A closure assembly for a medical device, preferably in the form of a tamper evident closure, having an outer sleeve including an open end and a closed end. A tip cap includes a flow restrictor disposed within the sleeve in accessible relation by the medical device through the open end. An indicator member is removably connected to the tip cap within the sleeve and a retainer member is connected to an interior of the sleeve in an interruptive, disconnecting relation to the indicator member by a snap-fit connection. The indicator member is captured within said hollow interior upon removal of said tip cap from the sleeve through the open end. An end cap may be attached to the sleeve, to define a closed end thereof, by a snap-fit connection similar to, but distinguishable from, the snap-fit connection between the retainer member and the interior of the sleeve.

A plunger rod (104) for use in connection with a syringe barrel (102) is provided. The plunger rod (104) comprises a distal plunger top (105), having a proximal bottom surface (113), and a proximal elongated shaft (106) comprising a proximal end (107a) adapted to receive an applied force along an axis (1000) and a distal end plate (107b) adapted to transmit said applied force along said axis (1000). The plunger rod (104) is adapted to be inserted into the barrel (102) of a syringe (100) extending along the axis (1000). The distal plunger top (105) and the proximal elongated shaft (106) are connected to each other by a releasable connection (115). The releasable connection (115) comprises: distal top rupture means (116) comprising at least one distal top rib (125a) disposed eccentrically from the axis (1000) on the proximal bottom surface (113), and proximal shaft rupture means (117) comprising at least one proximal shaft rib (125b) disposed eccentrically from the axis (1000) on the distal end plate (107b). Each said at least one distal top rib (125a) is connected to a corresponding at least one proximal shaft rib (125b), said ribs (125a, 125b) being connected at a contact area (118), and wherein said distal top rupture means (116) is configured to detach from the proximal shaft rupture means (117) due to compression failure when the distal plunger top (105) is pushed into a distal end (110) of the barrel (102). A syringe is also provided.

A plunger rod (104) for use in connection with a syringe barrel (102) is provided. The plunger rod (104) comprises a distal plunger top (105), having a proximal bottom surface (113), and a proximal elongated shaft (106) comprising a proximal end (107a) adapted to receive an applied force along an axis (1000) and a distal end plate (107b) adapted to transmit said applied force along said axis (1000). The plunger rod (104) is adapted to be inserted into the barrel (102) of a syringe (100) extending along the axis (1000). The distal plunger top (105) and the proximal elongated shaft (106) are connected to each other by a releasable connection (115). The releasable connection (115) comprises: distal top rupture means (116) comprising at least one distal top rib (125a) disposed eccentrically from the axis (1000) on the proximal bottom surface (113), and proximal shaft rupture means (117) comprising at least one proximal shaft rib (125b) disposed eccentrically from the axis (1000) on the distal end plate (107b). Each said at least one distal top rib (125a) is connected to a corresponding at least one proximal shaft rib (125b), said ribs (125a, 125b) being connected at a contact area (118), and wherein said distal top rupture means (116) is configured to detach from the proximal shaft rupture means (117) due to compression failure when the distal plunger top (105) is pushed into a distal end (110) of the barrel (102). A syringe is also provided.

A drug delivery device is provided, including a housing, a drug storage container, a plunger, a plunger biasing member, a releaser, and a shock absorber. The housing defines a longitudinal axis and has an opening. The drug storage container includes a barrel, a stopper, and a delivery member, where the stopper is movably positioned within the barrel. The delivery member is positioned at a distal end of the barrel and has an insertion end configured to extend at least partially through the opening during a delivery state. The plunger is moveable toward the distal end of the drug storage container to engage the stopper and expel a drug from the drug storage container through the delivery member. The plunger biasing member is coupled with the plunger and configured to urge the plunger toward the distal end of the drug storage container. The releaser member has a first position wherein the releaser member prevents the plunger from moving into the delivery state and a second position wherein the releaser member does not prevent the plunger from moving into the delivery state. The shock absorber is configured to absorb an impact force and prevent unintended movement of the releaser member.

Injection monitoring circuitry is provided for coupling to part of an injection device having a syringe and a plunger rod. The injection monitoring circuitry has an input to receive force measurement data from a force sensor, the force measurement data includes a plurality of timestamped force measurements of force applied by a user to the injection device when an injection is administered to an injection site. Processing circuitry is provided to determine from the force measurement data when an end of injection has been reached, the end of injection corresponding to the plunger rod having reached an end position in a distal portion of the barrel of the syringe during administration of the injection by the user. Machine readable instructions and an injection monitoring method are also provided.

A system for priming an infusion pump is disclosed. The system includes a priming cap including a septum and configured to matably connect with a male part comprising a needle and attached to a length of tubing for fluid, wherein when matably connected with the male part, the priming cap occludes the tubing.

Devices, systems, and methods are provided herein for delivering medication (e.g., insulin) via a wearable pump having a patch-style form factor for adhesion to a user's body. The reusable pump may be coupled to a disposable cap housing a microdosing system for delivering precise, repeatable doses of medication to a cannula configured to deliver medication to a target infusion area beneath the user's outer skin layer. The system further may include an applicator for inserting the cannula into the user's skin and/or applying an adhesive pad to the skin.

A system for treating heart disease, such as pulmonary hypertension or right heart failure, including an implantable component and external components for monitoring the implantable component is provided. The implantable component may include a compliant member, e.g., balloon, coupled to a reservoir via a conduit. Preferably, the compliant member is adapted to be implanted in a pulmonary artery and the reservoir is adapted to be implanted subcutaneously. The external components may include a clinical controller component, monitoring software configured to run a clinician's computer, a patient monitoring device, and a mobile application configured to run on a patient's mobile device.

A disposable safety syringe needle and a syringe device including the same are provided, which can prevent reuse and an accident in safety, in which injury can be sustained by the needle. The disposable safety syringe needle includes: an upper part to which an elastic member is coupled and in which a needle member is inserted; a lower part which is coupled to one end of the upper part, and which includes one or more catching parts; and a safety part which is coupled to one end of the lower part, and which includes a catching protrusion, wherein the safety part is inserted into the lower part toward the upper part so that the elastic member is compressed, and the catching protrusion of the safety part is coupled to the one or more catching parts by the stretching force of the elastic member so as to disable reuse.

A disposable safety syringe needle and a syringe device including the same are provided, which can prevent reuse and an accident in safety, in which injury can be sustained by the needle. The disposable safety syringe needle includes: an upper part to which an elastic member is coupled and in which a needle member is inserted; a lower part which is coupled to one end of the upper part, and which includes one or more catching parts; and a safety part which is coupled to one end of the lower part, and which includes a catching protrusion, wherein the safety part is inserted into the lower part toward the upper part so that the elastic member is compressed, and the catching protrusion of the safety part is coupled to the one or more catching parts by the stretching force of the elastic member so as to disable reuse.