Methods are provided for acute treatment of agitation, including agitation in patients with schizophrenia or bipolar disorder, comprising administering to a subject with agitation an effective dose of a dry pharmaceutical composition comprising olanzapine, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma olanzapine concentration (C.sub.max) of at least 30 ng/mL, with (b) a mean time to C.sub.max (T.sub.max) of olanzapine of less than 0.5 hours. Dry pharmaceutical compositions and devices suitable for intranasal delivery of olanzapine are provided.

A medical device is provided for irrigation of a patient wound site. The device contains a tube having a proximal portion adapted to receive an irrigation solution, a distal portion having a nozzle and an intermediate portion for transporting the solution. The tube has a barrel portion that may be manipulated by a user to position the device relative to the wound site. A distinctive nozzle has a body formed with a distally leading channel presenting a semispherical first spatial conformation and a proximally leading opening formed in the body presenting a second spatial conformation intersecting the semispherical terminus. This geometry, derived from principles of flow mechanics discussed herein, defines what will be described as an “effective diameter” of the nozzle. An assembly and system utilizing the device are also disclosed. The invention utilizes a fluid-isolating durable peristaltic pump for a continuous flow of irrigation solution, along with a single use tube set that embodies the device.

An apparatus for treating dry eye, comprising composition chambers respectively containing a first composition and a second composition, wherein the first composition includes 95%-100% of aqueous substances and the second composition includes 95-100% volume of non-aqueous substances; and an air pump that is fluidically connected to the composition chambers and sequentially generates and propels the mists of the first composition and the second composition to a surface that corresponds to a cornea of an eye. The first mist, including droplets of the one or more aqueous substances forms a first film layer that corresponds to an aqueous layer of an artificial tear film, the second mist has a volume within a range of 0.1-3 microliters, and includes droplets of the one or more non-aqueous substances forms a second film layer that corresponds to a lipid layer of the artificial tear film with a thickness within a range of 10 nm-200 nm.

Compositions, devices, and methods for treating one or more respiratory disorders in a subject (e.g., a mammal) are provided. In an exemplary embodiment, a breathing system is provided and include a pressure-assisted breathing device, and a composition comprising amniotic fluid, an amnion tissue preparation, or a combination thereof. The pressure-assisted breathing device can be a mechanical ventilator. The breathing system can further include a delivery device selected from a nebulizer, a metered dose inhaler, or a dry powder inhaler operably connected to the breathing system to deliver the composition into the breathing system.

A handheld assembly for dispensing a medicament to a subject is provided. The assembly includes a unit dose device, a shell, a plunger, a dispense button, a drive member and an escapement that is movable and capable of cycling the dispense assembly thru multiple states of a dispense cycle.

A portable nebulizer provided by the invention is particularly suitable for using with a liquid contained in a capsule or in a container made of a disposable material that can be easily damaged, the portable nebulizer comprises a driving unit for driving an atomizing unit, and a containing unit for containing the container, the containing unit has a breaking part for breaking the container to facilitate outflow of the liquid, after the liquid flows into an inner space of a main body of the containing unit because the container is damaged by the breaking part, the liquid can be atomized by the atomizing unit to produce a mist capable of escaping to the outside of the main body for a user to use the liquid mist conveniently.

A docking station for a hand-held filament extension atomizer device includes a receiver to receive the device, station electronics, a recharging point for the device arranged to connect with a power source of the device, a power connection to an alternating current power source, and a cleaning reservoir of cleaning solution. A method of operating hand-held dispenser to dispense fluid as a mist includes receiving a signal at a motor contained in a casing in response to a user triggering an actuator on the casing, activating the motor to provide fluid to a filament extension atomizer contained in the case from a reservoir contained in the casing, the motor to cause the filament extension atomizer to generate a mist, and using an air source contained in the casing arranged adjacent the filament extension atomizer to provide air flow to direct the mist to a nozzle that is arranged to allow the mist to exit the casing.

A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device comprising: a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.

The present invention is directed to a device for expression of a hemostatic powder having an elongated reservoir with a manual air pump, such as a bellows, at a proximal end and an expression port at a distal end. A porous filter is slidably disposed within the elongated reservoir between the bellows, a plunger, and the expression port, and a spring is disposed within the elongated reservoir between the manual air pump and the plunger. The hemostatic powder is disposed within the elongated reservoir between the porous filter and the expression port, and the manual air pump is in a fluid communication with the expression port through the porous filter and through the hemostatic powder.

Compositions, solutions, products, devices, and methods related to EDTA, and uses thereof in treating pulmonary diseases and disorders such as cystic fibrosis are disclosed. Also disclosed are an inhalation device and an EDTA composition for dispensing via the inhalation device.