A closed circulation system test apparatus independently sets the amount of a liquid such as a dialysate for a blood purification device, facilitates management of operations of multiple pumps, and is capable of evaluating performance for removing wastes in blood and lifespan performance of membranes. The closed circulation system test apparatus includes: a blood sending line for sending blood from the blood bag to the blood purification device via a blood pump; a blood returning line for sending blood exiting from the blood purification device to the blood bag via a resistance imparting means; a filtrate line for sending the filtrate exiting from a dialysate outlet of the blood purification device to the replacement fluid container via a filtrate pump; and a dialysate line for sending, via a dialysate pump, dialysate or replacement fluid from the replacement fluid container to a dialysate inlet of the blood purification device.

An extracorporeal blood treatment apparatus comprises: a blood treatment device (2) comprising a blood chamber (3) and a fluid chamber (4) separated from one another by a semipermeable membrane (5); an extracorporeal blood circuit (17) comprising a blood withdrawal line (6) connected to an inlet port (3a) of the blood chamber (3) and a blood return line (7) connected to an outlet port (3b) of the blood chamber (3); a blood pump (21) configured to be coupled to the blood withdrawal line (6); a hydraulic circuit (100) connectable to the fluid chamber (4), wherein the hydraulic circuit (100) comprises a fluid preparation device (9) connected to a water network (14) and configured to dilute concentrates in water to prepare a treatment fluid; a control unit (12) connected to the preparation device (9) and to the blood pump (21). The control unit (12) is configured to execute the following procedure: setting the hydraulic circuit (100) so that the fluid preparation device (9) bypasses the fluid chamber (4); controlling the fluid preparation device (9) to prepare the treatment fluid while bypassing the fluid chamber (4); and simultaneously controlling the blood pump (21) to perform pure ultrafiltration of a patient (P) connected to the extracorporeal blood circuit (17).

An extracorporeal blood treatment apparatus comprises: a blood treatment device (2) comprising a blood chamber (3) and a fluid chamber (4) separated from one another by a semipermeable membrane (5); an extracorporeal blood circuit (17) comprising a blood withdrawal line (6) connected to an inlet port (3a) of the blood chamber (3) and a blood return line (7) connected to an outlet port (3b) of the blood chamber (3); a blood pump (21) configured to be coupled to the blood withdrawal line (6); a hydraulic circuit (100) connectable to the fluid chamber (4), wherein the hydraulic circuit (100) comprises a fluid preparation device (9) connected to a water network (14) and configured to dilute concentrates in water to prepare a treatment fluid; a control unit (12) connected to the preparation device (9) and to the blood pump (21). The control unit (12) is configured to execute the following procedure: setting the hydraulic circuit (100) so that the fluid preparation device (9) bypasses the fluid chamber (4); controlling the fluid preparation device (9) to prepare the treatment fluid while bypassing the fluid chamber (4); and simultaneously controlling the blood pump (21) to perform pure ultrafiltration of a patient (P) connected to the extracorporeal blood circuit (17).

An embodiment provides a method for treating a body fluid of a patient with morbid obesity, including: removing the body fluid from a patient; applying a treatment to the body fluid, wherein the treatment comprises an antibody that joins with a morbid obesity targeted antigen (TA) in the body fluid to form an antibody-TA complex, wherein the antibody comprises a tag sensitive to an illumination; removing the antibody-TA complex from the body fluid using an illumination source; and returning the body fluid to the patient. Other aspects are described and claimed.

A method and system is provided that measures plasma protein levels of whole blood while a plasma donor is connected to an apheresis machine. A refractometer associated with the apheresis machine is capable of receiving a portion of a disposable tubing set including an integrated cuvette and prism. The integrated cuvette of the disposable tubing set can be inserted into a receiving space of the refractometer associated with the apheresis machine such that the light source and the sensor are oriented relative to the prism and a sensing surface of the integrated cuvette in a precise alignment. Calibration of the refractometer is made using anticoagulant pumped through the disposable tubing set including the integrated cuvette and prism. Based on a light intensity associated with this calibration, whole blood is then measured to determine plasma protein levels and donor eligibility.

The present disclosure provides apparatuses and systems for delivering a measureable absorbed-dose of a gaseous activating agent to a fluid including a biological liquid and/or cells. The apparatuses or systems include a gas-fluid contact device configured to controllably rotate or oscillate a control member having an interior surface in contact with the fluid and a control system configured to control rotation or oscillation of the contact member by the gas-fluid contact device. In some embodiments, the control system is further configured to control absorption of the gaseous activating agent by the fluid. The present disclosure also provides methods of treating a fluid including a biological liquid or cells with a gaseous activating agent to controllably activate the fluid.

A system for filling multiple sterile containers includes a filter with an inlet port and multiple outlet ports, the outlet ports being pre-attached to sterile containers by respective filling lines of each container. Each container has an interior and each of the respective filling lines are connected to a respective container interior. The respective filling lines are sealed to the outlet ports and the containers such that the container interiors are isolated from an external environment except the inlet port, via the filter, forming a combined interior volume which is sterile. A container that is connectable to an outlet port the system has a bladder, a first tube and a second tube connected to the bladder, and a sterilizing filter. The container, the first tube and the second tube, and the sterilizing filter are sterile before water is flowed through the sterilizing filter into the bladder.

A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.

A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.

A filter and a device including the filter may include a filter and a plurality of pores arranged two-dimensionally on the filter. The plurality of pores may include a plurality of first pores having a longer structure in a certain direction and a plurality of second pores having a longer structure in a direction different from that of the first pore. The first and second pores may have a two-dimensional arrangement in order to suppress or prevent the occurrence of cracks in the filter due to stress.