A reusable instrument handle with single-use tip may include an instrument tip and an instrument handle. The instrument tip may include an outer base, a nosecone, a pressure mechanism, a hypodermic tube, a blank, a fixation mechanism, and a tip cover. The instrument handle may include an actuation structure, a fixation mechanism receptacle, and an instrument tip housing. The fixation mechanism and the fixation mechanism receptacle may be configured to temporarily fix the instrument tip in the instrument tip housing. A compression of the actuation structure may be configured to actuate the hypodermic tube relative to the blank. The instrument tip may be removed from the instrument tip housing after use by removing the fixation mechanism from the fixation mechanism receptacle.

A reusable instrument handle with single-use tip may include an instrument tip and an instrument handle. The instrument tip may include an outer base, a nosecone, a pressure mechanism, a hypodermic tube, a blank, a fixation mechanism, and a tip cover. The instrument handle may include an actuation structure, a fixation mechanism receptacle, and an instrument tip housing. The fixation mechanism and the fixation mechanism receptacle may be configured to temporarily fix the instrument tip in the instrument tip housing. A compression of the actuation structure may be configured to actuate the hypodermic tube relative to the blank. The instrument tip may be removed from the instrument tip housing after use by removing the fixation mechanism from the fixation mechanism receptacle.

A locking mechanism is provided for use with a reservoir and a reservoir holder so as to prevent unwanted tampering with the reservoir. The mechanism comprises a main body with an aperture that is coupled to the reservoir. A hinged flange is provided on the main body. The flange folds inwards at the pivot point provided by the hinge, toward the aperture of the main body, allowing the mechanism to pass over the ferrule of the reservoir. Once the mechanism is placed over the cartridge, the flange folds toward the reservoir at the pivot point, flexing away from the main body. The flange rests against the underside of the reservoir ferrule, thereby retaining the reservoir within the locking mechanism. The locking mechanism may be for use with either a disposable or a reusable delivery device.

A syringe for use with a medical injector system includes a barrel and a semi-rigid hub, the hub having an outer surface adapted to slidingly move within the barrel, and an inner surface having a continous circumferential wall. The hub further includes an annular engaging portion recessed within at least part of the continous circumferential wall forming a groove, at least one radially extendable and retractable retention member disposed at partially within a proximal cylindrical portion of the hub, and the elastometric seal engaged with a seal engaging portion on the hub and slidingly engaged with the barrel of the syringe. The semi-rigid hub and the elastomeric seal are reciprocally slidable within the barrel, and the at least one radially entendable and retractable retention member is configured to releasably engage the groove upon retraction of the plunger to permit the semi-rigid hub to be selectively withdrawn within the barrel.

An injection device (100), including a base (104), a sliding body (116) slidably connected to the base (104), a double-ended needle (120) fixed to the sliding body (116), a biasing member (124) for proximally biasing the sliding body (116) with respect to the base (104), and for retracting the needle (120) into the device (100) subsequent to activation of the device (100), a medicament cartridge (128) for holding a medicament, slidably connected to the sliding body (116), and a stopper (132) slidably disposed within the medicament cartridge (128). The base (104) has a proximal end (108) and a surface (164) disposed at a distal end (112) thereof for contacting a patient's skin. The base (104) also has a first locking mechanism. The sliding body, (116) has a locking feature and a second locking mechanism. The second locking mechanism locks the medicament cartridge (128) relative to the sliding body (116) upon completion of displacement of the medicament cartridge (128) relative to the sliding body (116). The first locking mechanism and the locking feature interact to lock the sliding member (116) relative to the base subsequent to retraction of the needle (120) into the device (100).

An injection device (100), including a base (104), a sliding body (116) slidably connected to the base (104), a double-ended needle (120) fixed to the sliding body (116), a biasing member (124) for proximally biasing the sliding body (116) with respect to the base (104), and for retracting the needle (120) into the device (100) subsequent to activation of the device (100), a medicament cartridge (128) for holding a medicament, slidably connected to the sliding body (116), and a stopper (132) slidably disposed within the medicament cartridge (128). The base (104) has a proximal end (108) and a surface (164) disposed at a distal end (112) thereof for contacting a patient's skin. The base (104) also has a first locking mechanism. The sliding body, (116) has a locking feature and a second locking mechanism. The second locking mechanism locks the medicament cartridge (128) relative to the sliding body (116) upon completion of displacement of the medicament cartridge (128) relative to the sliding body (116). The first locking mechanism and the locking feature interact to lock the sliding member (116) relative to the base subsequent to retraction of the needle (120) into the device (100).

A self-injection device with a miniaturized drug delivery portion is provided. The device includes a housing (10) having an interior volume and the drug delivery portion (20) has a volume enclosed within the housing. The drug delivery portion includes a reservoir (30) containing a fluid to be delivered to a user and a microneedle (22) in fluid communication with the reservoir and extendable through the housing. The drug delivery portion also includes a drive mechanism for expelling fluid from the reservoir through the microneedle, wherein the volume of the drug delivery portion is less than 40% of the interior volume of the housing. The volume of the drug delivery portion may be less than 30% of the interior volume of the housing.

An exemplary embodiment of an injector includes a trigger mechanism, an energy source, and a user-operable firing-initiation member. The trigger mechanism can include a floating trigger member having a retaining portion, a ram assembly having a ram configured to pressurize a medicament container for expelling a medicament therefrom, the ram assembly further having a floating trigger engagement member configured to engage the retaining portion of the floating trigger member when the floating trigger member is in a pre-firing condition. The energy source can be associated with the ram for powering the ram to expel the medicament, and the user-operable firing-initiation member can be operable for causing an axial rotation of the floating trigger member from the pre-firing condition to a firing condition in which the floating trigger engagement member is released from the retaining portion to allow the energy source to fire the ram.

A needle actuator assembly for a drug delivery system includes a housing, a needle having retracted and extended positions, a needle actuator body received within the housing and configured to move from a pre-use position where the needle is in the retracted position to a use position where the needle is in the extended position and to a post-use position where the needle is in the retracted position, with the needle actuator having a button contact surface, and an actuator button received by the housing.

A tamper-evident syringe tip cap is provided and includes an outer housing with an outer shell, and a tip cover secured to an upper end of the outer shell. An inner core has a female Luer lock fitting, a spindle projecting vertically from the fitting, and a sleeve matingly engaging the spindle and being constructed and arranged for releasably securing the outer housing to the inner core. The outer housing is movable relative to the inner core between a first, pre-activated position and a second, activated position.