The present disclosure is directed to a pre-filled container configured to store a pre-defined volume of a vaporizable liquid composition. The present disclosure is also directed to personal vaporizing devices for using such containers. In one embodiment, the pre-filled container is configured to provide a vaporizable liquid composition stored therein to an ultrasonic vaporizing component via capillary action for vaporization thereof.

A system for respiratory therapy may include a nebulizer, an adaptor, and a nasal cannula. The nebulizer is operable to generate an aerosolized medicament and pass the aerosolized medicament through a nebulizer outlet port. The adaptor has a nebulizer coupling port configured to be coupled to the nebulizer outlet port. The nasal cannula is configured to provide a flow of breathing gas from a breathing gas source to the patient. The nasal cannula includes at least one nasal prong and an attachment device positioned adjacent the at least one nasal prong. The attachment device is configured to secure the adaptor outlet port adjacent an outlet of the nasal prong. A method includes securing a nasal cannula to the patient, attaching an adaptor to the nasal cannula, generating an aerosolized medicament, transferring the aerosolized medicament into the adaptor, and providing a flow of breathing gas to the patient.

The present invention provides a method and apparatus for reducing condensation in a respiratory circuit during a delivery of humidifying agent into the respiratory circuit. A first amount of humidification agent to a first volume of gas is delivered to a patient respiratory circuit during a patient inhalation cycle or immediately after a patient exhalation cycle, and the humidification agent or the first volume of gas is heated. Condensation is removed from the respiratory circuit at least in part by providing, during a patient exhalation cycle or immediately after a patient inhalation cycle, a second amount of the humidification agent to a second volume of gas being delivered from the gas source to the patient respiratory circuit, the second amount of the humidification agent being significantly less than the first amount of the humidification agent.

A droplet delivery device with an ejector mechanism and fluid reservoir includes an accelerometer to determine and communicate optimized mixing of fluid in the reservoir for inhalation of droplets, such as into the lungs, from the droplet delivery device.

An optimization methodology is employed to match vibratory inhaler devices having certain characteristics to the particular anatomical and acoustic properties of a patient's vocal tract, in order to achieve the most effective dispersion of a dry powder medicament using inspiratory effort of a user of the inhaler. In embodiments, optimization involves employing one or more measurements of acoustic frequency spectrum properties as well as one or more anatomical/geometric measurements of the structures comprising the particular patient's mouth, pharynx, and upper respiratory tract and matching a vibratory inhalation device that corresponds thereto.

The present invention relates to a handheld vibrating mesh nebuliser for delivery of a medicament to the respiratory system in therapy. The present invention also relates to a supply container for loading the nebuliser with liquid medicament. The present invention also relates to a kit for delivery of a medicament to a respiratory system and a method of loading a vibrating mesh nebuliser with liquid medicament from a supply container. The present invention also relates to compositions for use in a method of treatment of a respiratory disease in a patient by therapy.

Methods and systems are provided for delivering anesthetic agent to a patient. In one embodiment, an anesthetic vaporizer includes a sump configured to hold a liquid anesthetic agent; an ultrasonic transducer coupled to a bottom of the sump and at least partially disposed within the sump; a vaporizing chamber fluidically coupled to the sump; and a heating element coupled to the vaporizing chamber and configured to increase a temperature of a surface disposed within the vaporizing chamber.

Embodiments of the present invention include inhalable composition, comprising milrinone or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable carrier, an excipient, a surfactant; the composition being capable of being administered by inhalation.

A nebuliser for nebulising liquid droplets, including: a housing; at least one piezoelectric substrate (2) accommodated within the housing and having a transducer surface (2a) upon which is located at least one electroacoustic transducer (48) for generating acoustic wave energy within the at least one piezoelectric substrate (2), and an opposing non-transducer surface (2b); a liquid supply system for supplying a liquid to at least one of the transducer and non-transducer surfaces, the liquid supply system including a reservoir (3) for accommodating the liquid, and at least one relatively rigid supply conduit in contact with the at least one piezoelectric substrate (2) for supplying the liquid from the reservoir (3) to the at least one piezoelectric substrate (2); and a sensor for detecting a volume of liquid on the at least one piezoelectric substrate (2).

The invention relates to an ultrasonic mist inhaler (100), comprising a liquid reservoir structure (2) comprising a liquid chamber (21) adapted to receive liquid to be atomized, a sonication chamber (22) in fluid communication with the liquid chamber (21); wherein the liquid reservoir structure (2) comprises the sonication chamber (22).