacuation of air from at least the filter.

A blood component separation device includes a centrifuge bowl for separating a blood component from blood, a plasma bag for storing a plasma component, a platelet intermediate bag for storing high-concentration platelet liquid having high-concentration of platelets, and a temporary storage bag (also used as a buffy coat bag) for storing low-concentration platelet liquid having low-concentration of platelets. The blood component separation device performs control, from the second cycle onward, to mix the low-concentration platelet liquid stored in the temporary storage bag in the immediately preceding cycle with whole blood to supply the mixed liquid to the centrifuge bowl. An amount of high-concentration platelet liquid to be collected in the platelet intermediate bag in the first cycle is set to be smallest among all cycles, and an amount of high-concentration platelet liquid to be collected in a last cycle is set to be greatest among all the cycles.

A blood processing apparatus (1) comprises a measurement device (8) having at least one chamber element (80, 81) for receiving a blood fluid, wherein the at least one chamber element (80, 81) extends along a longitudinal axis (L) and comprises a circumferential wall (804, 814) extending about the longitudinal axis (L), a bottom wall (803, 813) and a top wall (805, 815) together defining a flow chamber (802, 812), the at last one chamber element (80, 81) further comprising an inlet port (800, 810) for allowing a flow of a blood fluid into the flow chamber (802, 812) and an outlet port (801, 811) for allowing a flow of a blood fluid out of the flow chamber (802, 812). The blood processing apparatus (1) further comprises a holder device (9) for holding the measurement device (8), the holder device (9) comprising a base (90) having a reception opening (900) for receiving the measurement device (8) and a closure element (91) movably arranged on the base (90) for locking the measurement device (8) in an inserted position in the reception opening (900). An ultrasonic sensor element (92, 93) of the holder device (9) is arranged on the base (90) and adapted to produce an ultrasonic sensor signal (P) for measuring a haematocrit value of a blood fluid in the flow chamber (802, 812). Herein, the ultrasonic sensor element (92, 93), in the inserted position of the measurement device (8), faces the bottom wall (803, 813) of the at least one chamber element (80, 81) for transmitting the ultrasonic signal (P) into the flow chamber (802, 812) through the bottom wall (803, 813). In this way a blood processing apparatus comprising a holder device for a measurement device is provided which allows to easily insert the measurement device into the holder device and allows for a reliable measurement of, in particular, a haematocrit value of a blood flow through the measurement device.

A tubing set for use in a blood processing apparatus comprises a measurement device (8) having at least one chamber element (80, 81) for measuring a haematocrit value of a blood fluid, wherein the at least one chamber element (80, 81) extends along a longitudinal axis (L) and comprises a circumferential wall (804, 814) extending about the longitudinal axis (L) and encompassing a flow chamber (802, 812), the at last one chamber element (80, 81) further comprising an inlet port (800, 810) for allowing a flow of a blood fluid into the flow chamber (802, 812) and an outlet port (801, 811) for allowing a flow of a blood fluid out of the flow chamber (802, 812). The tubing set furthermore comprises an inlet-side tube section (21, 31) connected to the inlet port (800, 810) and an outlet-side tube section (22, 30) connected to the outlet port (801, 811). Herein, the inlet port (800, 810) and the outlet port (801, 811) are arranged on the circumferential wall (804, 814) and are displaced with respect to each other along the longitudinal axis (L). In this way a tubing set comprising a measurement device is provided which in an easy and reliable manner allows for the measuring of a haematocrit value of a blood fluid.

A method for the filling of containers with autologous fresh blood components, comprising the following phases of: a) providing an equipment (1) defining a transit channel (3) having at least a first gap (3a) associated with an empty syringe (4) or the like, at least a second gap (3b) associated with a bag (5) or the like containing an autologous fresh blood component and at least a third gap (3c) connected to a plurality of containers (6) to be filled; b) insulating the second gap (3b) from the third gap (3c) and placing in communication the first gap (3a) with the third gap (3c); c) suctioning the air contained in the containers (6) to be filled by means of said syringe (4) so as to define a vacuum inside them; d) insulating the first gap (3a) from the third gap (3c) and placing in communication the latter with the second gap (3b), the containers suctioning the contents of the bag (5) due to the effect of the vacuum defined inside them.