A method for the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also discloses.

A system for a medical system includes a position sensing unit to sense a displacement of a medical device from a medically operational point on a subject, and a signal processing circuit to output, based on the sensed displacement, a signal to disable an alert system when the medical device is for sensing a physiological parameter of a subject during a medical procedure and the displacement is greater than a first threshold value, or to output a signal to enable the alert system when the medical device is for delivering treatment to the subject and the displacement is greater than a second threshold value.

A medical gas blending system includes a first syringe configured to be connectable to a supply of a first gas, and a second syringe configured to be connectable to a supply of a second gas. A three-way valve is provided between the first syringe and the second syringe. The three-way valve is operable in a first configuration to selectively isolate the first syringe from the second syringe, in a second configuration to allow communication between the first syringe and the second syringe, so that the first gas present in the first syringe and the second gas present in the second syringe may be selectively blended in the first syringe and/or the second syringe to form a blended gas mixture, and in a third configuration so that the blended gas mixture may be transferred from the first syringe and/or the second syringe to an external syringe connectable to the three-way valve.

Self-regulating electrolytic gas generator and implant system including the same. In one embodiment, the electrolytic gas generator is a water electrolyzer and includes a polymer electrolyte membrane with an anode on one side and a cathode on the other side. Anode and cathode seals surround the peripheries of the anode and cathode and include inlets for water and outlets for oxygen and hydrogen, respectively. A cathode current collector is placed in contact with the cathode, and an anode current collector, which may be an elastic, electrically-conductive diaphragm, is positioned proximate to the anode. The anode current collector is reversibly deformable between a first state in which it is in direct physical and electrical contact with the anode and a second state in which it distends, due to gas pressure generated at the anode, so that it is not in physical or electrical contact with the anode, causing electrolysis to cease.

Catheters for infusion of cardiovascular fluids into blood are disclosed. The cardiovascular fluid may, for example, comprise water highly supersaturated with a gas such as oxygen. Each catheter comprises one or more capillary tubings (or capillaries) through which a cardiovascular fluid flows. The distal end of each capillary is mounted (e.g., potted) preferably flush with an external surface of a catheter sidewall, while the proximal end of each capillary is in fluid communication with a cardiovascular fluid flowing through the lumen of the catheter. The combination of the catheter shape and the orientation of the distal end of each capillary relative to the longitudinal axis of the catheter provides control over the mixing pattern of the cardiovascular fluid with blood flowing within a vascular space such as an aorta.

A method for delivering nitric oxide therapy to a subject can include administering a composition including a nitric-oxide releasing agent and silica to the subject and releasing a therapeutic amount of nitric oxide from the composition.

The disclosure sets forth various exemplary embodiments of systems, methods, and/or medical apparatuses including but not limited to: a sheath; and a balloon disposed at a working distal end of the sheath. According to one example embodiment the medical device can include where the sheath can include woven wire reinforcing axial and longitudinal strength, side holes, a one direction distal valve, and can include an inflator. According to one example embodiment the medical device can include where the sheath can include a narrow cross-section of, e.g., 7-8 Fr and balloon of length of, e.g., 12 cm.

Electrolytic gas generator and multi-functional current collector for use in same. In one embodiment, the current collector is constructed both to conduct current from an electrode to a conductive lead and to conduct gas generated at the electrode to external tubing. Accordingly, the current collector may be formed by bonding together a top metal plate and a bottom metal plate of similar profiles, each of which may be shaped to include a main portion and a lateral extension. The bottom metal plate may have central through hole in the main portion for receiving gas from the anode. The top metal plate may have a recess on its bottom surface. The recess may have a first end aligned with the through hole on the bottom metal plate and may have a second end at the end of the lateral extension. A lead and tubing may be attached to the lateral extension.

System for gas treatment of cellular implants. The system enhances the viability and function of cellular implants, particularly those with high cellular density, for use in human or veterinary medicine. The system utilizes a miniaturized electrochemical gas generator subsystem that continuously supplies oxygen and/or hydrogen to cells within an implantable and immunoisolated cell containment subsystem to facilitate cell viability and function at high cellular density while minimizing overall implant size. The cell containment subsystem is equipped with features to allow gas delivery through porous tubing or gas-only permeable internal gas compartments within the implantable cell containment subsystem. Furthermore, the gas generator subsystem includes components that allow access to water for electrolysis while implanted, thereby promoting long-term implantability of the gas generator subsystem. An application of the system is a pancreatic islet (or pancreatic islet analogue) implant for treatment of Type 1 diabetes (T1D) that would be considered a bio-artificial pancreas.

A treatment method to cure diseases within a patient by administering intravenous oxygen-ozone mixture (Oxygen Ozone Regenerative Therapies, OORT). Specifically, the present application discloses a method of administering an intravenous oxygen-ozone mixture (Oxygen Ozone Regenerative Therapies, OORT). The method comprises the steps of: (A) providing a syringe, an infusion device and a tourniquet; (B) identifying an accessible peripheral vein on an upper extremity of a user; (C) preparing a volumetric dosage of an oxygen-ozone mixture (Oxygen Ozone Regenerative Therapies, OORT) with the syringe; (D) applying the tourniquet to a cannulation area on the upper extremity and inserting the infusion device into the accessible peripheral vein; and (E) transferring the volumetric dosage of the oxygen-ozone mixture (Oxygen Ozone Regenerative Therapies, OORT) from the syringe through the infusion device and into the accessible peripheral vein at a specified infusion rate by releasing the tourniquet from the cannulation area after a witnessed flash of blood