An aerosol generating system including a housing defining an airflow outlet; a liquid aerosol-forming substrate; an aerosol generator, configured to generate an aerosol from the liquid aerosol-forming substrate; a perforated plate disposed between the aerosol generator and the airflow outlet, the perforated plate defining a plurality of apertures extending through the perforated plate; and an electrode disposed between the aerosol generator and the perforated plate, wherein the perforated plate is electrically conductive, and wherein the electrode and the perforated plate are configured to generate an electrical potential.

Disclosed is a ratchet mechanism having ratchet ring and a chassis. The ratchet ring is rotatable about an axis relative to the chassis, with a general direction of rotation determined by teeth of the ratchet mechanism. The ratchet ring has a first set of teeth arranged regularly around the ratchet ring and protruding in a first axial direction from the ratchet ring and a second set of teeth arranged regularly around the ratchet ring and protruding in a second opposite axial direction from the ratchet ring. The chassis has a third set of teeth arranged regularly and protruding in the second axial direction and generally opposed to the first set of teeth, and a fourth set of teeth arranged regularly and protruding in the first axial direction and generally opposed to the second set of teeth.

Disclosed is a ratchet mechanism having ratchet ring and a chassis. The ratchet ring is rotatable about an axis relative to the chassis, with a general direction of rotation determined by teeth of the ratchet mechanism. The ratchet ring has a first set of teeth arranged regularly around the ratchet ring and protruding in a first axial direction from the ratchet ring and a second set of teeth arranged regularly around the ratchet ring and protruding in a second opposite axial direction from the ratchet ring. The chassis has a third set of teeth arranged regularly and protruding in the second axial direction and generally opposed to the first set of teeth, and a fourth set of teeth arranged regularly and protruding in the first axial direction and generally opposed to the second set of teeth.

Provided is a pharmaceutical agent for effective prophylaxis and/or treatment of a pathological condition with decreased lung compliance. The pharmaceutical agent for prophylaxis and/or treatment of a pathological condition with decreased lung compliance is characterized by having a polyamine. The polyamine includes at least one of spermine (Spm), spermidine (Spd), and putrescine (Put). The pharmaceutical agent improves lung compliance and ameliorates gas exchange dysfunction, and therefore, can ameliorate pathological conditions such as acute respiratory distress syndrome (ARDS), acute lung injury (ALI), lung diseases caused by dysfunctional endogenous pulmonary alveolar surfactant, multiple organ dysfunction syndrome (MODS), and cardiogenic pulmonary edema.

Provided is a pharmaceutical agent for effective prophylaxis and/or treatment of a pathological condition with decreased lung compliance. The pharmaceutical agent for prophylaxis and/or treatment of a pathological condition with decreased lung compliance is characterized by having a polyamine. The polyamine includes at least one of spermine (Spm), spermidine (Spd), and putrescine (Put). The pharmaceutical agent improves lung compliance and ameliorates gas exchange dysfunction, and therefore, can ameliorate pathological conditions such as acute respiratory distress syndrome (ARDS), acute lung injury (ALI), lung diseases caused by dysfunctional endogenous pulmonary alveolar surfactant, multiple organ dysfunction syndrome (MODS), and cardiogenic pulmonary edema.

An aerosol generator with an active liquid container and a nebulization chamber associated therewith, which is connected to an inlet channel for the supply of carrier gas and to an outlet channel for the discharge of carrier gas mixed with aerosol obtained from the active liquid, is intended to enable a particularly good adjustability of the droplet size of the aerosols contained in the discharged carrier gas and thus a use particularly in the context of a transnasal inhalation therapy. For this purpose, the nebulization chamber has a substantially rotationally symmetrical boundary wall, the inlet channel being positioned and oriented in the region of its point of entry into the nebulization chamber in such a way that its longitudinal axis is offset relative to the axis of symmetry of the nebulization chamber in the region of the point of entry and does not intersect the axis of symmetry.

Disclosed herein is a multi-purpose aerosol platform capable of producing and delivery of submicron and nano structured materials for pharmaceutical, biomedical and environmental applications. Depending on the application, active chemical and biological materials may be processed from liquid dispersions into droplets and/or particle formulations. The disclosed system uses moderate gas pressures to atomize liquids into submicron-size droplets that are 10-1000 times smaller in diameter than commercial and research systems. This allows much gentler and rapid droplet-to-particle conversion, applying much smaller physical and chemical stresses on the processed materials than conventional techniques like spray drying, spray coating, spray freeze drying and other technologies. For example, the disclosed system can be used for an ultra-fine nebulization and delivery of viscous therapeutic oils including oils of medical cannabis, for which conventional nebulization systems either fail or became ineffective. Such systems could help patients with acute respiratory distress syndrome (ARDS) developed in hard COVID-19 cases.

Disclosed herein is a multi-purpose aerosol platform capable of producing and delivery of submicron and nano structured materials for pharmaceutical, biomedical and environmental applications. Depending on the application, active chemical and biological materials may be processed from liquid dispersions into droplets and/or particle formulations. The disclosed system uses moderate gas pressures to atomize liquids into submicron-size droplets that are 10-1000 times smaller in diameter than commercial and research systems. This allows much gentler and rapid droplet-to-particle conversion, applying much smaller physical and chemical stresses on the processed materials than conventional techniques like spray drying, spray coating, spray freeze drying and other technologies. For example, the disclosed system can be used for an ultra-fine nebulization and delivery of viscous therapeutic oils including oils of medical cannabis, for which conventional nebulization systems either fail or became ineffective. Such systems could help patients with acute respiratory distress syndrome (ARDS) developed in hard COVID-19 cases.

A medical device including an application device with a first fluid path and a container movably attached to the application device. The container and the application device have a second fluid path therethrough, the container includes an inner chamber that is intermediate proximal and distal portions of the second fluid path, the inner chamber is fluidly isolated from the proximal portion of the second fluid path at a first position of the container, and the inner chamber is fluidly coupled to the proximal and distal portions of the second fluid path at a second position of the container. The first fluid path bypasses the container and the passage of fluid through the first fluid path is separately controllable from the passage of fluid through the second fluid path.

A system and method for dermal spraying includes a portable, hand-held dermal application device with one or more disposable cartridges that spray a dermal formulation onto the skin, the disposable cartridge having a nozzle that can be activated by placing the cartridge into the spray device.