An atomizing nozzle structured particularly for nasal therapy. Preferred embodiments include a 2-piece atomizing nozzle structured to couple with luer-locking structure carried by a syringe. Such an atomizing nozzle includes a nasal stopper and a stem. A preferred nasal stopper includes a distal tip sized for insertion into a nostril of a human child, with a proximal shield portion being structured to resist over-insertion of a discharge orifice into the nostril. A nasal stopper desirably provides a centering function to urge the discharge orifice away from a nasal wall. One operable stem is structured to couple with the stopper and desirably carries unitary thread structure at a proximal end. A second operable stem is structured as a unitary part of the nasal stopper and also desirably carries unitary thread structure at a proximal end. Certain embodiments may also include spacer structure configured to reduce a dead volume inside the atomizing nozzle. Other embodiments may also include spacer structure configured to reduce dead volume inside a syringe that is coupled to the atomizing nozzle.

Methods and compositions are disclosed for the treatment of taste and smell disorders. The compositions comprise phosphodiesterase inhibitors and are formulated for intranasal administration.

Therapeutic powder applicators and their methods of operation are described. In some embodiments, a first flow of gas may flow through a distal porous portion of a chamber containing a therapeutic powder. This gas may fluidize and entrain the therapeutic powder and flow the entrained powder through an outlet that is in fluid communication with the chamber.

A nebulizer for medicament is provided. The nebulizer includes a cup having an interior surface. An axle is attached to the cup at least at a location along a central axis of the cup such that rotation of the axle causes a rotation of the cup about the central axis. A fan is operably attached to the axle and configured to generate a flow of air adjacent to the cup. A drum is disposed around a circumference of the cup, and configured to contain the generated flow of air near the cup. A conduit is configured to receive liquid medicament and deposit such medicament on a surface of the cup.

The invention relates to an inhaler comprising a housing with a mouth end, at least one air inlet opening and an air channel extending into the housing between the at least one air inlet opening and the mouth end, a receiving area for a fluid reservoir, an electric energy accumulator, a supply device for generating steam and/or aerosol from a component mixture extracted from the fluid reservoir and adding the steam and/or the aerosol to an air flow flowing into the air channel, wherein the supply device comprises an evaporator which can be controlled separately and a control device for controlling the supply device. The control device is connected or can be connected a data store in which at least one set predefining the evaporating parameters can be called upon and stored therein for evaporating the component mixture in the evaporator.

An apparatus for treating dry eye, comprising composition chambers respectively containing a first composition and a second composition, wherein the first composition includes 95%-100% of aqueous substances and the second composition includes 95-100% volume of non-aqueous substances; and an air pump that is fluidically connected to the composition chambers and sequentially generates and propels the mists of the first composition and the second composition to a surface that corresponds to a cornea of an eye. The first mist, including droplets of the one or more aqueous substances forms a first film layer that corresponds to an aqueous layer of an artificial tear film, the second mist has a volume within a range of 0.1-3 microliters, and includes droplets of the one or more non-aqueous substances forms a second film layer that corresponds to a lipid layer of the artificial tear film with a thickness within a range of 10 nm-200 nm.

Compositions, devices, and methods for treating one or more respiratory disorders in a subject (e.g., a mammal) are provided. In an exemplary embodiment, a breathing system is provided and include a pressure-assisted breathing device, and a composition comprising amniotic fluid, an amnion tissue preparation, or a combination thereof. The pressure-assisted breathing device can be a mechanical ventilator. The breathing system can further include a delivery device selected from a nebulizer, a metered dose inhaler, or a dry powder inhaler operably connected to the breathing system to deliver the composition into the breathing system.

Devices, and methods for generating variable inhalable products (e.g., variable density, phase, and size products) are provided. Methods for treating or preventing a disorder in a subject using variable products generated by the devices are also provided herein. Additionally, inhalers and breathing systems comprising the devices are provided.

Embodiments herein describe a portable device for administering a physiologically active liquid that includes a container for holding the liquid, pressurizing means for applying pressure to the liquid, an atomizer for atomizing the liquid, and an applicator for administering atomized liquid. The atomizer includes at least one nozzle through which liquid can be ejected from the container and an impact element on the nozzle outlet side that is functionally combined with the nozzle. Moreover, the atomizer is configured in such a way that, in a pressure range that can be generated with the pressurizing means, liquid emerging from the nozzle breaks up into droplets prior to striking the impact element.

An in-line droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The in-line droplet delivery device includes a housing, a mouthpiece, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The in-line droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The in-line droplet delivery device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 μm, so as to target the pulmonary system of the user. the droplet delivery device is configured in an in-line orientation in that the housing, its internal components, and various device components (e.g., the mouthpiece, air inlet flow element, etc.) are orientated in a substantially in-line or parallel configuration (e.g., along the airflow path) so as to form a small, hand-held device.