The present invention is directed to a method and apparatus for delivering substances, e.g., therapeutic substances, into openings on or near a skin surface, such as hair follicles, pores and/or into sebaceous glands. This can be achieved by using an apparatus to direct a substance into the openings under pressure via one or more nozzles or slits. A portion of the sebum present in the hair follicle is optionally heated and/or removed, e.g. using low-pressure conduit located on the lower surface of the apparatus, before introducing the therapeutic substance.

The present invention is directed to a method and apparatus for delivering substances, e.g., therapeutic substances, into openings on or near a skin surface, such as hair follicles, pores and/or into sebaceous glands. This can be achieved by using an apparatus to direct a substance into the openings under pressure via one or more nozzles or slits. A portion of the sebum present in the hair follicle is optionally heated and/or removed, e.g. using low-pressure conduit located on the lower surface of the apparatus, before introducing the therapeutic substance.

A method for enhancing postoperative healing using a low pressure suction apparatus comprising obtaining a preferably both electrically powered and portable treatment apparatus capable of contacting, via a treatment head, a target area of a patient and introducing low-pressure suction, i.e. negative pressure flow, thereto, configuring the treatment apparatus so as to introduce predefined, advantageously, pulsating pressure variation to a suction opening arranged at the treatment head, and applying the suction opening of the treatment head on the target area before the surgery, i.e. during the preoperative period, and optionally after the surgery, while the treatment apparatus is on and providing the suction effect corresponding to the configuration.

A method for at least temporarily alleviating neuropathic pain comprising obtaining a preferably both electrically powered and portable treatment apparatus capable of contacting, via a treatment head, a target area of a patient and introducing low-pressure suction, i.e. negative pressure flow, thereto, configuring the treatment apparatus so as to introduce predefined, advantageously, pulsating pressure variation to a suction opening arranged at the treatment head, and applying the suction opening of the treatment head on the target area while the treatment apparatus is on and providing the suction effect corresponding to the configuration.

A method for at least temporarily alleviating neuropathic pain comprising obtaining a preferably both electrically powered and portable treatment apparatus capable of contacting, via a treatment head, a target area of a patient and introducing low-pressure suction, i.e. negative pressure flow, thereto, configuring the treatment apparatus so as to introduce predefined, advantageously, pulsating pressure variation to a suction opening arranged at the treatment head, and applying the suction opening of the treatment head on the target area while the treatment apparatus is on and providing the suction effect corresponding to the configuration.

One aspect of the invention provides a method for alleviating acne including: applying a therapeutic substance to an area of skin having follicles, said therapeutic substance comprising a plurality of metal nanoparticles within a carrier; using a device to impart mechanical energy to deliver some of said therapeutic substance into a plurality of follicles; removing the composition remaining on the skin surface while leaving the therapeutic substance in said follicles; and irradiating the skin to which the composition was applied with light energy effective to treat acne.

One aspect of the invention provides a method for alleviating acne including: applying a therapeutic substance to an area of skin having follicles, said therapeutic substance comprising a plurality of metal nanoparticles within a carrier; using a device to impart mechanical energy to deliver some of said therapeutic substance into a plurality of follicles; removing the composition remaining on the skin surface while leaving the therapeutic substance in said follicles; and irradiating the skin to which the composition was applied with light energy effective to treat acne.

Device for haemostatic control of a blood flow, comprising a suction cup which provides leaktight coverage and is able to surround and be applied tightly to a tissue area (2) that is to be treated, said tissue area (2) being the site of a haemorrhage or of a blood flow that is to be controlled, this suction cup (3) coming into contact with the periphery of the tissue area and delimiting an internal volume (8) which is connected in a leaktight manner, by a catheter or a similar connecting tube (7), to an external aspiration element that establishes a vacuum, so as to create an underpressure of defined value within this volume between the suction cup and the tissue area, the suction cup (3) having the general shape of a dome (4), of which the base (5) supports an inner bearing element (11) that can be arranged opposite the tissue area (2) under the suction cup (3). The invention lies in the inner bearing element being formed by a solid obturator (11) or an open grill (13).

Device for haemostatic control of a blood flow, comprising a suction cup which provides leaktight coverage and is able to surround and be applied tightly to a tissue area (2) that is to be treated, said tissue area (2) being the site of a haemorrhage or of a blood flow that is to be controlled, this suction cup (3) coming into contact with the periphery of the tissue area and delimiting an internal volume (8) which is connected in a leaktight manner, by a catheter or a similar connecting tube (7), to an external aspiration element that establishes a vacuum, so as to create an underpressure of defined value within this volume between the suction cup and the tissue area, the suction cup (3) having the general shape of a dome (4), of which the base (5) supports an inner bearing element (11) that can be arranged opposite the tissue area (2) under the suction cup (3). The invention lies in the inner bearing element being formed by a solid obturator (11) or an open grill (13).

A system and method for regenerating damaged or necrosed tissue. Negative or vacuum pressure is applied to a surface of the damaged tissue to stimulate the revascularization of the area and/or increased blood flow to the area, which encourages the regeneration of the damaged tissue. A negative pressure device is provided that is capable of providing a sequenced vacuum treatment regimen to damaged tissue.