Embodiments of the application involve a formulation of Fluticasone Propionate in the form of a suspension, gel or dry powder comprising Fluticasone Propionate, Fluticasone Furoate, Micronized Fluticasone Propionate or Micronized Fluticasone Furoate or other corticosteroids. Additional pharmaceutical components of the formulation may allow for the adherence and duration of the active ingredient to the inflamed esophageal tissues. The resulting medication formulation is then targeted with a drug delivery device and applied directly to the oropharynx bypassing the oral cavity altogether. The medication then flows down the back of the throat to the esophagus. By passing the oral cavity prevents the corticosteroid drug from being absorbed into the bloodstream through oral cavity tissues, helping to prevent harmful side effects. Additional side effects are avoided by using the medication Fluticasone, which exhibits exceptionally low gastrointestinal absorption.

The present invention is directed to a device for expression of a hemostatic powder having an elongated reservoir with a manual air pump, such as a bellows, at a proximal end and an expression port at a distal end. A porous filter is slidably disposed within the reservoir between the bellows, a plunger and the expression port, and a spring is disposed within the reservoir between the air pump and the plunger. The powder is disposed within the reservoir between the porous filter and the expression port, and the pump is in a fluid communication with the expression port through the porous filter and through the powder.

The present invention relates to a medical instrument for the targeted introduction of a substance into a body cavity and to a tool (1) therefor. According to the invention, the tool (1) has a shaft (2) with a lumen (6), on the distal end (1″) of which is situated a nozzle head (3) with at least two nozzles (4), wherein the nozzles (4) are spaced from each other at an angle of less than 180° and equally relative to a centre axis (M) of the shaft (2).

The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.

Systems and methods are provided for anesthetizing a tympanic membrane of an ear. The systems are personalizable to ensure proper anesthetizing solution administration. The systems and methods may also be useful for administering a solution to the ear canal of a human patient and for maintaining the solution therein.

Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are provided. Methods of treating opioid overdose or its symptoms with the inventive drug products are also provided.

A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device including a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which the substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.

An inhalation device including a housing, which encloses a liquid reservoir in which the liquid is stored before discharge, and an applicator head with a nebulization chamber and an applicator piece connected thereto, wherein the applicator piece is designed either as a mouthpiece, to be received in the mouth of a patient, or as an inhalation mask, to sealingly cover the mouth, the nose, or the mouth and the nose. The inhalation device furthermore has a discharge channel which connects the liquid reservoir to the applicator head. The inhalation device includes at the end of the discharge channel a nozzle plate with a large number of nozzle openings which serve to generate an inhalation mist and through which the liquid from the liquid reservoir is conveyed into the nebulization chamber.

A system and method for controlling a locking medication dispensing device is presented herein. The dispensing device can include a housing portion and a nozzle portion that is depressible into the housing to administer a medication. The device can include a vial lock to secure a medicinal vial within the device and a nozzle lock to control administration of medication. The dispensing device can further include sensors for identifying a user such as a biometric sensor and/or micro gesture sensors. Parameters for locking the nozzle and/or vial can be configured via a physician device. Reminders, user pairing, and other user communications can be facilitated via a patient device. The dispensing device can include partial depression sensors and lock-out features to further prevent tampering. A top-loading dispensing device can include a disposable nozzle.

Cartridges are configurable between a closed state and an open state. The cartridges include a cartridge body and a reservoir disposed in the cartridge body. The cartridge body has an outer locking element, and the reservoir has a rotational locking element. In the closed state, the outer locking element engages the rotational locking element such that the reservoir cannot be rotated out of a first rotational position relative to the cartridge body in which a fluid outlet of the reservoir is not in fluid communication with a fluid outlet of the cartridge body. In the open state, the outer locking element of the cartridge body does not engage the rotational locking element of the reservoir, and the reservoir is in a second rotational position relative to the cartridge body such that the fluid outlet of the reservoir is in fluid communication with the fluid outlet of the cartridge body.