A system for cooling the brain of a human subject, includes a cooling subsystem which inputs a flow of air or breathable gas, cool the air or breathable gas, and output cooled air or breathable gas which is delivered to a human subject. A flow control device controls a flow rate of the flow of the air or breathable gas input to the cooling subsystem and a flow rate of the cooled air or breathable gas delivered to the human subject. One or more flow rate sensors measure at least a flow rate of flow of cooled air or breathable gas. One or more temperature sensors measure at least a temperature of a brain and the temperature of the flow of cooled air or breathable gas. A controller adjusts a cooling rate, the temperature, and the flow rate of flow of cooled air or breathable gas delivered to the human subject to cool the brain of the human subject.

A system for cooling the brain of a human subject, includes a cooling subsystem which inputs a flow of air or breathable gas, cool the air or breathable gas, and output cooled air or breathable gas which is delivered to a human subject. A flow control device controls a flow rate of the flow of the air or breathable gas input to the cooling subsystem and a flow rate of the cooled air or breathable gas delivered to the human subject. One or more flow rate sensors measure at least a flow rate of flow of cooled air or breathable gas. One or more temperature sensors measure at least a temperature of a brain and the temperature of the flow of cooled air or breathable gas. A controller adjusts a cooling rate, the temperature, and the flow rate of flow of cooled air or breathable gas delivered to the human subject to cool the brain of the human subject.

An improved device delivers a fluid medicament to the subcutaneous tissue of a user. The device is better suited for patients with Parkinson's Disease and other central nervous system disorders, than conventional infusion devices. The device can include a reusable part including a drive component (e.g., motor) and control electronics and a disposable part including a medicament reservoir. Medicament can be evacuated from the medicament reservoir by a plunger assembly that includes a plunger attached to a lead screw that is rotated by a nut, all within the disposable part. The device can be fluidically coupled with the tissue via a flexible cannula. Various embodiments relate to an improved cannula insertion mechanism that delivers the cannula under a force applied by a spring. Various embodiments relate to improved filling of the device, for example, using a vial adapter and an automated filling station.

A fluid infusion system includes an air pump connected to an accumulator tank to produce pressurized air that is stored in the accumulator tank. The system can include one or more fluid bag chambers wherein each fluid bag chamber includes an inflatable bladder positioned inside the fluid bag chamber to apply pressure on the fluid bag supported inside the chamber. The fluid bag can be connected by a tube set to deliver fluid from the fluid bag to a surgical tool at a surgical site. The fluid can, for example, be irrigation fluid or distention fluid. The system can include a controller connected to the pump to control the pump to produce the pressurized air and an adjustable pressure regulator can be connected between the accumulator tank and the inflatable bladder to control the pressure of air delivered to the inflatable bladder and the pressure that the fluid is delivered to the surgical tool. A pressure sensor can be connected between the adjustable pressure regulator and the inflatable bladder to measure the air pressure delivered to the inflatable bladder and send the air pressure measurements to the controller. The controller can configure the system display to show the air pressure measured by the pressure sensor.

The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.

The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.

A medical fluid probe includes a heat spreader structure that defines therein a fluid chamber that is in fluid communication with an external environment around the probe, and a thermal energy source in thermal communication with the heat spreader structure. The heat spreader structure functions as both temperature-control elements and structural elements. A variety of separate structure elements, such as the heat pipes, may combine to form the heat spreader structure. The thermal energy source may be used to maintain the temperature of the heat spreader structure, such as by heating and/or cooling the heater spreader structure.

A medical fluid probe includes a heat spreader structure that defines therein a fluid chamber that is in fluid communication with an external environment around the probe, and a thermal energy source in thermal communication with the heat spreader structure. The heat spreader structure functions as both temperature-control elements and structural elements. A variety of separate structure elements, such as the heat pipes, may combine to form the heat spreader structure. The thermal energy source may be used to maintain the temperature of the heat spreader structure, such as by heating and/or cooling the heater spreader structure.

A pump for treating a patient is disclosed that includes a plunger transitionable between a first position and a second position, wherein when a tube is loaded within the pump, the plunger applying a force against the tube when in the second position; a cam shaft configured to actuate the plunger to transition the plunger from the first position to the second position; a motor coupled to the cam shaft; a heatsink to dissipate heat from the motor, the heatsink including a first part and a second part; and a housing containing at least a portion of the plunger, the cam shaft, the motor and the heatsink, the first part of the heatsink extending through a surface of the housing, the second part is thermally in contact with the motor, and the first and second parts of the heatsink are movable relative to one another to define an adjustable length.

A low leakage current fluid heater and systems and methods thereof. The fluid heater has a configuration whereby a heating element is isolated from a fluid channel so as to leak into fluid passing through the channel an allowed amount of leakage current. Fluid passing through the fluid heater can be heated to a desired temperature. A controller can provide control signals to driver the fluid heater to the desired temperature and maintain the temperature at the desired temperature.