There is disclosed a heating device which is adapted to be used to warm medical solutions contained within medical devices such as an intravenous bag, intravenous tube or respiratory circuit. The heating device includes an elongated flexible material tube having an interior medical solution channel and a pair of heat channels. The heat channels are filled or coated with a flexible, electrically conductive substance, which forms an electrical resistor. The conductive substance is electrically coupled to an electric power source controller. Electric current passing through the conductive substance creates heat which is transferred from the heat channels to the medical solution contained within the interior medical solution channel.

There is disclosed a heating device which is adapted to be used to warm medical solutions contained within medical devices such as an intravenous bag, intravenous tube or respiratory circuit. The heating device includes an elongated flexible material tube having an interior medical solution channel and a pair of heat channels. The heat channels are filled or coated with a flexible, electrically conductive substance, which forms an electrical resistor. The conductive substance is electrically coupled to an electric power source controller. Electric current passing through the conductive substance creates heat which is transferred from the heat channels to the medical solution contained within the interior medical solution channel.

A heating unit comprising an electrically conductive substrate. A solid fuel layer comprising a metal reducing agent, a metal containing oxidizing agent and a binder is coated on a surface of the substrate, the solid fuel layer having a solid fuel surface spaced from the substrate. A first electrode coupled to the substrate. A second electrode coupled to the solid fuel surface. A power supply is configured to be selectively coupled to the first and second electrodes to provide a voltage between the metallic substrate and the solid fuel surface. The voltage acts to propagate an exothermic metal oxidation-reduction reaction without the use of an igniter.

The apparatus pre-treats fluid and then delivers it to a patient during surgery, for example a hyperthermic intra-peritoneal chemotherapy (HIPEC) procedure. It comprises a reservoir (2) for the fluid, a reversible pump (10) and a valve assembly (22). In a recirculation mode, the pump (10) is operated in one direction to draw fluid from the reservoir (2), through the valve assembly (22) and back to the reservoir (2), while the fluid is pre-treated by heating, for example. In a fluid delivery mode, the pump (10) is operated in an opposite direction to draw fluid from the reservoir (2) and deliver the fluid through the valve assembly (22) to a port (30) from which it can be supplied to the patient. A second pump (12) may be provided for drawing fluid from the patient via a return port (48). The pumps (10,12) may be peristaltic pumps integrated with the walls of the reservoir (2).

A heating unit comprising an electrically conductive substrate. A solid fuel layer comprising a metal reducing agent, a metal containing oxidizing agent and a binder is coated on a surface of the substrate, the solid fuel layer having a solid fuel surface spaced from the substrate. A first electrode coupled to the substrate. A second electrode coupled to the solid fuel surface. A power supply is configured to be selectively coupled to the first and second electrodes to provide a voltage between the metallic substrate and the solid fuel surface. The voltage acts to propagate an exothermic metal oxidation-reduction reaction without the use of an igniter.

A heating unit comprising an electrically conductive substrate. A solid fuel layer comprising a metal reducing agent, a metal containing oxidizing agent and a binder is coated on a surface of the substrate, the solid fuel layer having a solid fuel surface spaced from the substrate. A first electrode coupled to the substrate. A second electrode coupled to the solid fuel surface. A power supply is configured to be selectively coupled to the first and second electrodes to provide a voltage between the metallic substrate and the solid fuel surface. The voltage acts to propagate an exothermic metal oxidation-reduction reaction without the use of an igniter.

The present disclosure provides methods of preparing a medical solution. In some aspects, the medical solution can be prepared from mixing a first liquid with a second liquid or mixing a solid component with a liquid in an autoinjector. In some aspects, the heat released from the mixing can promote solubility of a dry medicament in the solution.

The present disclosure provides methods of preparing a medical solution. In some aspects, the medical solution can be prepared from mixing a first liquid with a second liquid or mixing a solid component with a liquid in an autoinjector. In some aspects, the heat released from the mixing can promote solubility of a dry medicament in the solution.

Disclosed herein is an auto injector for administering a medicament, the auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge comprising a first stopper and a cartridge compartment containing the medicament, the cartridge compartment having a first cartridge subcompartment containing a first medicament component of the medicament and a second cartridge subcompartment containing a second medicament component of the medicament; a drive module coupled to move a plunger rod between a retracted plunger rod position and an extended plunger rod position, the plunger rod being configured to move the first stopper; a processing unit coupled to the drive module, wherein the processing unit is configured to control the drive module to move the plunger rod from a first plunger rod position to a mix plunger rod position with a mix plunger rod speed, wherein the mix plunger rod position is selected to position the first stopper in a position wherein the first medicament component is mixed with the second medicament component, and to provide an onset signal after a number of completed inversions of the auto injector has been performed.

Disclosed herein is an auto injector for administering a medicament, the auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge comprising a first stopper and a cartridge compartment containing the medicament, the cartridge compartment having a first cartridge subcompartment containing a first medicament component of the medicament and a second cartridge subcompartment containing a second medicament component of the medicament; a drive module coupled to move a plunger rod between a retracted plunger rod position and an extended plunger rod position, the plunger rod being configured to move the first stopper; a processing unit coupled to the drive module, wherein the processing unit is configured to control the drive module to move the plunger rod from a first plunger rod position to a mix plunger rod position with a mix plunger rod speed, wherein the mix plunger rod position is selected to position the first stopper in a position wherein the first medicament component is mixed with the second medicament component, and to provide an onset signal after a number of completed inversions of the auto injector has been performed.