Air-in-line sensor systems and methods of using same are provided. The system includes an adapter (60) including first and second cylindrical portions defining a fluid flow channel, the first cylindrical portion comprising two adjacent wedge-shaped protrusions (68). Each wedge-shaped protrusion is infrared transmittive and defines an outer surface and an inner surface. The system further includes a tube and an infrared reflective sensor having an infrared light emitter (42,52) and an infrared light detector (44,54). The infrared light emitter and the infrared light detector are positioned at or near an adapter so that an infrared light can be transmitted to the adapter and at least a portion of the infrared light reflected off the adapter can be detected by the infrared light detector.

An air bubble sensor has a holder at which at least one ultrasonic sensor is arranged to detect air bubbles and/or gas bubbles in a flowing liquid, wherein a flow passage which has connection pieces is integrated into the holder.

A drug delivery device adapted to receive a drug-filled cartridge (10), comprising dose setting means allowing a user to set a desired dose of drug to be expelled, an electronic controller (70,270) adapted to control a motor (51) to move a drive member to thereby expel an amount of drug from a received cartridge corresponding to a set dose, and means for estimating the amount of free air in a loaded cartridge. The controller is adapted to detect an error state if the estimated amount of free air in the cartridge is larger than or equals a given percentage of the amount of drug corresponding to a set dose.

A drug delivery device adapted to receive a drug-filled cartridge (10), comprising dose setting means allowing a user to set a desired dose of drug to be expelled, an electronic controller (70,270) adapted to control a motor (51) to move a drive member to thereby expel an amount of drug from a received cartridge corresponding to a set dose, and means for estimating the amount of free air in a loaded cartridge. The controller is adapted to detect an error state if the estimated amount of free air in the cartridge is larger than or equals a given percentage of the amount of drug corresponding to a set dose.

To provide an agent for hypodermic injection that is unlikely to cause inflammation and to provide an injector containing the agent for hypodermic injection.

There is provided a method for producing an agent for hypodermic injection, wherein the agent includes a hydrogel containing sintered hydroxyapatite particles, and the production method includes a deaeration step for removing air contained in the agent.

To provide an agent for hypodermic injection that is unlikely to cause inflammation and to provide an injector containing the agent for hypodermic injection.

There is provided a method for producing an agent for hypodermic injection, wherein the agent includes a hydrogel containing sintered hydroxyapatite particles, and the production method includes a deaeration step for removing air contained in the agent.

A system and method are disclosed in the field of preparing a catheter for use in a patient, in particular a catheter of an intravascular blood pump, more specifically for properly purging and de-airing the catheter. The catheter comprises an elongate tubular portion and a connected device. The elongate tubular portion is configured to be inserted into a patient's blood vessel and defines a lumen. The connected device is connected to the elongate tubular portion and has a cavity, which may accommodate a drive unit of the blood pump, and which is in fluid communication with the lumen of the elongate tubular portion. In order to securely de-air the system, a sensor, such as an accelerometer, for detecting an orientation of the connected device is provided, and a user may be guided to correct the orientation of the connected device for proper purging.

A system and method are disclosed in the field of preparing a catheter for use in a patient, in particular a catheter of an intravascular blood pump, more specifically for properly purging and de-airing the catheter. The catheter comprises an elongate tubular portion and a connected device. The elongate tubular portion is configured to be inserted into a patient's blood vessel and defines a lumen. The connected device is connected to the elongate tubular portion and has a cavity, which may accommodate a drive unit of the blood pump, and which is in fluid communication with the lumen of the elongate tubular portion. In order to securely de-air the system, a sensor, such as an accelerometer, for detecting an orientation of the connected device is provided, and a user may be guided to correct the orientation of the connected device for proper purging.

A single plate capacitive bubble detection sensor. The detector may employ a single active plate. A parasitic capacitance of the active plate relative to the environment may be monitored without reference to any particular ground source. In this regard, highly sensitive measurements may be made of a tube disposed adjacent to the active plate to detect, for example, the presence of air, liquid, or a change between liquid and air in the tube.

An apparatus having an outer wall that encompasses an interior chamber that holds a predetermined volume of fluid and gas where the gas rises to one end of the interior chamber and the fluid flows to the other end of the interior chamber. The apparatus also has an inlet port that allows for fluid to ingress into the interior chamber and an outlet port that allows for fluid to egress out of the interior chamber.