Disclosed herein are structures for ensuring that the reservoir of drug delivery device is free from any residual air before the device is filled with a liquid drug and put into use. The structures described herein are designed to prevent air from entering the reservoir during the pendency of a shelf life of the drug delivery device and/or to remove any residual air that has entered the reservoir of the drug delivery device prior to it being filled with the liquid drug.

This invention relates to the preservation of vascularized tissues and organs by freezing or by vitrification; to organ and tissue cryopreservation or banking; and to tissue and organ perfusion with cryoprotective agents (also known as cryoprotectants).

This invention relates to the preservation of vascularized tissues and organs by freezing or by vitrification; to organ and tissue cryopreservation or banking; and to tissue and organ perfusion with cryoprotective agents (also known as cryoprotectants).

A fluid sensing apparatus and method for detecting pressure and the presence of bubbles within a fluid tube. The fluid sensor comprises a housing configured to receive a portion of the tube and to house the pressure sensor and the ultrasonic transmitter. The pressure sensor is positioned adjacent the tube and is configured to receive a pressure sensor signal, which correlates to a detected pressure differential within the tube. A controller transmits a drive signal to the ultrasonic transmitter, which emits ultrasonic waves through a portion of the tube and to the pressure sensor. The pressure sensor receives both the ultrasonic waves and a pressure sensor signal, and subsequently transmits an output signal to the controller. In the presence of a pressure differential or a bubble within the tube, the output signal will exhibit a DC shift or a distortion of its signal characteristics, respectively.

Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.

Described herein is a delivery device (100) for delivering a drug and comprising a housing (102) having an outlet (104) and a cartridge compartment (108) to receive a cartridge (112) filled with an active pharmaceutical formulation in solid form, a transporting mechanism (132) to transport a predetermined amount of the formulation to a flushing position (134), a pumping mechanism (146) connectable to a solvent reservoir (147) and to deliver solvent from the solvent reservoir (147) towards the outlet (104), a jetting piston (154) to enter the flushing position (134) and to flush the predetermined amount of the formulation from the flushing position (134) with a predetermined amount of the solvent towards the outlet (104), and a controller (114) to control operation of at least one of the transporting mechanism (132), the pumping mechanism (146), and the jetting piston (154).

A non-surgical method of delivering a liquid radioactive solution from a source to a recipient comprising the steps of: determining a desired recipient level of radioactivity and recipient volume of the radioactive solution to be delivered to the recipient, providing a first valve having a waste position and a recipient position, providing a bolus conduit, a waste conduit and a recipient conduit, each conduit having a valve end being connected to said first valve, so that the first valve can establish a waste flow path in the waste position and a recipient flow path in the recipient position, the recipient flow path being different from said waste flow path, the bolus conduit comprising a measuring section and an internal volume, the internal volume being approximately equal to the desired recipient volume of the radioactive solution to be delivered to the recipient, arranging said first valve in the waste position, transporting a first amount of said radioactive solution through said waste flow path, the first amount of said radioactive solution having an initial level of radioactivity that is at least approximately equal to or higher than the desired recipient level of radioactivity and an initial volume that is larger than the internal volume of said bolus conduit, providing a radiation detector, the radiation detector being operable to measure a level of radioactivity of the radioactive solution in said measuring section, measuring a reference level of radioactivity of said radioactive solution present in said measuring section, wherein when the reference level of radioactivity is approximately equal to an injection level of radioactivity, the method further comprises the steps of: arranging the first valve in the recipient position, and transporting the radioactive solution present in the bolus conduit through the recipient flow path.

Provided is a contrast medium injection system that allows a connector of a tube connected to a patient to be reliably locked and easily unlocked with a small force and kept clean in normal use.

The system includes a detachably attachable injection line kit, at least one fluid injection flow path and a first connector provided on a downstream end of the flow path. The kit includes at least one patient connection flow path and a second connector that is provided on an upstream end of the patient connection flow path and detachably attachable to and engageable with the first connector. The contrast medium injection system body has a first set position where the kit is set and a second set position where the first and second connectors are engaged more deeply than in the first set position.

Apparatuses for priming a drip chamber of an infusion tube seta are described. A priming apparatus may be incorporated into a cavity of a body, such as a drip chamber cap, that is attached to or integrally formed with the inlet side of drip chamber. The priming apparatus includes a closure mechanism at least a portion of which is accommodated in a cavity in the body. The cavity is part of an outflow or vent passage through the body (e.g., the drip chamber cap) and the closure mechanism is operable, e.g., responsive to user force, to selectively open the outflow passage, thereby unsealing the vent cavity to ambient air and allowing air to be purged from the fluid system during priming of the drip chamber. When the closure mechanism is an closed position, the outflow passage and vent cavity as sealed from ambient air, preventing any air from passing into the fluid system through the cap.

Devices, systems, and methods are provided herein for delivering medication (e.g., insulin) via a wearable pump having a patch-style form factor for adhesion to a user’s body. The reusable pump may be coupled to a disposable cap housing a microdosing system for delivering precise, repeatable doses of medication to a cannula configured to deliver medication to a target infusion area beneath the user’s outer skin layer. The system further may include an applicator for inserting the cannula into the user’s skin and/or applying an adhesive pad to the skin.