A manifold for the circulation of fluids along predetermined circulation paths or circuits, for example, for extracorporeal dialysis machines. The manifold comprises a main body with a plurality of inner channels mutually connected to define the predetermined circulation paths, the predetermined circulation paths communicating with the exterior of the main body by way of at least one inlet and at least one outlet adapted to be connected to component parts and/or tubing of an extracorporeal dialysis machine, and dialysis machine equipped with the aforesaid manifold.

A valve island for a hydraulic assembly and a hydraulic assembly featuring a valve island. The valve island and the hydraulic assembly are used with a dialysis machine. The valve island has a main part in which at least one fluid flow duct is formed. The main part is produced by additive manufacturing or injection molding. The hydraulic assembly includes a support on which at least one valve island is arranged directly or indirectly.

The described technology may include processes to model a modality status in patients and/or patient populations. In one embodiment, a method may include a modality analysis. The method may include, via a processor of a computing device: determining a modality analysis model configured to determine a modality status of a patient, the modality status configured to indicate a probability of a transition from a first modality to a second modality, and generating the modality status via the modality analysis model using patient information associated with the patient. Other embodiments are described.

The described technology may include processes to model a modality status in patients and/or patient populations. In one embodiment, a method may include a modality analysis. The method may include, via a processor of a computing device: determining a modality analysis model configured to determine a modality status of a patient, the modality status configured to indicate a probability of a transition from a first modality to a second modality, and generating the modality status via the modality analysis model using patient information associated with the patient. Other embodiments are described.

Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

An apparatus for performing cerebral micro-dialysis to treat neurological disease of a patient's brain includes a catheter for implantation in or near the patient's brain, an implantable pump communicated with the catheter to transport cerebrospinal fluid (CSF) from the patient, which CSF contains diseased cells or biomolecules associated with the neurological disease, and an implantable separation device communicated with the pump wherein the diseased cells or biomolecules are removed, where the separation apparatus includes a dialysis membrane impregnated with an antibody, a reversible electrostatic filter, and/or a magnetic field effect fractionation chamber wherein a magnetically-tagged antibody scavenges and aids in the removal of circulating diseased cells or biomolecules from the CSF.

An apparatus for performing cerebral micro-dialysis to treat neurological disease of a patient's brain includes a catheter for implantation in or near the patient's brain, an implantable pump communicated with the catheter to transport cerebrospinal fluid (CSF) from the patient, which CSF contains diseased cells or biomolecules associated with the neurological disease, and an implantable separation device communicated with the pump wherein the diseased cells or biomolecules are removed, where the separation apparatus includes a dialysis membrane impregnated with an antibody, a reversible electrostatic filter, and/or a magnetic field effect fractionation chamber wherein a magnetically-tagged antibody scavenges and aids in the removal of circulating diseased cells or biomolecules from the CSF.

The present disclosure relates to a bag holder for receiving a first effluent bag, which serves for receiving effluent resulting from a blood treatment being performed by a blood treatment apparatus and includes at least one closable effluent outlet opening and at least one effluent inlet opening. The bag holder includes one or several rollers for rolling the bag holder and at least one of the following features: a holding device for holding the first effluent bag in the bag holder, a receptacle for receiving the first effluent bag or a section thereof, a pump section for conveying effluent out of first effluent bag being received in the bag holder, at least one effluent outlet line for guiding effluent towards the pump section and/or out of the first effluent bag and/or at least one basin line for guiding effluent into the first effluent bag and/or away from the bag holder.

The present disclosure relates to a control device or closed-loop control device, programmed to control or regulate a blood treatment apparatus during a treatment of a patient's blood carried out in a treatment session using an extracorporeal blood tubing set and the blood treatment apparatus while balancing liquid flows and conveying via different liquid pumps. The control device or closed-loop control device is further programmed to interrupt the balancing and/or the liquid flows at one or more predetermined interruption time points which lie within the duration of the treatment session.