Modular blood product storage system for temperature-regulated storage of blood products with a temperature regulation unit for temperature regulation of the blood product storage system, a base unit and at least one agitator unit with an upper connection side, a lower connection side, a movable compartment to receive the blood products and a drive for movement of the compartment, wherein the compartment is arranged between the upper connection side and the lower connection side, wherein the upper connection side of the agitator unit is selectively connectable to the temperature regulation unit or a further agitator unit, and wherein the lower connection side of the agitator unit is selectively connectable to the base unit or a further agitator unit.

The invention relates to an automatic valve for regulating a flow rate of liquid intended to circulate in a flexible tube, comprising: a cam system (23) mounted moveably on a base and rotationally around an axis of rotation, a bearing part (24) translationally mounted on the base, arranged to be translationally moved as a result of a rotational movement of the cam system (23), and comprising a compression portion (240), an abutment part (25) positioned opposite the compression portion (240), defining with the bearing part (24) a receiving space intended to receive a flexible tube (3), the translation of the bearing part (24) displacing the compression portion (240) along the direction of translation, in order to modify a dimension of the receiving space, a magnet and a magnetic sensor detecting the magnetic field generated by the magnet.

The invention relates to an automatic valve for regulating a flow rate of liquid intended to circulate in a flexible tube, comprising: a cam system (23) mounted moveably on a base and rotationally around an axis of rotation, a bearing part (24) translationally mounted on the base, arranged to be translationally moved as a result of a rotational movement of the cam system (23), and comprising a compression portion (240), an abutment part (25) positioned opposite the compression portion (240), defining with the bearing part (24) a receiving space intended to receive a flexible tube (3), the translation of the bearing part (24) displacing the compression portion (240) along the direction of translation, in order to modify a dimension of the receiving space, a magnet and a magnetic sensor detecting the magnetic field generated by the magnet.

The invention relates to a filtration unit for the leucocytapheresis of the blood or of a blood product. The filtration unit has an external pouch with at least one inlet orifice and with at least one outlet orifice. the external pouch contains a porous element interposed between the orifices. he porous element has at least one leucocytapheresis medium that works by adsorbing and/or by filtering out the leucocytes, and at least one nonwoven layer provided with bumps, each of the bumps having a perforation passing through it in the heightwise direction.

A biological component cassette includes a cassette main body having a flow path for the liquid in an interior of the cassette main body. The cassette main body is flexible and has a sheet-like shape. The biological component cassette includes a frame that is less flexible than the cassette main body. The frame includes an accommodation chamber in which the cassette main body is accommodated. A side portion of the frame forms at least part of the accommodation chamber. When the cassette main body is accommodated in the accommodation chamber, one surface of the cassette main body is covered by a bottom portion of the accommodation chamber, and another surface of the cassette main body is exposed to an external environment.

Efficient methods for capture and removal of fibrinogen from blood plasma fractions, especially cryoprecipitate, and Fraction II+III providing high yields of blood coagulation Factor VIII are disclosed. According to this disclosure, there is provided a method of separating plasma cryoprecipitate or Fraction II+III comprising a blood coagulation factor and fibrinogen into a first fraction comprising the blood coagulation factor and a second fraction containing the fibrinogen, the method comprising: (a) contacting he plasma cryoprecipitate with solid SiO.sub.2 or Al(OH).sub.3, thereby adsorbing the fibrinogen onto the solid SiO.sub.2 or Al(OH).sub.3; and (b) separating the fibrinogen adsorbed onto the solid SiO.sub.2 or Al(OH).sub.3 from the blood factor, thereby forming the first fraction and the second fraction.

Embodiments of the technology described herein are based upon the discoveries that neutrophil extracellular traps (NETs) provide a stimulus for thrombus formation and that NETs are present in stored blood products. Accordingly, some embodiments relate to methods of treating and preventing toxicity of NETs and thrombosis caused by NETs. Additional embodiments are directed towards methods of treating stored blood products to prevent transfusion-related injuries.

A blood donation system is provided that includes a plurality of collection containers (18, 20, 22, 24) interconnected by tubing (16, 28, 32, 34, 36, 38) and a leukocyte reduction filter (30). The system has a machine-readable identification code (48) associated therewith that is printed at repeated intervals on one of the tubings (16, 28, 32, 34, 36, 38), so as to define a plurality of discrete segments (44), each sized to contain a sample volume of blood or a blood product. After collection, heat seals (42) are formed on the tubing (16, 28, 32, 34, 36, 38) to capture in each segment (44) a volume of blood/blood product, such that a plurality of sample tubes are provided, each bearing the machine-readable identification code (48) and containing a volume of blood/blood product suitable for sample testing.

A blood treatment filter comprising a filter element, an inlet-side flexible container and an outlet-side flexible container, an inlet port, and a tubular outlet port, further comprises: an outlet-side frame sheet disposed between the filter element and the outlet-side flexible container; a first seal portion provided by sealing at least the filter element and the outlet-side frame sheet in a belt-shaped manner; and an annular second seal portion provided to surround the first seal portion, wherein on an outlet side of the filter element, a valley portion is formed at the first seal portion, the outlet port includes a protruding portion that protrudes to an inside of the container, and the protruding portion is provided with an opening at least a part of which overlaps with the first seal portion and which can communicate with a gap region formed by the valley portion.

A blood component collection cassette that can trap a substance where blood components coagulate by using a simple and economical configuration, and a manufacturing method of the blood component collection cassette are provided. A blood component collection cassette (28) includes a cassette main body (40) where a flow path (42) is formed and is configured to be mountable to a centrifugal separation device (14). The cassette main body (40) has a first sheet (40a) and a second sheet (40b) which are formed of a soft material. The flow path (42) is formed between the first sheet (40a) and the second sheet (40b). A filter member (60) for trapping a substance where blood components coagulate is arranged on the flow path (42) in the cassette main body (40).