A system with container volume tracking includes a pump receiving a line connected to a tracked container, an air sensor to detect air in the line, and a controller coupled to pump and sensor. The controller is configured to monitor pump operation, and determine a volume removed from the container based thereon. If the volume removed is less than a first percentage of a target volume and there is air, continue operation after an air purge. If the volume removed is more than the first percentage and less than a second percentage and if there is air, prompt the user for an input, and continue operation after an air purge if a first input is received or end operation if a second input is received. If the volume removed is more than the second percentage and if there is air, end operation.

A cell processing system includes a processor connectable to a source container filled with a biological fluid, the processor including a separator configured to separate the biological fluid from the source container into at least two streams according to a process including at least one process parameter, and a controller coupled to the processor and an input. The controller is configured to receive the at least one process parameter, to evaluate the process using the at least one process parameter before performing the process, and to carry out one or more actions based on the evaluation, such as providing an output estimate to the operator, preventing the process from being performed according to a comparison between a calculated condition and a control, or providing an error indication to the operator according to the calculated condition and a measured in-process condition.

A blood component separator (1) includes a blood storage vessel (20) that includes a first storage part (21) and a second storage part (22), a slider (30) movable from the first storage part to the second storage part, and a flow path (40f) for communicating an inside and an outside of the storage vessel. When the slider is in the first storage part, the first storage part and the second storage part are in communication with each other. When the slider is inserted into the second storage part, a liquid-tight seal is formed between the slider and the inner peripheral surface of the second storage part and the communication between the first storage part and the second storage part is blocked by the slider. The slider is movable in the second storage part while maintaining the liquid-tight seal between the slider and the inner peripheral surface of the second storage part. As the slider enters the second storage part, the blood component in the second storage part is pushed out of the storage vessel through the flow path.

A tray for processing platelet rich fibrin includes a base having at least one alignment structure, a screen attachment having at least one alignment structure for engagement with the base, and a lid having at least one alignment structure for engagement with the base and the screen attachment. The screen attachment includes a screen offset between the top and bottom surface of the screen. When the screen attachment is placed on the base with the top surface facing upward, the lid is configured to compress a fibrin clot placed on the screen to a first thickness, and when the screen attachment is placed on the base with the bottom surface facing upward the lid is configured to compress a fibrin clot placed on the screen to a second thickness different from the first thickness.

A system for processing fluids and filling a container with a product includes a disposable fluid circuit and reusable hardware configured to accept the disposable fluid circuit. The disposable fluid circuit includes a spinning membrane separator, first and second syringes, and a flow control cassette. The reusable hardware includes a drive coupled to the spinning membrane separator, first and second syringe pumps, the first and second syringes coupled to the first and second syringe pumps respectively, and a controller. The system also includes a syringe pump for filling low-volume containers, which syringe pump may be one of the first and second syringe pumps, or may be a third syringe pump. The syringe pump for filling low-volume containers may include a filtered vacuum/pressure source and a position detector.

System and method for pathogen inactivation with UV-C light (employed by itself or in addition to filtering out particulates rom the flow of air reaching the user) by delivering, into a lightguide portion of the air inactivation chamber of the system, a dose of ultraviolet radiation sufficient for at least one log reduction level of the pathogen while, at the same time, multiply reflecting the light inside the chamber to increase the irradiance of inactivating light several fold (up to 5×, or even up to 8.6×) as compared to that delivered to the chamber.

A device for separating blood into a plurality of blood components by centrifugal force includes a first chamber for receiving a blood bag filled with blood to be separated. Each separated blood component is located in a separate portion of the blood bag according to its specific weight. A second chamber receives at least one component bag to be filled with a blood component. The component bag has an inlet opening connected to an outlet opening of the blood bag by a line that has a controllable valve. A displacement body in the first chamber exerts a pressing force onto the blood bag. A control unit opens the valve until a blood component passes into the component bag as a result of the pressing force. The displacement body generates the pressing force with the aid of the centrifugal force and/or with the aid of a spring force.

The embodiments disclosed herein generally relate to systems, devices and methods for the fractionation, isolation, extraction and processing of the adipose supernatant layer of a bone marrow aspirate. In particular, the various embodiments relate to systems, devices, and methods of obtaining, utilizing, and processing the adipose supernatant layer of a bone marrow aspirate as a source of mesenchymal stem cells.

Methods and systems for priming a disposable fluid circuit for the processing of a biological fluid are disclosed. The methods and systems allow for variable and configurable priming of the flow path(s) leading to one or more biological fluid source containers.

A computer-implemented method for approving a medical device disposable component used in a medical procedure comprising providing an identifiable feature on a medical device disposable component, wherein the identifiable feature comprises one or more photo-identifiable entities having a first emission pattern when in an unexcited state and a second emission pattern when in an excited state. The method also comprises illuminating the identifiable feature with an excitation light source to elicit the second emission pattern, detecting the second emission pattern and comparing the second emission pattern against a set of established reference emission patterns, and determining whether the medical device disposable component is approved based on comparison of the second emission pattern to the set of established reference emission patterns.