A blood treatment machine includes a patient comfort feedback mechanism configured to be adjusted by a patient to indicate comfort levels of the patient. The machine is configured to adjust one or more treatment parameters based on the patient feedback.

An irradiation device includes a fluid treatment chamber having first and second opposing sides configured to receive a biological fluid container therebetween, and at least one light source disposed adjacent at least one of the first and second sides of the fluid treatment chamber. The at least one light source includes a light guide having a front planar surface that defines in part the at least one of the first and second sides of the fluid treatment chamber, and at least one light emitting diode (LED) disposed at an edge of the light guide outside the fluid treatment chamber and configured to direct light into the light guide. The light guide has a back surface opposite the front planar surface, the back surface with one or more reflectors that depend into the light guide in the direction of the front surface.

Dialysis systems and methods for operating dialysis machines (e.g., peritoneal dialysis machines) for conducting dialysis treatments are disclosed. The dialysis system may include a dialysis machine for transferring dialysate to a patient from a dialysate source. The dialysate may flow from the dialysate source through a cartridge or cassette (e.g., a disposable cartridge or cassette) positionable within the dialysis machine. The cassette includes a fluid flow channel. The dialysis machine includes a heating chamber for in-line heating of the dialysate in the fluid flow channel. The fluid flow channel is arranged and configured to provide turbulent flow of the dialysate through the fluid flow channel to provide increased heat transfer from the heating chamber to the dialysate.

An external end device has a casing (4), a fitting (15) housed in the casing (4) and having at least one distal part (16) which engages a catheter (3), and two proximal tracts (17, 17), in which a pair of curved pipes (18, 18) are inserted with a distal end (180) thereof. The curved pipes (18, 18) have a proximal end (181), in which a pair of nozzles (190, 190) are inserted. Inside each nozzle (190) there is a cap (20) suitable for hermetically sealing the nozzle (190). A piercing and connecting conduit (24) is adapted to reversibly pierce the cap (20) and to connect the pair of nozzles (190, 190) to the flow lines of the treatment equipment. Also disclosed is a method of connecting the external terminal device to flow lines of a machine.

Systems and methods for performing apheresis procedures, including photopheresis, are disclosed. The systems and methods utilize a disposable fluid circuit that can be converted from a double needle configuration to a single needle configuration and from a single needle configuration to a double needle configuration. A controller directs the action of system pumps to clear potentially stagnant blood residing in the fluid circuit, tracks system parameters and status before and after conversion, and verifies that the procedure may proceed in its new configuration.

Systems and methods are provided for separating platelets from blood. Prior to blood separation, a volume of blood to be processed, a volume of platelets to be collected, and/or a time required to complete blood draw from a source during a blood separation procedure is determined. Based on that determination, a procedure setpoint is calculated from the completion of the blood draw. Blood is subsequently drawn from a source into a separator in which the blood is separated into a mononuclear cell-containing fraction and a platelet-containing fraction. At least a portion of the platelet-containing fraction is conveyed from the separator, while the volume of the mononuclear cell-containing fraction in the separator increases. The mononuclear cell-containing fraction is conveyed to the source from the separator at the procedure setpoint. The blood draw and separation are then ended.

An integrated catheter assembly includes a housing member, an outer lumen member extending from the housing member, and a needle member slidably or movably coupled to the housing member, wherein the needle member can be extended beyond a first port of the outer lumen member in a first position and concealed in the outer lumen member in a second position. The outer lumen member has a side port between its first and second ports such that when the needle is extended in the first position and inserted into an arteriovenous fistula, blood from the arteriovenous fistula flashes into the needle member, is diverted through a relief port of the needle member out the side port of the outer lumen member for delivery to a dialysis machine. The assembly further includes an inner lumen member that is disposable through the housing member to extend out from the same the outer lumen member to provide dialyzed blood from the machine. The assembly therefore receives and delivers blood through a single injection site.

Microbubbles detached from a blood circuit and a blood purification unit are discharged with the use of a backflow generated at the instant that a roller of a blood pump releases a squeezable tube. In a normal rotation step, a region filled with a priming solution after a priming step is closed by a closing unit, and a rotor of a blood pump is rotated normally until a roller of the blood pump releases a squeezable tube to generate a backflow. After the backflow is generated at the release of the squeezable tube by the roller of the blood pump, bubbles are moved by reversely rotating the rotor while disabling the closing by the closing unit. Thus, the bubbles are discharged through a discharge unit.

A dialysis system may include a blood circuit, a cassette, a subsystem having a processor, a sensor, and a blood pumping mechanism, a housing in which the subsystem is arranged, a movable support arranged in the housing and configured to hold the sensor and/or the blood pumping mechanism of the subsystem, a cassette holder configured to removably receive the cassette, and a loading system. The loading system may be configured to move the movable support, e.g. by an axial movement, to a first position and to a second position relatively to the housing while the cassette holder is fixedly arranged in the housing. The loading system may have an electric motor controlled by the processor, a drive assembly coupled to the electric motor, and a guiding assembly configured to cooperate with the drive assembly.

An adapter set that is attached to artery-side and vein-side shunt connectors-that are provided on a blood circuit. The adapter set includes: an artery-side adapter that has one end thereof connected to the artery-side shunt connector, has the other end thereof connected to a drainage port that is provided on the outside of the blood circuit, and thereby connects the artery-side shunt connector and the drainage port fluid tight; and a vein-side adapter that has one end thereof connected to the vein-side shunt connector, has the other end thereof connected to a supply port that is provided on the outside of the blood circuit, and thereby connects the vein-side shunt connector and the supply port fluid tight. The structure of the other end of the artery-side adapter and the structure of the other end of the vein-side adapter are different.