A column for removal of a component from a fluid is disclosed. The column has a compartment with a cross sectional area. The compartment contains beads having a diameter. A ligand selected to bind to the component is coupled to the beads. The cross-sectional area and bead diameter are selected to maintain a flow velocity of the fluid within the compartment below a first threshold, thereby reducing leaching of the ligand into the fluid. Also described herein is an adsorbent comprising a ligand that is attached to a substrate by an amine bond, wherein the ligand is resistant to dissociation from the substrate.

Devices, systems, and methods for depleting fluids of immunoglobulins and leukocytes are disclosed.

A method for filling containers with fresh blood components, comprising the following steps of: a) providing a piece of equipment (1) defining a transit channel (3) having at least a first gap (3a) associated with a bag (5) or the like containing a fresh blood component, at least a second gap (3b) connected to a plurality of containers (6) to be filled, and at least a third gap (3c) connected to pumping means (12); b) isolating the first gap (3a) from the second gap (3b) and placing the latter in communication with the third gap (3c); c) suctioning the air contained in the containers (6) to be filled by means of the pumping means (12) so as to define a vacuum inside them; d) placing the first gap (3a) in communication with the second gap (3b), the containers (6) suctioning the contents of the bag (5) by effect of the vacuum defined inside them; and where the channel (3) has at least a fourth gap (3d) associated with an empty syringe (4) or the like, and by the fact that it comprises, after step d), the following steps of: e) isolating the first gap (3a) from the second gap (3b) and placing the first gap itself in communication with the fourth gap (3d); f) taking at least a part of the contents of the bag (5) by means of the syringe (4); g) isolating the fourth gap (3d) from the first gap (3a) and placing the fourth gap itself in communication with the second gap (3b); h) sending the contents taken with the syringe (4) into the containers (6).

The present disclosure provides apparatuses and systems for delivering a measureable absorbed-dose of a gaseous activating agent to a fluid including a biological liquid and/or cells. The apparatuses or systems include a gas-fluid contact device configured to controllably rotate or oscillate a control member having an interior surface in contact with the fluid and a control system configured to control rotation or oscillation of the contact member by the gas-fluid contact device. In some embodiments, the control system is further configured to control absorption of the gaseous activating agent by the fluid. The present disclosure also provides methods of treating a fluid including a biological liquid or cells with a gaseous activating agent to controllably activate the fluid.

The present invention relates to methods, combinations and pharmaceutical compositions for supplying a blood source from a donor source with a mis-matched blood type, or potentially a mis-matched blood type, to a recipient, using, inter alia, an effective amount of a nanoparticle comprising a) an inner core comprising a non-cellular material, and b) an outer surface comprising a cellular membrane derived from a red blood cell, the cellular membrane of the nanoparticle comprising a blood type antigen that exists on the red blood cell from the donor source, but is missing or potentially missing on red blood cells of the recipient.

Method and Apparatus for predicting the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags.

The disclosure provides for a container system and method for the cryopreservation and resuspension of a body fluid. The container system may include a cryopreservation container comprising the body fluid in a cryopreservation liquid, a resuspension container comprising a resuspension solution, a connection tube sterilely connecting the cryopreservation container and the resuspension container, and at least one shut-off element actively associated with the connection tube.

A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.

A centrifugal separation system includes a blood bag system and a centrifugal separation and transferring device. The blood bag system is equipped with a single clamp that is mounted over a second tube and a third tube. In a first blocking portion of a first insertion hole of the clamp, a portion thereof except for a portion connected with a first opening portion is closed by a main body. On the other hand, a second insertion hole of the clamp includes a tube detaching portion, that is connected with a second blocking portion and that enables the third tube to be detached from the main body.

A blood bag system includes one clamp mounted over a second tube and a third tube. In a first insertion hole of a main body of the clamp, a portion of a first blocking portion excluding a portion connected with a first opening portion is closed by the main body. The main body can be deformed from a first state to a second state. In the first state, the third tube having been moved into a second blocking portion of a second insertion hole is restrained by the second blocking portion. In the second state, the third tube can be moved from the second blocking portion to a position that is other than a second opening portion and in which a third flow path of the third tube is reopened.