The present disclosure relates to Oxygen Reduction Disposable kits (ORDKit), devices and methods for the improved preservation of whole blood and blood components. The improved devices and methods for the collection of blood and blood components provide for whole blood and blood components having reduced levels of oxygen. The devices and methods provide for the rapid preparation of deoxygenated blood and blood components for storage that improves the overall quality of the transfused blood and improves health outcomes in patients.

Fluid processing assemblies and methods are provided for mononuclear cell collection. Mononuclear cells are separated from red blood cells in a blood separation chamber, with the mononuclear cells and then the red blood cells exiting the chamber via an outlet port. The mononuclear cells and then the red blood cells enter an outlet flow path that is in fluid communication with a mononuclear cell collection container. The outlet flow path includes a visual indicium, which an operator may use to determine the position of the red blood cells within the outlet flow path and when to end mononuclear cell collection by preventing fluid communication between the outlet flow path and the mononuclear cell collection container.

The inventive apparatus is a device for collecting a target volume of blood in a collecting bag connected to a collection needle with a flexible tube. The device has a plate for the collecting bag and a clamping device for clamping the flexible tube. The device also has a bearing element having a bearing surface, and a clamping element with a clamping surface. The clamping element is able to move between an open position in which the flexible tube positioned between the bearing and clamping surfaces is not deformed and a closed position in which the flexible tube positioned between the bearing and clamping surfaces is closed off. The device also has a control unit configured to determine the volume of blood collected and move the clamping element from the open position to an intermediate position, when the determined volume of blood collected reaches a predetermined volume.

Disclosed is a centrifugable syringe and syringe components for use in blood fractionation. Also disclosed is a method of blood fractionation using the syringe. The syringe comprises a substantially transparent barrel, a substantially transparent, elongated delineation neck, a plunger for drawing blood into and expelling blood from the barrel, and an adapter attached to the neck for enabling releasable connection of a selected device over an inlet/outlet opening in the neck. The delineation neck extends away from a distal end of the barrel. The barrel and the neck have respective axial bores in fluid flow communication with each other, the cross sectional area of the bore in the delineation neck being substantially less than the cross sectional area of the bore in the barrel. The selected device may be one of various devices including a capping device sealing the inlet/outlet opening of the neck, a needle device used during withdrawal of blood from a subject through the neck, or a hose device used to carry away delineated blood fractions from the syringe through the neck.

A system for separating biological material includes a centrifuge tube, a separation tube having an open bottom, a cap, and a separation medium disposable within the centrifuge tube and the separation tube. The centrifuge tube and the separation tube sealingly and releasably couples to the cap, such that, when coupled, the separation tube is positioned within the centrifuge tube. The cap is configured to facilitate and/or regulate air- or gas-flow between an area outside of the cap and an interior of the separation tube. When the separation tube is positioned within the centrifuge tube, the open bottom of the separation tube is submersed in the separation medium. The system also includes a hollow needle coupled to a means for regulating a flow of air, gas, or other matter. The needle is insertable through the cap or plug, and is used to facilitate the introduction of matter into the separation tube.

Apparatus, systems and methods are disclosed relating to certain aspects of blood processing, collecting or storing, including method and system for automated authentication, processing device with scanner, blood container with two dimensional barcode, blood collection containers, blood container label and related tracking method, integrated container system, and processing device with sterile connection device.

A method for collecting plasma includes determining the weight and hematocrit of a donor, and inserting a venous-access device into the donor. The method then withdraws blood from the donor through a draw line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate (1) a percentage of anticoagulant in the collected plasma component, and (2) a volume of pure plasma collected within the plasma collection container. The volume of pure plasma may be based, at least in part, on the calculated percentage of anticoagulant. The method may continue until a target volume of pure plasma is collected within the plasma collection container.

Provided is a loading tray assembly for housing a lyophilization container and a related system and method. The loading tray assembly includes a chassis including a contact void configured to facilitate direct contact between the attached lyophilization container and a lyophilizer shelf. The method includes securing a multi-part lyophilization container including a peelable seal on a lyophilization loading tray assembly, inputting a liquid into a non-breathable section of the lyophilization container, loading the tray assembly into a lyophilizer, freezing the liquid, applying heat energy and a vacuum, the vacuum causing an opening of the peelable seal and occluding the lyophilization container to isolate the frozen liquid.

A system for washing red blood cells, comprising a separator configured to separate a quantity of blood into concentrated red blood cells having a hematocrit of at least 60% and a volume of 150-250 mL, and a supernatant component. The system comprises a flow controller configured to remove the supernatant component to provide an initial red blood cell concentrate; combine 50-500 mL of an additive solution with the red blood cell concentrate to provide an intermediate red blood cell product intended for storage for 42 days or less; and wash the intermediate red blood cell product with a washing solution.

Apparatus and methods for concentrating platelet-rich plasma is described herein. One variation may generally comprise a tube having a length and defining a channel within and one or more ports located at a proximal end of the tube and in fluid communication with the channel. A plunger may slidably translatable within the channel while forming a seal against an inner surface of the channel and a float may have a pre-selected density and defining a concave interface surface, wherein the float is slidably contained within the channel such that the concave interface surface is in apposition to the one or more ports.