A prepackaged injectable pharmaceutical composition includes a sealed outer package made of a material having a low oxygen transmission rate and an inner package disposed within the sealed outer package. The inner package is configured to provide an indication that the inner package has been opened after being closed. A prefilled syringe is disposed within the inner package. The syringe includes a barrel comprising a polymeric material and a dose of the injectable pharmaceutical composition.

A tray (100) for accommodating a coiled medical device, such as a catheter assembly (700), includes a first compartment (101), a second compartment (102), and a third compartment (103). The catheter assembly (700) and devices associated with a catheterization procedure, such as syringes (701,702) containing sterile water and lubricating jelly and a specimen container (703) can be disposed within the tray. Printed instructions (1001) can be included with the tray (100). One or more layers of wrap material (2200) can be folded about the tray (100) to enclose the tray (100) and other items, such as an additional layer of wrap material (2701), packaged liquid hand sanitizer (2401), and packaged gloves (2402). When a health care services provider (3101) unfolds the wrap material, the same can be used to create a sterile field beneath a patient (3201).

Packages comprising a film surrounding the medical device are described and including a tear-enabling feature and a gripping feature enabling a user to use a finger, a thumb or an end of a tool to apply a sufficient tearing force to cause the tear-enabling feature to tear and move the first end of the package away from the second end of the package using only one hand and to expose the medical device to be accessed for use. Also described are methods of packaging a medical device.

A medical device packaging comprises a container having an opening. A medical device is disposed within the container. The medical device includes an adhesive contact face facing the opening. A first cover is disposed over the opening in the container to close the container. A second cover is disposed over the adhesive contact face of the medical device. The first and second covers are connected such that removal of the first cover from the container causes detachment of the second cover from the medical device.

A liquid formulation of an ophthalmic drug in a pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer.

A cartridge system comprising a carrier reel, distal and proximal take-up reels, a main guide post adapted to engage the main guide support, a first strip guide post, a second strip guide post, and a packaging strip. The packaging strip comprises first and second strip portions detachably secured to define a plurality of item chambers. At least one item is enclosed within each of the item chambers. The carrier reel is adapted to store the packaging strip. The distal take-up reel is operatively connected to the first strip portion. The proximal take-up reel is operatively connected to the second strip portion. Rotation of the distal and proximal take-up reels unwinds the packaging strip from the main wheel such that the first strip portion is wound onto the distal take-up reel, and the second strip portion is wound onto the proximal take-up reel.

A holding structure for concurrently holding a plurality of containers for substances for pharmaceutical, medical or cosmetic applications includes a plurality of receptacles for receiving the containers therein at least in sections. The receptacles each have an open upper end for inserting the containers into the receptacles and a bottom end having a holding portion for limiting an axial movement of the containers in the receptacles. Guide portions are provided for guiding the containers as they are inserted into the receptacles. The guide portions are formed as guiding ribs extending in the longitudinal direction of the receptacles. Lead-in bevels are formed at upper ends of the guiding ribs which are inclined relative to the guiding ribs.

A packaging line implemented for packaging a pre-filled syringe is disclosed having a NSD mounting station, a PFS delivery arrangement adapted to automatically deliver a pre-filled syringe to the NSD mounting station, and a NSD delivery arrangement adapted to automatically deliver a needle safety device to the NSD mounting station. The NSD mounting station is arranged to automatically assemble the needle safety device to the pre-filled syringe. A NSD visual inspection station is adapted to automatically identify a pre-filled syringe with an unfit needle safety device and to automatically eliminate the identified pre-filled syringe from the packaging line. A re-insertion station is further provided to receive a pre-filled syringe with a needle safety device and to automatically feed the received pre-filled syringe, preferably from a rejected secondary packaging, back into the packaging line, after the NSD mounting station and before the NSD visual inspection station.

Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3β, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.

A dispensing system for items comprises a main housing and a cartridge assembly. The cartridge assembly comprises a carrier reel, distal and proximal take-up reels, and a packaging strip comprising first and second strip portions detachably secured to define a plurality of item chambers, where at least one item is enclosed within each of the item chambers. The main housing assembly defines a dispensing opening and comprises a drive system. The drive system is operatively connected to the proximal and distal take-up reels. Operation of the drive system rotates the distal and proximal take-up reels such that operation of the drive system rotates the distal and proximal take-up reels such that the packaging strip is unwound from the main wheel, the first strip portion is wound onto the distal take-up reel, the second strip portion is wound onto the proximal take-up reel, and the items are dispensed through the dispensing opening.