The invention provides an integrated system and method for fabricating, regenerating, and maintaining synthetic living wood tissue constructs. The platform utilizes a formulation subsystem that prepares plant-derived precursor cells, lineage-directing Exomix signaling vesicles, and a supportive cellulose-based hydrogel into a printable bio-ink. An additive biofabrication subsystem generates structured constructs containing organized cambial, xylem, and phloem domains, microfluidic vascular channels, and embedded niche reservoirs. A maintenance and repair subsystem preserves tissue viability, delivers targeted regeneration cues, and supports long-term integration with damaged or aging wood substrates. Environmental control modules regulate electrical, mechanical, thermal, and biochemical parameters to guide differentiation and maturation. The invention enables sustainable production of regenerative wood materials with enhanced strength, decay resistance, and customizable properties, addressing limitations of natural wood through controlled biomanufacturing and restoration workflows.

The invention provides an integrated system and method for fabricating, regenerating, and maintaining synthetic living wood tissue constructs. The platform utilizes a formulation subsystem that prepares plant-derived precursor cells, lineage-directing Exomix signaling vesicles, and a supportive cellulose-based hydrogel into a printable bio-ink. An additive biofabrication subsystem generates structured constructs containing organized cambial, xylem, and phloem domains, microfluidic vascular channels, and embedded niche reservoirs. A maintenance and repair subsystem preserves tissue viability, delivers targeted regeneration cues, and supports long-term integration with damaged or aging wood substrates. Environmental control modules regulate electrical, mechanical, thermal, and biochemical parameters to guide differentiation and maturation. The invention enables sustainable production of regenerative wood materials with enhanced strength, decay resistance, and customizable properties, addressing limitations of natural wood through controlled biomanufacturing and restoration workflows.