A microfluidic device for particle analysis, such as immunophenotyping, includes a plurality of microfluidic channels for the passage of a particle-laden fluid flow, a plurality of dedicated impedance sensors for generating impedance signals relative to each microfluidic sensor. The impedance sensors are CODES Coulter sensors, each having a distinct coded sequence for generating mutually orthogonal signals. The system uses a multi-frequency excitation signal for driving the Coulter sensors, such that the Coulter sensors generate multi-frequency impedance signals. The system outputs the multi-frequency signals of the plurality of impedance sensors as a single multi-frequency multiplexed signal, which is subsequently separated into a plurality of single-frequency multiplexed signals, which are then demodulated into single-frequency component signals corresponding to each of the Coulter sensors.

A functional polymeric cutting edge structure and methods for manufacturing cutting edge structures using polymeric materials are provided. A razor blade for use in a razor cartridge or a blade box for assembly in a razor cartridge frame may be formed using the present invention.

A method employs a first polymeric material to deposit first and second pattern layers laterally shifted from each other such that laterally shifted pattern layers form between them an empty volume with a variable cross-section that varies along with the first and second pattern layers. A second polymeric material is cast in the empty volume between the first and second pattern layers to cast a complex-shaped 3D object identical in shape to the empty volume between the first and second pattern layers. Radiation is applied to cure the first and second polymeric materials. The first polymeric material is a water breakable material composition including acrylamide, methacrylamide, acrylate, acrylic acids, and acrylic acid salts, hydroxy(meth)acrylate, carboxy(meth)acrylate, acrylonitrile, carbohydrate monomers, methacrylate and polyfunctional acrylics.

A method for molding a part is disclosed wherein a molding material has a minimum viscosity. A substrate that is responsive to a magnetic or electric field is introduced to the molding material. The substrate is moved by a magnetic or electric field to form channels in the molding material. The molding material is cured during or after the channels are formed.

The present invention provides a method for the preparation of an asymmetric membranes. More particularly, the new method relates to the use of a crosslinker contacted via vapour or liquid phase with the surface layer of a cast polymer film, followed by the immersion of said film in a coagulation bath. The formation of a crosslinked skin layer and the solidification of the membrane bulk can thus be decoupled in time.

A cyanoacrylate composition with thermoplastic polyurethane, formulated as a non-flowable soft solid or semi solid mass, for example in stick form, is reported.

The present disclosure may be embodied as a method for creating a restriction pattern from a mask material having a strain (ε.sub.mask) an for mapping elastomeric membrane having a strain (ε.sub.membrane) into a target 3D shape. The method may include discretizing the target 3D shape into a plurality of radial segments, and a radial strain (ε.sub.r) is determined for each radial position (r) on each radial segment of the plurality of radial segments. A restriction pattern is determined, wherein the restriction pattern comprises a quantity of mask material for each position r to provide a composite strain (ε.sub.mask, ε.sub.silicone). In some embodiments, the method further includes depositing a first membrane layer into a mold and placing mask material into the first membrane layer according to the determined restriction pattern. The first membrane layer is cured.

Articles are provided including at least one polyurethane prepared from: (a) about 1 equivalent of at least one polyisocyanate; (b) about 0.005 to about 0.35 equivalent of at least one polycaprolactone polyol; (c) about 0.01 to about 1.0 equivalent of at least one polyol selected from the group consisting of ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,2-ethanediol, propanediol, butanediol, pentanediol, hexanediol, heptanediol, octanediol, nonanediol, decanediol, dodecane diol, octadecanediol, cyclopentanediol, 1,4-cyclohexanediol, cyclohexanedimethanol, 1,4-benzenedimethanol, xylene glycol, hydroxybenzyl alcohol, dihydroxytoluene, bis(2-hydroxyethyl) terephthalate, 1,4-bis(hydroxyethyl)piperazine, N,N′,bis(2-hydroxyethyl)oxamide and mixtures thereof; and (d) about 0.01 to about 0.5 equivalent of at least one polyol selected from the group consisting of glycerol, tetramethylolmethane, trimethylolethane, trimethylolpropane, erythritol, pentaerythritol, dipentaerythritol, tripentaerythritol, sorbitan, and mixtures thereof, each based upon the about 1 equivalent of the at least one polyisocyanate, wherein the article has a Gardner Impact strength of at least about 400 in-lb according to ASTM D-5420-04.

The present disclosure includes dental appliances and methods of making and using such appliances. One method for forming a dental appliance includes forming a liquid thermoset polymer material into a semi-solid first shape, thermoforming the semi-solid first shape of thermoset polymer material onto a dentition mold, and curing the thermoset polymer on the dentition mold with a curative trigger to complete a molecular cross-linking reaction.

The present application describes a system for curing moldable material. The system comprises an energy source, a mold, and/or other components. The mold comprises internal mold surfaces forming a mold cavity. The mold is formed from one or more materials configured to absorb electromagnetic radiation emitted by the energy source. The mold has a hot zone and a cold zone. The hot zone and the cold zone have the one or more materials thereof comprising at least one different physical characteristic so that the hot zone and the cold zone absorb the electromagnetic radiation at different rates and/or in different amounts. The hot zone absorbs more electromagnetic radiation than, and/or electromagnetic radiation faster than, the cold zone.