Engineered nanoscale multicomponent particles are introduced and are called “quants.” Methods and apparatuses for producing such multicomponent nanoparticles are provided. A single quant can be manufactured to contain a variety of different internal component molecules. Likewise, a plurality of such quants may be manufactured wherein the plurality of quants are suspended in an aqueous solution. Typically, quants are produced in quantity and concentration adequate to support human scale therapeutics. In some embodiments, millions or billions of quants are suspended in a volume of aqueous solution for delivery to a patient. When manufactured to the same specification, the plurality of quants are uniform in size, uniform in chemical composition, and therefore uniform in functionality. Functional uniformity is an essential aspect of quants, manifested in design and production. By controlling the variables of manufacture, such as particle size and composition, and by redefining a drug dose as the measured number of quants delivered (as opposed to measuring a drug dose by the mass of its active ingredient), the performance of these nanoparticle-based drugs introduce significant efficiencies and much higher value products to the expanding therapeutics market.

A method for improved controlling of a thermic infusion system having a one tubal segment and a thermal element to heat an infusion fluid carried within the tubal segment, and having at least one sensor positioned within the thermic infusion system comprising regulating energy provided to the sensor for a first period of time to sense a self-heating effect of the at least one sensor due to a dry tube; responsive to detecting a dry tube, preventing energizing the thermal element; responsive to detecting a non-dry tube, regulating energy provided to the sensor for a second period of time to sense a temperature of an infusion fluid carried within the at least one tubal segment.

A method for improved controlling of a thermic infusion system having a one tubal segment and a thermal element to heat an infusion fluid carried within the tubal segment, and having at least one sensor positioned within the thermic infusion system comprising regulating energy provided to the sensor for a first period of time to sense a self-heating effect of the at least one sensor due to a dry tube; responsive to detecting a dry tube, preventing energizing the thermal element; responsive to detecting a non-dry tube, regulating energy provided to the sensor for a second period of time to sense a temperature of an infusion fluid carried within the at least one tubal segment.

In some embodiments, a medical fluid connector is configured to receive an emitter of therapeutic agents to be emitted into a fluid pathway within the connector, the medical fluid connector comprising a proximal female end, an intermediate region, a distal male end, and a fluid pathway extending from the proximal female end, through the intermediate region, to the distal male end. A retaining structure is positioned within the intermediate region. The retaining structure is configured to securely receive an emitter of one or more therapeutic agents in a position and orientation where the fluid pathway is configured to convey fluid moving longitudinally through the fluid pathway directly into a proximal region of the emitter, around one or more lateral surfaces of the emitter, and toward the distal male end.

Provided is a warming device which can efficiently warm a blood product and inhibit a liquid in a warming flow path from exceeding an upper limit temperature thereof when liquid delivery of the blood product is stopped. The warming device includes the warming flow path in which the blood product flows and a heat plate which is in contact with the warming flow path to supply heat to the warming flow path. On the heat plate, a heater in a predetermined pattern corresponding to the warming flow path is disposed. The heater is disposed such that an amount of heat generation toward the warming flow path decreases in stages from an upstream side toward a downstream side in the warming flow path and that a decrease rate of the amount of heat generation at each of the stages decreases from the upstream side toward the downstream side.

Provided is a warming device which can efficiently warm a blood product and inhibit a liquid in a warming flow path from exceeding an upper limit temperature thereof when liquid delivery of the blood product is stopped. The warming device includes the warming flow path in which the blood product flows and a heat plate which is in contact with the warming flow path to supply heat to the warming flow path. On the heat plate, a heater in a predetermined pattern corresponding to the warming flow path is disposed. The heater is disposed such that an amount of heat generation toward the warming flow path decreases in stages from an upstream side toward a downstream side in the warming flow path and that a decrease rate of the amount of heat generation at each of the stages decreases from the upstream side toward the downstream side.

An apparatus including tubing sets, a modular constraint assembly, and methods of use are described for deliver a therapeutic medication to a patient, the apparatus can have a controller and a sensor. The controller is configured to receive data from the sensor, and to start and stop delivery of the therapeutic medication to the patient in response to data received from the sensor. In addition, apparatus, systems and methods are disclosed, which are configured to deliver a therapeutic medication to a patient. The apparatus, system and methods use a reservoir, a patient interface, a tubing set, a modular constraint assembly connected to the tubing sets, and a fluid pump, and the components are configured to provide a calibrated flow rate based upon specific characteristics of the therapeutic medications passing through and internal lumen of the tubing set.

Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

A fill adapter system for an infusion pump assembly. The system includes a reusable fill adapter base, the base including a volume control mechanism to adjust an available fill volume of a reservoir of the infusion pump assembly and a pump mechanism configured to pump air into a fluid vial. The system also includes a vial adapter assembly including a first needle configured to penetrate a septum of the fluid vial for fluidly coupling the pump mechanism to the fluid vial and a second needle having a first end configured to penetrate the septum of the fluid vial and a second end configured to penetrate a septum of the reservoir of the infusion pump assembly to allow transfer of fluid from the fluid vial to the reservoir of the infusion pump assembly in response to air being pumped into the fluid vial and a needle carriage adapted to carry the first needle and the second needle, wherein the needle carriage slidably attached to the interior of the vial adapter assembly, wherein the needle carriage adapted to slide from a vial end of the vial adapter to a receptacle end of the vial adapter.